Correlation of Ocular Pulse Amplitude, Choroidal Thickness, and Internal Carotid Artery Doppler Ultrasound Findings in Normal Eyes

Demirok, Gülizar; Topalak, Yasemin; Başaran, Mustafa; Ataç, Gökçe Kaan; Ozturk, S.; Şengün, Ahmet

doi:10.3109/08820538.2016.1141223

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…OPA recorded by dynamic contour tonometry was lower in eyes with lower IOP, longer axial length or thinner SFCT, but not correlated with CCT, corneal curvature or anterior chamber depth in healthy participants. 39 , 40 In contrast, we found that ACV, but not axial length or SFCT, was associated with several OPA parameters of CLS. The discrepancy may stem from the differences in characteristics of the study participants and the position and mechanism for detecting ocular pulse between dynamic contour tonometry and CLS.…”

Section: Discussioncontrasting

confidence: 68%

Association of Ambulatory Blood Pressure and Other Factors With Intraocular Pressure–Related 24-Hour Contact Lens Sensor Profile in Untreated Glaucoma

Nakazawa

Higashide

Tsuchiya

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To investigate the association of diurnal blood pressure (BP) and other factors with the intraocular pressure (IOP)–related 24-hour contact lens sensor (CLS) profile of patients with untreated glaucoma. Methods The prospective study included 82 patients with untreated normal-tension glaucoma. CLS measurements and ambulatory BP monitoring were performed simultaneously for 24 hours. The association between the mean arterial pressure (MAP) and CLS profile was examined for the daytime and nocturnal periods using linear regression analysis. The associations between other factors and the CLS profile were also examined. Results Multivariate analysis of data from 63 eligible patients showed that higher average MAPs were significantly associated with larger average nocturnal CLS values (β coefficient = 0.273; P = 0.023); a larger increase in the last CLS value (β coefficient = 0.366; P = 0.003); larger standard deviations (SDs) of CLS values for the daytime, nocturnal, and 24-hour periods (β coefficient = 0.407, 0.293, and 0.375; P < 0.001, P = 0.032 and 0.002, respectively); and higher average ocular pulse frequencies for the daytime, nocturnal, and 24-hour periods (β coefficient = 0.268, 0.380, and 0.403; P = 0.029, 0.002, and 0.001, respectively). Thicker subfoveal choroids and shorter axial length were significantly associated with larger SDs and larger average CLS values, respectively. Smaller anterior chamber volume and lower corneal hysteresis were associated with larger SDs or larger average ocular pulse amplitude. Conclusions Ambulatory BP and several ocular parameters were significantly associated with various parameters of the 24-hour CLS profile. Translational Relevance Ambulatory BP and ocular parameters may be modifiers of the 24-hour IOP-related profile of CLS.

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Section: Discussioncontrasting

confidence: 68%

Association of Ambulatory Blood Pressure and Other Factors With Intraocular Pressure–Related 24-Hour Contact Lens Sensor Profile in Untreated Glaucoma

Nakazawa

Higashide

Tsuchiya

et al. 2022

Trans. Vis. Sci. Tech.

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“…Indeed, a study revealed a positive correlation between the ocular pulse amplitude and SFCT in patients younger than 50 years. 23 Besides, vasodilator treatments such as sildenafil induce an increase in choroidal perfusion concomitantly with an increase in choroidal thickness. 24,25 These results corroborate the hypothesis that treatments improving ophthalmic vascularization may have an increasing effect on choroidal thickness.…”

Section: Discussionmentioning

confidence: 99%

“…18,[20][21][22] Although the link between choroidal thickness and vascular supply has been so far poorly investigated, several studies suggest that eye vascularization may have an impact on choroidal thickness. [23][24][25] The aim of this pilot study was to investigate the impact of ICA stenosis on subfoveal choroidal thickness (SFCT) and explore its variation after surgical treatment by CEA.…”

