Correlation of NT-proBNP with metabolic liver function as assessed with 13C-methacetin breath test in patients with acute decompensated heart failure

Hendrichová, M.; Málek, Filip; Kopřivová, H; Vranová, Jana; Ošťádal, Petr; Krátká, Karolína; Sedláková, Miluše; Horák, Jiří

doi:10.1016/j.ijcard.2009.03.022

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Short-term CRT was associated with the consistent increase of ceruloplasmin level, which correlated with NT-proBNP and sST2 significantly. Correlation of ceruloplasmin with NT-proBNP has been described previously [8]. Further research in this field with long term follow-up and larger cohort is necessary.…”

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confidence: 60%

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Short term effect of CRT on biomarkers of cardiac remodelling and fibrosis: NT-proBNP, sST2, galectin-3, and a marker of oxidative stress — ceruloplasmin — A pilot study

Vondráková

Málek

Ošťádal

et al. 2012

International Journal of Cardiology

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confidence: 60%

“…Hypertensive LVH predisposes to ventricular arrhythmias and sudden death. HTN associated with LVH is an independent risk factor for CAD, stroke, peripheral artery disease, and heart failure [7,8]. LVH is an independent risk factor for sudden cardiac death (SCD) and accompanies many causes of SCD [9].…”

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confidence: 99%

Short term effect of CRT on biomarkers of cardiac remodelling and fibrosis: NT-proBNP, sST2, galectin-3, and a marker of oxidative stress — ceruloplasmin — A pilot study

Vondráková

Málek

Ošťádal

et al. 2012

International Journal of Cardiology

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“…In the patients with acute decompensated heart failure, ceruloplasmin correlated with NT-proBNP levels in a small study evaluated association of heart failure severity with the level of metabolic liver function [16].…”

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confidence: 99%

Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure Clinic

Málek¹,

Vondráková²,

Komendová³

et al. 2015

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Background: Ceruloplasmin is an acute phase protein with plasma copper binding properties, and is a potent extracellular antioxidative enzyme. Inflammation and oxidative stress might explain the role of ceruloplasmin in the pathophysiology of heart failure. Study objective: The objective is to assess the correlation of ceruloplasmin levels with biomarkers of cardiac remodelling and myofibrosis in patients with acute decompensated heart failure. Patients and methods: Blood samples were taken and serum levels of soluble ST2, galectin-3, NT-proBNP and ceruloplasmin were analysed in 31 consecutive patients with systolic HF referred to tertiary care nurse lead heart failure clinic with acute decompensated CHF requiring i.v. diuretics. The mean patients' age was 68 years, mean left ventricular ejection fraction (LV EF) was 29%, 66% patients had ischemic aetilogy of CHF and 33% had atrial fibrillation. Results: The mean ceruloplasmin level was 0.243 g/l, mean galectin-3 level was 1.26 ng/ml, mean sST2 level was 38.15 ng/ml, and mean NT-proBNP was 1927 pg/ml. The ceruloplasmin level correlated with NT-proBNP (r = 0.58, p < 0.05) and with sST2 (r = 0.77, p < 0.001), sST2 levels correlated significantly with NT-proBNP (r = 0.66, p < 0.01). The ceruloplasmin level did not correlate with galectin-3 concentration. Conclusion: The ceruloplasmin level correlates with the biomarkers of cardiac remodelling (NT-proBNP, sST2), but not with the biomarker of myofibrosis (galectin-3). This finding supports the hypothesis of inflammatory re-* Corresponding author. F. Málek et al. 972 sponse in acute decompensated heart failure.

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“…In the study by Hammadah et al, there was a weak but positive relationship between HF and serum CP levels (30) . In addition, NT-proBNP may be correlated with serum CP levels in acute decompensated HF (36) .The existence of a positive relationship between serum CP levels and the functional class of HF has also been observed (29) .…”

Section: Heart Failurementioning

confidence: 95%

How to Change Ceruloplasmin Levels in Heart Disease?

Sezen¹,

Sezen²

2018

Kosuyolu Heart Journal

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Ceruloplasmin (CP) is a blue serum protein found in human serum; it carries approximately 95% of the total circulating copper (Cu) in healthy individuals. The relationship of CP with OS, inflammation, and DNA damage is known. Oxidative stress (OS), inflammation, and DNA damage are the main causes underlying atherosclerotic heart disease. Several studies have indicated a close association between high serum CP and several types of heart disease. However, the CP levels are still unknown in many heart diseases. To gather the studies of CP in heart disease and to prepare the ground for new studies for researchers, we designed this review.

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Correlation of NT-proBNP with metabolic liver function as assessed with 13C-methacetin breath test in patients with acute decompensated heart failure

Cited by 9 publications

References 6 publications

Short term effect of CRT on biomarkers of cardiac remodelling and fibrosis: NT-proBNP, sST2, galectin-3, and a marker of oxidative stress — ceruloplasmin — A pilot study

Short term effect of CRT on biomarkers of cardiac remodelling and fibrosis: NT-proBNP, sST2, galectin-3, and a marker of oxidative stress — ceruloplasmin — A pilot study

Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure Clinic

How to Change Ceruloplasmin Levels in Heart Disease?

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