Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema

Abstract

Aim To determine whether significant correlations exist between retinal sensitivity measured by fundus-related microperimetry and the visual acuity and the foveal thickness measured by optical coherence tomography (OCT) in eyes with diabetic macular edema (DME). Methods A retrospective chart review of 32 eyes with DME and 17 normal healthy eyes that had undergone fundus-related microperimetry and OCT. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, Micro Perimeter 1. The mean retinal sensitivities within the central 21 and 101 were correlated with the best-corrected visual acuity and OCT-measured foveal retinal thickness. Results The mean sensitivities in the central 21 and 101 were significantly lower in patients with DME than in normal subjects (Po0.0001). The mean retinal sensitivities in the central 21 and 101 were inversely correlated with visual acuity (r 2 ¼ 0.623, Po0.0001; r 2 ¼ 0.581, Po0.0001) and foveal thickness (r 2 ¼ 0.581, Po0.0001; r 2 ¼ 0.551, Po0.0001). Conclusions The mean retinal sensitivities measured with fundus-related microperimetry were significantly lower in eyes with DME than in normal eyes. Because a significant correlation of the microperimeter-determined retinal sensitivity to visual acuity and foveal thickness was observed, the retinal sensitivities obtained by fundus-related microperimetry may be another measure that can be used to assess the effects of DME.

Functional and morphological changes of macula after subthreshold micropulse diode laser photocoagulation for diabetic macular oedema

“…9 Similar results were also reported by Vujosevic et al 10 We had concluded that the retinal sensitivity may be another measure that can be used to assess the effects of DMO. In both studies, the patients with DMO had not undergone any treatment for their macular oedema; however, in this study, the results of SMDLP on the VA and retinal sensitivity were different.…”

“…We have reported that the retinal sensitivity of the macular area determined by fundus-related microperimetry, MP1 (Nidek, Japan), was significantly correlated with the VA and foveal retinal thickness, and suggested that this may provide another method to assess the effects of DMO. 9 Similar findings were also reported, 10 and it was suggested that microperimetry may be of value in predicting the outcome of DMO. 10 The purpose of this study was to determine the retinal sensitivity of the macula area with the MP1 in patients with DMO treated with SMDLP, and to compare the retinal sensitivity with the best corrected visual acuity (BCVA) and the foveal thickness (FT) measured by optical coherence tomography (OCT).…”

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

“…Although there are reports evaluating central macular function in subjects with diabetic macular oedema using microperimetry with scanning laser ophthalmoscope, 23 fundus-related microperimeter 24 and multifocal ERG, 25 correlation of decreased retinal sensitivity as a corollary to reduced retinal thickness (in participants with no clinical diabetic retinopathy or maculopathy), as measured on spectral domain OCT and MP has not been reported earlier.…”

Interexaminer and intraexaminer reliability of the microperimeter MP-1

“…36 Significant correlations between mean retinal sensitivities measured by the MP-1, the foveal thickness in the OCT, and visual acuity were found in a retrospective chart review of patients with DME. 38 Vujosevic et al 36 compared the changes in macular sensitivity and macular thickness in different degrees of DME. They found macular sensitivity to be a relevant explanatory variable of visual function, independent of macular thickness data.…”