Correlation of Polycystic Ovary Syndrome and Recurrent Miscarriage

Abstract

Background: Numerous studies have investigated the association between polycystic ovary syndrome (PCOS) and recurrent miscarriage (RM). Increased rates of PCOS have been reported for women with RM. However, the actual prevalence is controversially discussed by the scientific community and remains unclear, since a wide range of rates from 8-82% can be found in the literature. Objective: To assess the relation between polycystic ovary syndrome and recurrent miscarriage and to evaluate the prevalence of polycystic ovarian syndrome within the recurrent miscarriage population. Patients and method: It is a cross sectional conducted at the infertility clinic in the outpatient department of University Hospital from March 2019 to March 2020. Patient sample was 47 participant. Hormonal profile FSH, LH, TSH, TSH, assessment of glycemic status and insulin resistance and ultrasonography for diagnosis of polycystic ovaries were done to every patients. Result: There was high statistically significant relation between the PCO and total number of follicles, number of follicles ≥ 18 mm and endometrial thickness. There was high statistically significant relation between the PCO and testosterone hormones and statistically significant relation between the PCO and FSH and LH. There was no statistically significant relation between the PCO and insulin resistance. Conclusion: In this study we concluded that the prevalence of PCOS seems slightly increased in women with recurrent miscarriage, PCOS on the other hand showed a rather high prevalence compared to the general population.

Síndrome de ovario poliquístico, más allá de una afección en la reproducción.

“…La RI e hiperinsulinemia aumentan la secreción de andrógenos lo que puede provocar displasia folicular y dar lugar a óvulos de baja calidad, además, el hiperandrogenismo y la RI podrían inducir daños mediados por el desequilibrio entre las respuestas al estrés oxidativo y antioxidante en el útero grávido, lo cual se asocia con un alto riesgo de aborto. 42,43,44 Conforme avanza el embarazo, la mujer con SOP es propensa a la DMG, ya que diversos factores de riesgo característicos del síndrome se relacionan a esta complicación, principalmente la obesidad, el IMC elevado, la RI, así como la etnia e incluso la edad materna. El mecanismo del desarrollo de esta enfermedad aún no está claro, pero se sugiere que los niveles elevados de adipocinas y marcadores inflamatorios, así como el estrés oxidativo podrían exacerbar la RI.…”