Correlation of Reduced PTGER3 Expression with Prognosis and Immune Infiltration in Clear Cell Renal Carcinoma

Yang, Kang; Hu, Bin; Zeng, Guohua; Yuan, Dongbo; Wang, Wei; Su, Hao; Liu, Heng; Zhu, Jianguo

doi:10.56434/j.arch.esp.urol.20237604.31

Cited by 2 publications

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“…This study identified a total of 337 DEGs between high-TMB and low-TMB cases of breast cancer (193 with high expression in the high-TMB group and 144 with high expression in the low-TMB group), of which 54 were related to immune function, including seven that were of prognosis predictive value. The predictive utility of these seven genes was validated against TIMER 2.0 and the GEPIA database, confirming that FABP7 , PTGER3 , CXCL14 , and TMSB15A were all associated with higher or lower OS, consistent with previous studies ( 38 - 41 ). To investigate the MFs of these immunity-associated DEGs, we performed functional enrichment analysis of GO terms and KEGG pathways, which showed that they mainly played roles in cellular chemotaxis, granulocyte migration and humoral immunity, extracellular matrix and receptor ligand activity, and binding to G protein-coupled receptors; these results are consistent with previous reports ( 42 ).…”

Section: Discussionsupporting

confidence: 82%

Tumour mutation burden and infiltrating immune cell subtypes influenced the breast cancer prognosis

Li,

Liu,

Han

et al. 2024

Transl Cancer Res

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Background Most of its issues are still undecided on the relationship between tumour mutation burden (TMB) and immune-related genes in the breast cancer. This study explores their relationship based on gene mutation and transcription data in The Cancer Genome Atlas (TCGA) database, and the effects of immune cells in TMB and tumour microenvironments on prognosis of breast cancer patients. Methods Cases were divided into low-TMB and high-TMB subgroups. Differentially expressed immune-related genes were identified in different TMB subgroups, and patient prognosis was predicted by gene function enrichment analysis, invasive immune cells and different clinical pathological features were compared among different TMB subgroups. Results A total of 986 mutation data from breast cancer patients were obtained. Compared with low-TMB group, the survival period of high-TMB group was relatively longer. A total of 337 differential expression genes were identified in this study. Of these genes, seven differentially expressed immune-related genes were associated with prognosis. In the high-TMB group, activated CD4+ memory T cells and other cells had high expression, the expression ratio of memory B cells and other cells in low-TMB group was high. Conclusions TMB-related immunological infiltration characteristics showed meaningful value for prognosis prediction for breast cancer patients. Differentially expressed immune-related genes in TMB subgroups provide important information on the survival prediction.

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Section: Discussionsupporting

confidence: 82%

Tumour mutation burden and infiltrating immune cell subtypes influenced the breast cancer prognosis

Li,

Liu,

Han

et al. 2024

Transl Cancer Res

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Glycerophosphoinositol modulates FGA and NOTCH3 in exercise-induced muscle adaptation and colon cancer progression

Luo,

Ding

et al. 2024

Front. Pharmacol.

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ObjectivesFibroleukin (FGA) and NOTCH3 are vital in both exercise-induced muscle adaptation and colon adenocarcinoma (COAD) progression. This study aims to elucidate the roles of FGA and NOTCH3 in phenotypic variations of striated muscle induced by exercise and in COAD development. Additionally, it seeks to evaluate the prognostic significance of these proteins.MethodsGene Set Variation Analysis (GSVA) and protein-protein interaction (PPI) network analysis were employed to identify differentially expressed genes (DEGs). Molecular docking studies were conducted to assess the binding affinities of 39 compounds to the NOTCH3 protein. In vitro assays, including mobileular viability, gene expression, and apoptosis assays, were performed to evaluate the effects of glycerophosphoinositol on FGA and NOTCH3 expression. Additionally, copy number variation (CNV), methylation status, and survival analyses were conducted across multiple cancers types.ResultsThe NOTCH signaling pathway was consistently upregulated in exercise-induced muscle samples. High NOTCH3 expression was associated with poor prognosis in COAD, extracellular matrix organization, immune infiltration, and activation of the PI3K-Akt pathway. Molecular docking identified gamma-Glu-Trp, gamma-Glutamyltyrosine, and 17-Deoxycortisol as strong binders to NOTCH3. Glycerophosphoinositol treatment modulated FGA and NOTCH3 expression, influencing cell proliferation and apoptosis. CNV and methylation analyses revealed specific changes in FGA and NOTCH3 across 20 cancers types. Survival analyses showed strong associations between FGA/NOTCH3 expression and survival metrics, with negative correlations for FGA and positive correlations for NOTCH3.ConclusionFGA and NOTCH3 play significant roles in exercise-induced muscle adaptation and colon cancer progression. The expression profiles and interactions of these proteins provide promising prognostic markers and therapeutic targets. These findings offer valuable insights into the post-translational modifications (PTMs) in human cancer, highlighting novel pharmacological and therapeutic opportunities.

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Correlation of Reduced PTGER3 Expression with Prognosis and Immune Infiltration in Clear Cell Renal Carcinoma

Cited by 2 publications

References 0 publications

Tumour mutation burden and infiltrating immune cell subtypes influenced the breast cancer prognosis

Tumour mutation burden and infiltrating immune cell subtypes influenced the breast cancer prognosis

Glycerophosphoinositol modulates FGA and NOTCH3 in exercise-induced muscle adaptation and colon cancer progression

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