Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients

Kotur‐Stevuljević, Jelena; Memon, Lidija; Stefanović, Aleksandra; Spasić, Slavica; Spasojević‐Kalimanovska, Vesna; Bogavac-Stanojević, Nataša; Kalimanovska-Oštrić, Dimitra; Jelić‐Ivanović, Zorana; Z̆unić, Gordana

doi:10.1016/j.clinbiochem.2006.09.007

Cited by 128 publications

(83 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The levels of MDA are significantly higher in patients as compared to those in normal healthy individuals. This increase in MDA despite neutralization of free radicals by GSH, depicts the persisting oxidative stress and depletion of protective mechanisms, which lead to persistent damage by free radicals [31].…”

Section: Methodsmentioning

confidence: 99%

Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Uppal

2014

JCDR

View full text Add to dashboard Cite

Introduction: There is now a consensus that atherosclerosis represents a state of heightened oxidative stress which is characterized by lipid and protein oxidation in the vascular wall. Inspite of many efforts which were made to explain the role of oxidative stress in progression of CAD (Coronary Artery Disease), its predictive role is still not clear. In order to fill these lacunae and to establish the utility of antioxidant vitamins in delaying the progression of CAD from stable angina (SA) towards myocardial Infarction (MI), the present study was conducted.

show abstract

Section: Methodsmentioning

confidence: 99%

Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Uppal

2014

JCDR

View full text Add to dashboard Cite

show abstract

“…Therefore, EC-SOD do not appear a useful marker for the diagnosis of CAD or to stratify the patients population [30] (Table 1), but it may represent a good therapeutic target against ROS in CAD. In another study, Kotur-Stevuljevic et al [31] found that the enzymatic activity of erythrocyte SOD in patients with CAD was significantly decreased comparing to healthy volunteers. A significant difference was also evident among patients with stenosis less than 50% compared to those with stenosis higher than 50%.…”

Section: Association Between Antioxidant Enzyme and Vascular Diseasementioning

confidence: 99%

Enzymatic antioxidant system in vascular inflammation and coronary artery disease

Lubrano

Balzan

2015

WJEM

123

View full text Add to dashboard Cite

In biological systems there is a balance between the production and neutralization of reactive oxygen species (ROS). This balance is maintained by the presence of natural antioxidants and antioxidant enzymes such as superoxide dismutase (SOD), catalase and glutathione peroxidase. The enhancement of lipid peroxidation or the decrease of antioxidant protection present in metabolic diseases or bad lifestyle can induce endothelial dysfunction and atherosclerosis. Clinical studies have shown that oxidative stress can increase ROS reducing the formation of antioxidant defences, especially in subjects with coronary artery disease (CAD). Some observation indicated that in the early stages of the disease there is a homeostatic upregulation of the antioxidant enzyme system in response to increased free radicals to prevent vascular damage. As soon as free radicals get to chronically elevated levels, this compensation ceases. Therefore, SOD and the other enzymes may represent a good therapeutic target against ROS, but they are not useful markers for the diagnosis of CAD. In conclusion antioxidant enzymes are reduced in presence of metabolic disease and CAD. However the existence of genes that promote their enzymatic activity could contribute to create new drugs for the treatment of damage caused by metabolic diseases or lifestyle that increases the plasma ROS levels. Core tip: This review shows that antioxidant enzymes are very important factors for the prevention and treatment of atherosclerotic disease, but more studies are required to understand whether they can be used as markers for diagnosis of coronary artery disease. The presence of polymorphic genes that increases the activity and expression of these enzymes can be considered important for the development of new therapeutic strategies. In our opinion further efforts should be directed especially on this last point, in MINIREVIEWS

show abstract

“…IMA may show a sensitive biochemical marker, especially for the diagnosis of myocardial ischemia (Sinha et al, 2004). Several reports proved that ischemia induces a cascade of proinflammatory reactions that lead to the production of ROS (Kotur-Stevuljevic et al, 2007;Vassalle et al, 2008). IMA is indicated a marker of ischemia and oxidative stress originating as a consequence of tissue hypoxia (Can et al, 2006;Senes et al, 2007;Lippi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

show abstract

Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients

Cited by 128 publications

References 32 publications

Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Enzymatic antioxidant system in vascular inflammation and coronary artery disease

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Contact Info

Product

Resources

About