Correlation of Positron Emission Tomography Standard Uptake Value and Pathologic Specimen Size in Cancer of the Head and Neck

Burri, Ryan J.; Rangaswamy, Balasubramanya; Kostakoğlu, Lale; Hoch, Benjamin; Genden, Eric M.; Som, Peter M.; Kao, Johnny

doi:10.1016/j.ijrobp.2007.10.055

Cited by 59 publications

(48 citation statements)

References 25 publications

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“…[2][3][4] Because current treatment protocols focus primarily on improving locoregional control, further gains in survival may come from improved treatment or the prevention of distant recurrence, second primary cancer, and comorbid medical illnesses. [15][16][17][18] In this article, we demonstrated that with highly effective locoregional therapy delivered by a dedicated multidisciplinary team, head and neck cancer patients now fail mostly at distant disease sites.…”

Section: Discussionmentioning

confidence: 99%

“…2 Although the optimal approach to clinical follow-up remains controversial, there is significant interest in the application of positron emission tomography (PET)/CT to overcome the limitations of physical examination or conventional imaging alone. [3][4][5] On the basis of previously published data suggesting that 18 F-fluorodeoxyglucose (FDG)-PET offers a more accurate assessment of therapy response and earlier detection of recurrent disease than conventional imaging, our group instituted a protocol incorporating PET/CT in the follow-up of patients with head and neck cancers in July, 2005. [6][7][8][9][10][11] The goals of this study were 1) to establish the diagnostic accuracy of follow-up PET/CT in the detection of locoregional recurrence, distant metastases, and second primary tumors; and 2) to determine the impact of PET/CT on the prognosis and management of suspected disease recurrence.…”

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confidence: 99%

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The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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Nitroxyl radicals were used as functionalizing agents during the free radical postreactor modification process of polyolefins carried out in the melt. The 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (HO‐TEMPO) and the 4‐benzoyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (BzO‐TEMPO) free radicals were successfully grafted onto a polyethylene‐based material (ethylene‐co‐1‐octene copolymer) by coupling reaction with polymer macroradicals; these last were formed by H‐abstraction through peroxide addition. The macromolecular structure of the functionalized polyolefins was assessed by 1H‐NMR, FTIR spectroscopy, and SEC measurements which were used to evidence the grafting site, to evaluate the grafting level and to highlight the occurrence of chain extension through crosslinking side reactions. Indeed the use of proper model compounds allowed the preparation of accurate FTIR calibration curves for the quantitative determination of the functionalization degree. Besides the high temperature SEC analysis highlighted that this fast and simple coupling reaction between macroradicals and nitroxyl free radicals grants the grafting of functionalities onto the polyolefin backbone by contemporarily preventing the side reactions liable of the structure and MW modification of the pristine polymer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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“…This method is commonly used (13)(14)(15)(16)(17) but is influenced by the display windowing and is dependent on operators. Therefore, several objective methods for contouring PET images have been Katoh 14 developed, including isocontouring based on a fixed threshold of a standardized uptake value (1,(17)(18)(19)(20), a fixed threshold of 40% to 50% of the maximum activity (3,17,(20)(21)(22), and a threshold adapted to the signal-to-background ratios (2,12,17). However, the appropriate standardized technique for the segmentation of PET images is still under investigation in the head and neck region (4)(5)(6)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma

Katoh

Yasuda

Shiga

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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SUMMARYTwo treatment planning methods for nasopharyngeal carcinoma (NPC) were compared: conventional whole-body BGO scintillator positron emission tomography (PET) (PET CONV WB) and a new brain PET system using semiconductor detectors (PET NEW BR). In this study, 12 patients with NPC were analyzed. The gross tumor volume (GTV) was visually delineated on PET images using either PET CONV WB or PET NEW BR. The average absolute volume of GTV contoured with the use of the new brain PET was significantly smaller than that of conventional whole-body BGO PET.Assuming a stereotactic radiotherapy boost plan of 7 ports, the plan using the new brain PET would significantly reduce the maximum dose to the cerebrum and cerebellum and brain stem. The new brain PET system using semiconductor detectors can provide more accurate tumor delineation than the conventional whole-body BGO PET system and has the potential to offer functional and molecular radiotherapy treatment planning.Katoh 4 ABSTRACT Purpose: We compared treatment planning of stereotactic boost for nasopharyngeal carcinoma (NPC) between using conventional whole-body BGO scintillator positron emission tomography (PET) (PET CONV WB) and using the new brain PET system using semiconductor detectors (PET NEW BR).Methods and Materials: The present study included 12 patients with NPC.18 F-fluorodeoxyglucose-PET images were acquired with both the PET NEW BR and a PET CONV WB on the same day. CT and two PET data sets were transferred to a treatment planning system, and the PET CONV WB and PET NEW BR images were co-registered with the same set of CT images. The window width and level for all PET images were fixed at 3000 and 300 respectively. The gross tumor volume (GTV) was visually delineated on PET images using either PET CONV WB images (GTV CONV ) or PET NEW BR images (GTV NEW ). Assuming a stereotactic radiotherapy boost of 7 ports, the prescribed dose delivered to 95% of the planning target volume (PTV) was set to 2000 cGy in 4 fractions.Results: The average absolute volume of GTV NEW was 15.7 ml (standard deviation; SD, 9.9), and that of GTV CONV was 34.0 ml (SD, 20.5). The average of GTV NEW was significantly smaller than that of GTV CONV (p=0.0006). There was no statistically Conclusion: The present study suggests that the new brain PET system using semiconductor detectors can provide more accurate tumor delineation than conventional whole-body BGO PET system and may be an important tool for functional and molecular radiotherapy treatment planning.

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“…5,31,[72][73][74]76,80 However, few groups have validated delineation process using different imaging modalities against surgical resection specimens. 31,[81][82][83][84][85] In general, all imaging modalities overestimated the tumour extension compared with surgical specimen. Nevertheless, none of the image modalities (CT, MRI or PET) completely encompassed the surgical specimen volume because of an underestimation of superficial tumour extension in the mucosa, 31 as also reported by Ng et al 81 According to Daisne et al, 31 the GTV delineated from 18 F-FDG-PET applying an adaptive signal-to-background method was significantly smaller than GTV delineated by CT or MRI.…”

Section: Radiotherapy Planningmentioning

confidence: 99%

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

Cacicedo¹,

Navarro²,

Hoyo³

et al. 2016

BJR

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Squamous cell carcinoma is the most common malignant tumour of the head and neck. The initial TNM staging, the evaluation of the tumour response during treatment, and the long-term surveillance are crucial moments in the approach to head and neck squamous cell carcinoma (HNSCC). Thus, at each of these moments, the choice of the best diagnostic tool providing the more precise and larger information is crucial. Positron emission tomography with fluorine-18 fludeoxyglucose integrated with CT ( 18

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Correlation of Positron Emission Tomography Standard Uptake Value and Pathologic Specimen Size in Cancer of the Head and Neck

Cited by 59 publications

References 25 publications

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

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