Correlation of preterm infant illness severity with placental histology

Chisholm, Karen M.; Heerema-McKenney, Amy; Tian, Lü; Rajani, Anand K.; Saria, Suchi; Koller, Daphne; Penn, Anna A.

doi:10.1016/j.placenta.2016.01.012

Cited by 30 publications

(24 citation statements)

References 51 publications

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“…5,6 Supporting the fetus through the progressive pregnancy, the placenta is a unique and valuable organ in explaining the pathogenesis of preterm birth. 5,6 Placental histological and microbiological assessment reveals different pathological findings in association with gestational age and neonatal morbidity.…”

Section: Discussionmentioning

confidence: 99%

“…IUGR was identified by serial ultrasonography scans including biometric and Doppler measurements. 6 IVH was diagnosed by cranial ultrasonography shortly after delivery. 6 The diagnosis of RDS, HIE and sepsis was confirmed by clinical and laboratory assessments.…”

Section: Methodsmentioning

confidence: 99%

“…6 IVH was diagnosed by cranial ultrasonography shortly after delivery. 6 The diagnosis of RDS, HIE and sepsis was confirmed by clinical and laboratory assessments. 6 All the grades of IUGR, IVH, RDS, HIE and sepsis were deemed as either absent or present since the lack of data for individual analyze of the results for each grade.…”

Section: Methodsmentioning

confidence: 99%

“…5 Induced preterm birth is defined when the labor is induced or caesarean section is performed for maternal or fetal indications. 5,6 Histological chorioamnionitis is the most common lesion reported in placenta in spontaneous preterm births. 5,6 While in almost 30 % of cases a clinical cause is not identified.…”

mentioning

confidence: 99%

“…5,6 Histological chorioamnionitis is the most common lesion reported in placenta in spontaneous preterm births. 5,6 While in almost 30 % of cases a clinical cause is not identified. 5,7 Nevertheless, it is clear that placental pathology has been implicated in the pathogenesis of preterm birth and neonatal morbidity.…”

mentioning

confidence: 99%

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Correlation between placental pathology and neonatal morbidity: a case-control study

Kornete

Vedmedovska

Blazuka

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Preterm births occur in approximately 12% of pregnancies worldwide and in 5.6% of pregnancies in Latvia, and the incidence has increased. Prematurity poses the major challenge in perinatology and pediatrics, accounting for 75% of perinatal mortalities and 50% of long-term complication. The placenta is a unique organ in explaining the incomprehensible pathogenesis of prematurity.Methods: The retrospective case-control study was conducted to determine placental histological and microbiological findings associated with gestational age and neonatal morbidity.Results: Histological chorioamnionitis was the most prevalent lesion in extremely preterm and very preterm birth groups compared with moderate to late preterm and term birth groups (P=0.027). A higher rate of funisitis was detected among extremely preterm and very preterm birth cases (P=0.001). Microbiological examination of placentas in preterm birth cases most commonly revealed Streptococcus agalactiae, Staphylococcus epidermidis, Staphylococcus haemolyticus. Umbilical cord vessels thrombosis and placental thrombotic vasculopathy were found mostly in moderate to late preterm birth category (P=0.032; P=0.008, respectively). Intrauterine growth restriction was linked to chorionic villous edema (P=0.007) and chorionic villous fibrinoid necrosis (P=0.014). Chorion-decidual hemorrhage and deciduitis were significantly associated with respiratory distress syndrome (P=0.036; P=0.022, respectively). Chorion-decidual hemorrhage was the main predisposing factor for hypoxic-ischemic encephalopathy (P=0.058).Conclusions: Comprehension of the pathogenic mechanisms of prematurity of the placenta and preterm births, and the impact of placental prematurity on neonatal morbidity may lead to improved prenatal diagnostic and enhanced preventive care for both the mother and the child.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Correlation between placental pathology and neonatal morbidity: a case-control study

Kornete

Vedmedovska

Blazuka

2017

Int J Reprod Contracept Obstet Gynecol

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Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

et al. 2019

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Key PointsQuestionIs chorioamnionitis a risk factor for developing bronchopulmonary dysplasia in preterm infants?FindingsThis systematic review, meta-analysis, and metaregression found that chorioamnionitis was associated with an increased risk of bronchopulmonary dysplasia in preterm infants but also found significant differences in baseline characteristics between infants with and infants without chorioamnionitis. A multivariate metaregression model combining the difference in gestational age and the odds of respiratory distress syndrome was associated with 64% of the variance in the association between chorioamnionitis and bronchopulmonary dysplasia.MeaningExposure to chorioamnionitis is associated with a higher risk of developing bronchopulmonary dysplasia in preterm infants, but this association may be modulated by gestational age and risk of respiratory distress syndrome.

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Fetal akinesia deformation sequence and massive perivillous fibrin deposition resulting in fetal death in six fetuses from one consanguineous couple, including literature review

Tjon

Lakeman

Leeuwen

et al. 2021

Molec Gen & Gen Med

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Correlation of preterm infant illness severity with placental histology

Abstract: Introduction-A major goal of neonatal medicine is to identify neonates at highest risk for morbidity and mortality. Previously, we developed PhysiScore (Saria et al., 2010), a novel tool for

Cited by 30 publications

References 51 publications

Correlation between placental pathology and neonatal morbidity: a case-control study

Correlation between placental pathology and neonatal morbidity: a case-control study

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

Fetal akinesia deformation sequence and massive perivillous fibrin deposition resulting in fetal death in six fetuses from one consanguineous couple, including literature review

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