Correlation of nucleated red blood cells with severity of birth asphyxia and its immediate outcome in term newborns

Meena, Pradeep; Gunawat, Maheshwar; Suman, Rameshwar Lal

doi:10.18203/2349-3291.ijcp20161430

Cited by 4 publications

(4 citation statements)

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“…14 In this study 112 newborns were studied, to assess the association of NRBC with perinatal hypoxia and we found average of NRBCs was seen significantly high in cases 16.62+17.10 as compared to control group as 1.69+2.42 (p=0.0001) along with the average of neonatal NRBs was significantly associated to severity of perinatal hypoxia (p-0.0001). Consistently Meena P et al 15 reported that the average of NRCs count was significantly higher 17.82±19.55 in the with birth asphyxia, in contrast to controls 1.42±3.26, and furthermore they found a strong negative correlation of NRBCs with the severity of birth asphyxia. Kumar A et al 16 also found almost similar findings as the average nRBCs was markedly higher 20.97±8.17 in the cases of Perinatal asphyxia, compared to the controls (5.57±1.98) (p-0.0001) On the other hand, Jyoti Biswas et al 17 reported that the average nRBCs was significantly higher (54.06+22.42) in case group as compared to controls (10.32+5.86) (p-0.001).…”

Section: Discussionsupporting

confidence: 70%

“…Consistently Kumar A et al 16 reported that there was no significant difference in the cases and controls according to average age of the mothers, mean age of gestation, average weight of birth, and gender of the newborns. On the other hand, Meena P et al 15…”

Section: Discussionmentioning

confidence: 99%

“…All the babies admitted after 24 hours of delivery, those having any other risk factor (Cyanotic heart disease, intrauterine growth restriction, Hemolytic disease of new born, Post term babies) or patients having any dysmorphism assessed on history and medical records were excluded. The severity of birth asphyxia was categorized as mild (1-10), moderate (11)(12)(13)(14), and severe (15) according to the Thompson scoring of hypoxic ischemic encephalopathy. 12 A detailed history was taken, and important aspects were noted, like the mode of delivery, place of delivery, history of crying at the time of delivery, history of prolong or obstructed labor, history of antenatal steroids, gestational age, history of leaking, vaginal discharge, and fever in the perinatal period.…”

Section: Meth Odo Log Ymentioning

confidence: 99%

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Relationship of Nucleated Red Blood Cells with Severity of Perinatal Asphyxia and its Short-Term Outcome

Iqbal

Razzaq

Malik

et al. 2022

Ann Pak Inst Med Sci

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Objective: To compare the nucleated red blood cell (NRBC) counts of healthy and asphyxiated newborns as a key clinical indicator of the severity of birth asphyxia and short-term outcome. Methodology: This case control study was conducted at the paediatric department of neonatology of Recep Tiyyap Erdogan Hospital Muzaffargarh from June 2020 to November 2020. Study A total of 112 term newborns, including 56 cases (with birth asphyxia) and 56 controls (normal babies) aged <24 hours, were included. After obtaining informed consent, blood samples were taken immediately after birth for the measurement of the NRBC count. All the enrolled cases were admitted to the NICU as per indication and observed for the severity of birth asphyxia. The relationship between the cord blood NRBC count and the severity of birth asphyxia was assessed. All the information was recorded using a self-structured study proforma, and SPSS version 26 was used for the purpose of data analysis. Results: The overall average age of the neonates was 6.18+2.66 hours. Mean age, birth weight, and gestational age were statistically insignificant in accordance to cases and controls. Males were in the majority (75.0%), and females were 25.0% of the case group. The mean NRBCs in the cases were 16.62 + 17.10, which was significantly higher than the controls at 1.69 + 2.42 (p- 0.0001). The neonatal NRBs average was statistically insignificant according to gender in both cases and controls, while it was significantly associated with the severity of perinatal hypoxia (p 0.0001). The average NRBC count was also significantly higher in cases of cardiomegaly, those having ventilation needs and respiratory distress. Conclusion: The mean NRBC was observed to be significantly higher in cases compared to controls. The NRBC was considered to be a non-invasive, simple prognostic marker for neonatal asphyxia, may indicate substantial severity of perinatal hypoxia and its related complications.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Meth Odo Log Ymentioning

confidence: 99%

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Relationship of Nucleated Red Blood Cells with Severity of Perinatal Asphyxia and its Short-Term Outcome