Section: Introductionmentioning

confidence: 99%

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Lareyre

Nguyen²,

Raffort

et al. 2017

Angiology

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The influence of both severe chronic carotid stenosis and carotid endarterectomy (CEA) on ocular tissue has been poorly evaluated. The goal of this study was to measure subfoveal choroidal thickness (SFCT), before and after CEA, in patients with severe carotid stenosis. Consecutive patients (n = 36) with severe carotid stenosis were prospectively included. Patients (n = 19) were followed up at 1 and 3 months after CEA. The SFCT was measured bilaterally using enhanced depth imaging optical coherence tomography (EDI-OCT). Preoperatively, the median SFCT of the ipsilateral eye did not differ significantly from the contralateral eye (223 vs 236 µm; P = .75). In the ipsilateral eye, the mean SFCT was significantly higher at 1 month postsurgery and the effect was maintained at 3 months (226.3 ± 17.1 at 3 months vs 210.8 ± 16.5 µm at baseline; P < .001). For the contralateral eye, the increase in SFCT reached statistical significance at 3 months (220.1 ± 11.3 at 3 months vs 214.8 ± 11.5 µm at baseline; P = .04). The mean SFCT significantly increased bilaterally after CEA, with a more noticeable effect in the ipsilateral eye. Further studies are required to determine whether EDI-OCT could be useful as a potential marker of ophthalmologic outcomes.

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“…In healthy subjects and patients with glaucoma, other studies have found that CT was independently associated with ocular perfusion pressure after adjusting for refractory errors, suggesting that CT may indirectly reflect ocular perfusion status. 20 , 21 Ocular pulse amplitude (OPA), which provides information on intraocular blood flow, is considered to be an indicator of choroidal perfusion, and Demirok et al 22 reported that OPA was strongly correlated with CT in healthy subjects ( r = 0.481, P = 0.001). Novais et al 23 used color Doppler flowmetry to measure retrobulbar blood flow, and they found a negative correlation between CT and retrobulbar arterial resistance index; these results imply that decreased choroidal blood flow could explain CT thinning in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Macular Choroidal Thickness and the Risk of Referable Diabetic Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study

Wang

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to evaluate the associations between choroidal thickness (CT) and the 2-year incidence of referable diabetic retinopathy (RDR). Methods This was a prospective cohort study. Patients with type 2 diabetes in Guangzhou, China, aged 30 to 80 years underwent comprehensive examinations, including standard 7-field fundus photography. Macular CT was measured using a commercial swept-source optical coherence tomography (SS-OCT) device (DRI OCT Triton; Topcon, Tokyo, Japan). The relative risk (RR) with 95% confidence intervals (CIs) was used to quantify the association between CT and new-onset RDR. The prognostic value of CT was assessed using the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results A total of 1345 patients with diabetes were included in the study, and 120 (8.92%) of them had newly developed RDR at the 2-year follow-up. After adjusting for other factors, the increased RDR risk was associated with greater HbA1c (RR = 1.35, 95% CI = 1.17–1.55, P < 0.001), higher systolic blood pressure (SBP; RR = 1.02, 95% CI = 1.01–1.03, P = 0.005), lower triglyceride (TG) level (RR = 0.81, 95% CI = 0.69–0.96, P = 0.015), presence of diabetic retinopathy (DR; RR = 8.16, 95% CI = 4.47–14.89, P < 0.001), and thinner average CT (RR = 0.903, 95% CI = 0.871–0.935, P < 0.001). The addition of average CT improved NRI (0.464 ± 0.096, P < 0.001) and IDI (0.0321 ± 0.0068, P < 0.001) for risk of RDR, and it also improved the AUC from 0.708 (95% CI = 0.659–0.757) to 0.761 (95% CI = 0.719–0.804). Conclusions CT thinning measured by SS-OCT is an early imaging biomarker for the development of RDR, suggesting that alterations in CT play an essential role in DR occurrence.

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Correlation of Ocular Pulse Amplitude, Choroidal Thickness, and Internal Carotid Artery Doppler Ultrasound Findings in Normal Eyes

Abstract: A fair correlation was found between the OPA and subfoveal CT in healthy subjects under the age of 50.

Cited by 8 publications

References 17 publications

Association of Ambulatory Blood Pressure and Other Factors With Intraocular Pressure–Related 24-Hour Contact Lens Sensor Profile in Untreated Glaucoma

Association of Ambulatory Blood Pressure and Other Factors With Intraocular Pressure–Related 24-Hour Contact Lens Sensor Profile in Untreated Glaucoma

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Macular Choroidal Thickness and the Risk of Referable Diabetic Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study

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