Correlation of plasma interleukin-18 concentration and severity of renal involvement and disease activity in systemic lupus erythematosus

Jafari-Nakhjavani, Mohammad Reza; Abediazar, Sima; Nejati, Babak

doi:10.15171/jnp.2016.05

Cited by 28 publications

(24 citation statements)

References 25 publications

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“…Finally, we demonstrated that NHBE cells exposed to both types of DEPs released IL-18, a key pro-inflammatory cytokine that works as a pleiotropic immune regulator by IFN-γ production, in the culture medium. Of note, IL-18 has been reported to play a potential pathological role in RA and SLE 60 – 64 .…”

Section: Discussionmentioning

confidence: 99%

Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells

et al. 2018

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A variety of environmental agents has been found to influence the development of autoimmune diseases; in particular, the studies investigating the potential association of systemic autoimmune rheumatic diseases with environmental micro and nano-particulate matter are very few and contradictory. In this study, the role of diesel exhaust particles (DEPs), one of the most important components of environment particulate matter, emitted from Euro 4 and Euro 5 engines in altering the Normal Human Bronchial Epithelial (NHBE) cell biological activity was evaluated. NHBE cells were exposed in vitro to Euro 4 and Euro 5 particle carbon core, sampled upstream of the typical emission after-treatment systems (diesel oxidation catalyst and diesel particulate filter), whose surfaces have been washed from well-assessed harmful species, as polycyclic aromatic hydrocarbons (PAHs) to: (1) investigate their specific capacity to affect cell viability (flow cytometry); (2) stimulate the production of the pro-inflammatory cytokine IL-18 (Enzyme-Linked ImmunoSorbent Assay -ELISA-); (3) verify their specific ability to induce autophagy and elicit protein citrullination and peptidyl arginine deiminase (PAD) activity (confocal laser scanning microscopy, immunoprecipitation, Sodium Dodecyl Sulphate-PolyAcrylamide Gel Electrophoresis -SDS-PAGE- and Western blot, ELISA). In this study we demonstrated, for the first time, that both Euro 4 and Euro 5 carbon particles, deprived of PAHs possibly adsorbed on the soot surface, were able to: (1) significantly affect cell viability, inducing autophagy, apoptosis and necrosis; (2) stimulate the release of the pro-inflammatory cytokine IL-18; (3) elicit protein citrullination and PAD activity in NHBE cells. In particular, Euro 5 DEPs seem to have a more marked effect with respect to Euro 4 DEPs.

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Section: Discussionmentioning

confidence: 99%

Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells

et al. 2018

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“…One study has shown that PBMC from SSc patients with renal involvement produced less IL‐18 in response to stimulation with phytohaemagglutinin (PHA) compared to those without renal involvement . However, studies in other autoimmune conditions, such as SLE, strongly suggest a role for IL‐18 in renal disease . Future research examining the potential role of IL‐18 in renal, cardiac and pulmonary SSc manifestations on a larger prospective cohort would be worthwhile.…”

Section: Discussionmentioning

confidence: 99%

“…4 However, studies in other autoimmune conditions, such as SLE, strongly suggest a role for IL-18 in renal disease. [26][27][28] Future research examining the potential role of IL-18 in renal, cardiac and pulmonary SSc manifestations on a larger prospective cohort would be worthwhile. Likewise, further studies investigating the molecular and cellular mechanisms by which IL-18 might regulate fibroblasts and fibrosis would be of considerable interest.…”

Section: Discussionmentioning

confidence: 99%

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis

et al. 2019

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Objectives Systemic sclerosis ( SS c) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SS c remains poorly understood, although studies have indicated a role for the innate immune response. Methods Here, we measured serum interleukin ( IL )‐1α, IL ‐1β and IL ‐18 levels in 105 SS c patients and 47 healthy controls ( HC ) and analysed them with respect to multiple clinical parameters. Results Serum IL ‐18 concentrations were significantly higher in SS c patients than in HC , while no significant differences in concentrations of IL ‐1α and IL ‐1β were observed between SS c and HC . In both SS c and HC serum, IL ‐1α and IL ‐1β were positively correlated, while in SS c, both cytokines negatively correlated with IL ‐18. Serum IL ‐18 was significantly negatively correlated with both carbon monoxide transfer coefficient ( KCO ) and diffusing capacity of the lungs for carbon monoxide ( DLCO ). Serum IL ‐1β was positively correlated with the modified Rodnan skin score ( mRSS ), particularly in patients with limited subtype. DLCO , KCO and tricuspid regurgitation ( TR ) velocity were significantly higher in patients with high serum IL ‐1β. Serum IL ‐1α was significantly lower in SS c patients with low KCO and positively correlated with KCO . SS c patients with high serum IL ‐1α concentrations were more likely to have digital ulcers. Conclusions Our data suggest that these IL ‐1 family cytokines may have different roles in the pathogenesis of SS c fibrotic complications.

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“…IL-18 is a potential pro-inflammatory cytokine. Although the involvement of IL-18 has been implicated in various diseases, especially autoimmune diseases, such as allergy and systemic lupus erythematosus 7 , 21 , only a few studies have demonstrated IL-18 regulation is involved in inflammatory myopathy 22 . We show that HIMF induces IL-18 expression in murine myoblasts through PDK1, which acts as a downstream effector in the PI3K/Akt/c-Jun signaling pathway and has been implicated in the regulation of neutrophil migration.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts

Wang

Liu

et al. 2017

Sci Rep

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Inflammatory myopathy is a rare autoimmune muscle disorder. Treatment typically focuses on skeletal muscle weakness or inflammation within muscle, as well as complications of respiratory failure secondary to respiratory muscle weakness. Impaired respiratory muscle function contributes to increased dyspnea and reduced exercise capacity in pulmonary hypertension (PH), a debilitating condition that has few treatment options. The initiation and progression of PH is associated with inflammation and inflammatory cell recruitment and it is established that hypoxia-induced mitogenic factor (HIMF, also known as resistin-like molecule α), activates macrophages in PH. However, the relationship between HIMF and inflammatory myoblasts remains unclear. This study investigated the signaling pathway involved in interleukin-18 (IL-18) expression and its relationship with HIMF in cultured myoblasts. We found that HIMF increased IL-18 production in myoblasts and that secreted IL-18 promoted tube formation of the endothelial progenitor cells. We used the mouse xenograft model and the chick chorioallantoic membrane assay to further explore the role of HIMF in inflammatory myoblasts and angiogenesis in vivo. Thus, our study focused on the mechanism by which HIMF mediates IL-18 expression in myoblasts through angiogenesis in vitro and in vivo. Our findings provide an insight into HIMF functioning in inflammatory myoblasts.

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Correlation of plasma interleukin-18 concentration and severity of renal involvement and disease activity in systemic lupus erythematosus

Cited by 28 publications

References 25 publications

Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells

Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis

Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts

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