Correlation of platelet indices with TIMI frame count in patients undergoing primary PCI due to ST-segment elevation myocardial infarction

Abstract

Introduction: Given the fundamental role of platelet indices in the development of atherosclerotic plaque, these indices may play a predictive role for the occurrence of disturbed coronary reperfusion. The present study evaluated the association between platelet indices and coronary reperfusion status based on the Thrombolysis in Myocardial Infarction (TIMI) frame count. Methods: This cross-sectional study was conducted on 98 consecutive patients with ST elevation myocardial infarction who were candidate for primary Percutaneous Coronary Intervention (PCI) at Modarres Hospital in Tehran between January 2016 and January 2018. Venous samples were extracted from all patients before primary PCI. To assess the condition of coronary reperfusion after primary PCI, the TIMI frame count related to culprit artery in acute myocardial infarction was determined. Results: The TIMI frame count was positively associated with platelet count (r = 0.320, P = 0.001) and more strongly with platelet to lymphocyte ratio (r = 0.375, P < 0.001), but not with other platelet indices such as platelet distribution width (PDW), mean platelet volume (MPV) or Platelet large cell ratio (PLCR). According to the ROC curve analysis, platelet to lymphocyte ratio was introduced as a valuable parameter for differentiating complete from disturbed reperfusion (AUC = 0.735, 95%CI: 0.613-0.858, P = 0.001). The best cutoff value for platelet to lymphocyte ratio in predicting disturbed reperfusion was 146.5 with a sensitivity of 81.8% and a specificity of 60.5%. However, other platelet indices could not present this predictive role. Conclusion: The platelet to lymphocyte ratio with predictive accuracy and sensitivity predicts coronary perfusion impairment based on the increase in TIMI frame count.

Association of Ejection Fraction with Reperfusion Parameters Before and After Primary Percutaneous Coronary Intervention

“…Research has shown that the relatively lower CTFC of infarcted arteries immediately after PCI can be associated with better improvement in left ventricular function (24)(25)(26). Although lower CTFC has been shown to be significantly associated with higher EF, our results did not show a significant correlation between these two parameters, suggesting that the link between these two parameters may be affected by other determinants.…”