Correlation of Preoperative Level of Serum Ca125 with Surgical Staging of Ovarian Cancer

Abstract

Background: Ovarian cancer is one of the leading cause of mortality and morbidity of gynaecological malignancies. Lack of early demonstration of symptoms and lack of effective screening tests, ovarian tumours are usually diagnosed at an advanced stage. Different studies shows the association of pre-operative serum CA125 level with the surgical staging of ovarian cancer. Objective: To find out the correlation of pre-operative level of serum CA 125 with the surgical staging (FIGO-2014) of ovarian cancer. Methodology: This cross sectional study was carried out among 81 subjects in the department of gynaecological oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from August 2018 to September 2019. Sampling technique was purposive. All consecutive patients admitted at department of gynaecological oncology, BSMMU with diagnosed ovarian cancer were included in this study. Data were collected and documented on a preformed and pretested structured questionnaire. Clinical examinations and relevant investigations were done and recorded accordingly. Result: Mean age of the study subjects was 45.7 ± 15.2 years with a range of 13-75 years. Mean BMI was 23.3 ± 3.0 kg/m2 and mean age of marriage was 16.1 ± 2.8 years. Maximum study subjects had stage III (44.4%) followed by stage II (23.5%), stage I (21.0%) and stage IV (11.1%). Preoperative CA-125 was >35 U/ml in 90.1% cases. Serum CA-125 was elevated at the advanced stage of ovarian cancer. Maximum study subjects had serous tumors (70.4%) followed by mucinous tumors (11.5%), endometrioid adenocarcinoma (7.4%), malignant teratoma (4.9%) and clear cell tumors (3.7%). Serum CA-125 had significant positive correlation with surgical stages of ovarian epithelial cancer. Conclusion: Surgical stage of epithelial ovarian cancer significantly correlates with CA-125. Bangladesh Med Res Counc Bull 2021; 47(2): 110-117

Polymer-Based Terbium Complex as a Fluorescent Probe for Cancer Antigen 125 Detection: A Promising Tool for Early Diagnosis of Ovarian Cancer

“…While tumor markers, imaging techniques, and combined algorithms have been employed to differentiate benign from malignant epithelial OC, the search for improved sensitivity and specificity continues. , CA-125, the most commonly used biomarker for OC detection, faces limitations . While elevated levels in advanced stages make it valuable for postsymptomatic detection, its ambiguous results in early stages have led medical societies to advise against routine screening for average-risk women. , Despite its limitations, CA-125 remains crucial for monitoring treatment response, disease-free survival duration, and predicting prognosis. − The standard enzyme-linked immune sorbent assay (ELISA) method, while established, has limitations . The ELISA encounters three main limitations; first, the interfering compounds in the sample matrices can adversely impact the accuracy and precision of the assay.…”

“… 14 , 15 Despite its limitations, CA-125 remains crucial for monitoring treatment response, disease-free survival duration, and predicting prognosis. 16 − 22 The standard enzyme-linked immune sorbent assay (ELISA) method, while established, has limitations. 23 The ELISA encounters three main limitations; first, the interfering compounds in the sample matrices can adversely impact the accuracy and precision of the assay.…”