Correlation of Proliferative Marker Ki-67 With World Health Organization Histological Classification and Grading of Meningiomas.

Abstract

Background: CNS tumors are heterogenous variety of tumors and brain parenchyma is the most common site of CNS tumors, followed by meninges, sellar region and nerves. Meningiomas arise from meningothelial cells of the arachnoid and are attached with the duramater. WHO grading based on the histopathololgical features, alone has limitations in predicting the exact behavior of meningiomas. Hence, the use of immunohistochemical markers like Ki-67 helps in determining the aggressive nature of the tumor and its recurrence potential. To correlate Aim: the signicance of proliferative marker Ki-67 with histological classication and grading of meningiomas cases were taken. Material and Method: A cross-sectional study carried out in the Department of Pathology at Maharaja Agrasen Medical College Agroha, Hisar with sample size of 35 biopsies/excision specimens of meningiomas cases. In the present study, Result: female outnumbered male with female:male ratio of 1.7:1 and mean age of 48 years. Out of 35 cases, 30 cases (85.7%) were of grade I and 5 (14.3%) were of grade II. No case of grade III meningioma was recorded. Mean Ki-67 LI was 6.40±14.21 in grade I and 19.60±12.88 in grade II. So, grade II had signicantly more mean Ki-67 LI compared to grade I and was statistically signicant with p value <0.05. IHC evaluation Conclusion: with Ki-67 LI do add information to the routine histopathological evaluation of meningiomas, and helps in assessing the biological behaviour of meningiomas and in formulating the suitable treatment plan for various grades of meningiomas and follow up of cases as early as possible. So, the use of Ki-67 LI in the histomorphological study of meningiomas is a supplement in determining the histological grade, not a substitute and is of signicance for appropriate management.