Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Vasilenko, A M; Yanovskii, O. G.; Koptelov, O. V.; Metaksa, E. E.; Захарова, Л. А.

doi:10.1007/bf02445902

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…Our fi ndings indicate that changes in these parameters are specifi c and depend on the period of study and type of immune reactions during antigenic stimulation. These results complement published data on the relationship between nociception and immune status of animals [1,4]. However, the contribution of individual cytokines in the regulation of nociceptive sensitivity in mammals during antigenic stimulation remains unknown.…”

supporting

confidence: 79%

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Correlation Dependencies between Nociceptive Sensitivity and Cytokine Level in Biological Fluids of Rats after Administration of Lipopolysaccharide

Abramova

Перцов

2014

Bull Exp Biol Med

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Correlation dependencies between nociceptive sensitivity and cytokine level in biological tissues of rats were studied on days 1 and 7 after antigenic stimulation due to intraperitoneal injection of LPS (30 μg/kg). No correlations were found between the nociceptive thresholds and cytokine contents in the dorsal hippocampus and anterior cingulate cortex of animals. Inverse correlations between the tail-flick latency in response to nociceptive stimulation and concentrations of an anti-inflammatory cytokine IL-10 and pro-inflammatory cytokine TNF-α in the peripheral blood of rats were revealed on day 7 after LPS injection. These animals were characterized by the following inverse correlations between the blood level of proinflammatory cytokines and baseline parameters of nociceptive sensitivity: IL-4 and latency of the tail-flick response; and IL-10 and vocalization threshold. The appearance of significant correlations between immune and nociceptive parameters in rats was shown to coincide with pronounced changes in the perceptual and emotional components of nociception in animals during antigenic stimulation. The formation of close interrelations between nociceptive sensitivity and immune processes in this period probably contributes to the systemic response to antigenic stimulation. Our results complement previous data on the relationship between individual immune reactivity and type of nociceptive reactions in mammals.

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supporting

confidence: 79%

“…Our fi ndings complement previous data on the relationship between individual immune reactivity and type of nociceptive reactions in animals. For example, correlations were revealed between nociceptive sensitivity and immune status of mammals [4].…”

Section: Resultsmentioning

confidence: 98%

Correlation Dependencies between Nociceptive Sensitivity and Cytokine Level in Biological Fluids of Rats after Administration of Lipopolysaccharide

Abramova

Перцов

2014

Bull Exp Biol Med

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“…According to the opinion of a few experimenters [26], the first behavioral defensive phenomena in the hot-plate test (taking off and licking of the limbs) constitute the motor components of the response to nociceptive sensations, and these effects characterize the PT. The subsequent manifestations (jumpings, vocalization, etc.)…”

Section: Effects Of Ehf Emr On Behavioral Phenomena In Rats With Expementioning

confidence: 99%

Antinociceptive effects of low-intensity extrahigh-frequency electromagnetic radiation

Chuyan

Dzheldubayeva

2006

Neurophysiology

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We studied the effect of low-intensity extrahigh-frequency (EHF) electromagnetic radiation (EMR) on changes of behavior phenomena in rats observed under conditions of experimentally induced tonic somatic, visceral, and acute thermal pain. Preliminary irradiation of the animals with EHF EMR was found to exert clear antinociceptive effects. Decreases in the intensity of pain reactions were observed under conditions of both single and repeated irradiation sessions.

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“…Увеличение с возрастом распространенности онкологических заболеваний, а также патологий, сопровождающихся болевым синдромом, определяет актуальность изучения влияния хронической боли на опухолевый процесс и состояние организма при одновременном выявлении факторов, модулирующих такое влияние. Известно, что развитие болевого синдрома имеет многоуровневый характер и связано с изменениями в центральных и периферических структурах нейроэндокринной и иммунной систем [1][2][3]. При этом результат болевого воздействия, как и воздействия любой другой модальности, должен зависеть от интенсивности действующего фактора и состояния нейроэндокринной регуляции [4,5].…”

Section: Introductionunclassified

Influence of Unilateral Sciatic Nerve Ligation on the Tumor-Bearing Rats With the Features of Systemic Regulation

Zhukova¹,

Шихлярова²,

Goncharova³

et al. 2021

Sib. onkol. ž.

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The issue of factors that modify the tumor process stays relevant. The effect of unilateral sciatic nerve ligation on the growth of Guerin's transplantable carcinoma and the lifespan of white outbred rats of the same age, which differed in adaptation status and aging rates, was studied.Material and Methods. The motor activity (open field test), the character and tension of the general nonspecific adaptional reactions of the body (AR) according to Garkavi–Kvakina–Ukolova, the dynamics of tumor sizes and the lifespan of rats after Guerin’s carcinoma transplantation were evaluated.Results. The effect of unilateral sciatic nerve ligation differed from the unidirectional negative effects known in tumor-bearing animals after bilateral ligation of the sciatic nerve. In groups with unilateral ligation of the sciatic nerve and a false operation, more than 40 % of animals showed an increase in lifespan compared with the maximum lifespan in the control group. At the same time, in the most cases, the tumor growth rate was similar to the control indicators or exceeded them (more 25 % of cases). A temporary inhibition of tumor growth was observed only in individual animals. There was no direct relationship between tumor growth or lifespan and the degree of decrease in the motor activity of animals 4 weeks after nerve ligation. A correlation between the changes in the ARs and lifespans of animals and, to a lesser extent, the dynamics of tumor growth was observed. The distinct negative effect of increased aging rate, measured by animal weight, on tumor development and lifespan in studied rats was shown, but not in the cases of sciatic nerve ligation. Unilateral sciatic nerve ligation had a multidirectional effect on tumor growth and lifespan in rats with different rates of aging, depending, probably, on the individual pain sensitivity and the individual features of systemic regulation of tumor-bearing animals.Conclusion. The results reflect the complex relationship between processes associated with chronic pain, oncogenesis, aging and features of neuroendocrine and immune regulation of experimental animals. The question of the reasons for the preservation of viability in animals that underwent surgery and ligation of the sciatic nerve, when the tumors reach large sizes, exceeding this indicator in the control group, needs to be clarified.

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Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation

Cited by 4 publications

References 7 publications

Correlation Dependencies between Nociceptive Sensitivity and Cytokine Level in Biological Fluids of Rats after Administration of Lipopolysaccharide

Correlation Dependencies between Nociceptive Sensitivity and Cytokine Level in Biological Fluids of Rats after Administration of Lipopolysaccharide

Antinociceptive effects of low-intensity extrahigh-frequency electromagnetic radiation

Influence of Unilateral Sciatic Nerve Ligation on the Tumor-Bearing Rats With the Features of Systemic Regulation

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