Iqbal

Razzaq

Malik

et al. 2022

Ann Pak Inst Med Sci

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“…Meena P et al [15], in their study compared mean nucleated RBC count in neonates with and without birth asphyxia. A statistically significant negative correlation of nRBC count was found with severity of birth asphyxia.…”

Section: Discussionmentioning

confidence: 99%

Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Sandhya

et al. 2018

Int J Pediatr Res

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Introduction: This study was done to estimate the nucleated red blood cell count (NRBCs) in normal and asphyxiated babies and find their correlation with severity of birth asphyxia. Materials and Methods: About 50 normal newborns as control and 50 newborns with perinatal asphyxia as cases were considered. At birth 2 mL of venous blood was collected in both cases and control groups. nRBC count per 100 white blood cells (WBC) was done at admission. Clinical assessments in terms of neurologic status at birth, 24 hours after birth and every day thereafter till discharge/death was done. Cord blood nRBC/100 WBC was correlated with stages of HIE during hospital stay. Neonates were monitored for adverse outcome such as tone abnormalities, feeding difficulty, refractory seizures and death. Controls were followed up in the same manner. Results: Among 50 cases, 24 had no hypoxic ischaemic encephalopathy (HIE),17 had stage 1 HIE, 6 had stage 2 and 3 newborns had stage 3 HIE. The mean APGAR score in cases was 5.34 ± 1.19 whereas for the control group it was 8.12 ± 0.77 with p value of 0.001 which is statistically significant. The mean nRBC in newborns with APGAR score of 3, 4,5, 6 were 35.5, 19.9, 20.6 and 12 respectively. The low APGAR scores showed high nRBCs. Mean nRBCs for HIE stage 1, 2, 3 was 19.1, 31.0, and 54.3 respectively. High nRBC count correlated with increasing severity of birth asphyxia. Conclusion: nRBC count is an easy, simple and a reliable test to assess the severity of birth asphyxia in resource poor settings.

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Comparative Study to Correlate Hematological Parameters with the Severity of Birth Asphyxia

Mamatha,

Meena,

Sulaniya

et al. 2023

CHRISMED Journal of Health and Research

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Introduction: Birth asphyxia can alter biophysical characteristics of erythrocytes, leukocytes and platelets. Nucleated red blood cell (NRBC) in the umbilical venous blood of neonates has been reported as a possible marker of perinatal asphyxia. NRBCs, platelet count, total leukocyte count, hemoglobin, and hematocrit were taken as hematological parameters. The purpose of this study was to evaluate the various hematological changes following birth asphyxia and their correlation with the severity of birth asphyxia and its outcome. Materials and Methods: It was hospital-based comparative observation study conducted in neonatal units of a tertiary hospital in the northern part of India from May 2019 to May 2020. All term appropriate for gestational age newborns with birth asphyxia were taken as cases and healthy newborns as controls. The sample size of 80 participants in each group was calculated. 2 ml cord blood sample was taken for parameters used in the study. P < 0.05 was taken as statistically significant. Results: There was no statistically significant difference in relation to sex distribution, birth weight, parity of mothers, and mode of delivery between cases and controls. NRBC and total leukocyte count were statistically positively correlated with the severity of hypoxic-ischemic encephalopathy (HIE), whereas hemoglobin, hematocrit, and platelet counts were not statistically significant. Area under the Receiver operating characteristic (ROC) curve of NRBC was 0.812, and the NRBC count cutoff of >20 has a sensitivity of 83% and specificity of 72%. Forty-six percent of total cases with NRBC 20 or more died. Conclusions: NRBC has a significant positive correlation with the severity of HIE and a negative with the Apgar score. NRBCs value more than or equal to 20 can be used as a prognostic marker for assessing the severity and outcome of birth asphyxia.

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Correlation of nucleated red blood cells with severity of birth asphyxia and its immediate outcome in term newborns

Cited by 4 publications

References 8 publications

Relationship of Nucleated Red Blood Cells with Severity of Perinatal Asphyxia and its Short-Term Outcome

Relationship of Nucleated Red Blood Cells with Severity of Perinatal Asphyxia and its Short-Term Outcome

Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Comparative Study to Correlate Hematological Parameters with the Severity of Birth Asphyxia

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