Correlation of Plasma 4,5-Bis (p-methoxyphenyl)-2-phenylpyrrole-3- acetonitrile Levels with Biological Activity

Synthesis of 2,3,4,5-tetrasubstituted pyrroles and 1,4-dihydro-tetraarylpyrazines using acidic alumina as a heterogeneous catalyst

“…1). Polyfunctionalized pyrroles have attracted particular attention in drug discovery due to their various pharmacological properties [4] such as antibacterials [6], antitumorals, as well as antifungal [7], anti-inflammatory [8], antioxidant [9], and central nervous system agents [4].…”

Solvent‐Free Synthesis of Pyrroles: An Overview

“…[15,16] Many of the pyrrole moieties are attributed with their active drug likeness. They are owing to their anti-inflammator, [17] anti-oxidant, [18] antitumor [19] hypolipidemic, [20] immunosuppressant, [21] anti-viral, anti-bacterial [22] and insecticidal [23] activities and thus act as a versatile component of material chemistry [24,25] as well as in organic synthesis. In a synthetic point of view of pyrroles, various methods have established such as the classical Hantzsch procedure, [26] Knorr synthesis, [27] Paal-Knorr synthesis, [28] Piloty-Robinson synthesis, [29] Feist synthesis, [30] etc.…”

Recent advances in the synthesis of pyrroles via multicomponent reactions using arylglyoxals

“…[8][9][10][11][12][13][14] The important pharmaceutical, biological and materials science applications of pyrrole, and its significance as an intermediate in the synthesis of natural products, have led pyrroles to become an important class of heterocyclic compounds in organic chemistry. [14][15][16][17][18][19][20][21] Therefore, due to the manifold pharmaceutical and biological properties of pyrrole derivatives, such as antibacterial, [22][23][24][25][26] anticancer [27][28][29][30][31][32][33] (for the treatment of several types of tumor), antifungal, [34][35][36][37] antiinflammatory, [38][39][40] antiviral, 41,42 antimalarial, 43 antiparasitic, 44 anticholestaemic (Atorvastatin is a drug widely used as a cholesterol-lowering agent), 45 antibiotic, 46 anti-HIV, [47][48][49] antioxidant, [50][51]…”