Correlation of salivary neopterin and plasma fibrinogen levels in patients with chronic periodontitis and/or type 2 diabetes mellitus

Abstract

<jats:title>Abstract</jats:title><jats:p>Neopterin is a novel predictor for coronary events especially in diabetic patients and also an indicator for the effectiveness of the periodontal treatment. In this study, we assessed whether salivary neopterin can be used as a potential biomarker in evaluating the risk of cardiovascular disease in type 2 diabetic patients with chronic periodontitis. Forty subjects between 25 and 75 years of age and who matched the criteria were selected and divided into four groups. Their periodontal status was evaluated. Stimulated whole saliva and blood were collected for analysis of salivary neopterin and fibrinogen and HbA<jats:sub>1c</jats:sub> levels, respectively. Nonsurgical periodontal therapy was carried out. Patients were recalled after 3 months, and the same procedure was repeated. A reduction in all the parameters was seen after treatment in all the four groups. Salivary neopterin levels showed significant difference (p&lt;0.001) in the values between the study groups and the control group before treatment. After 3 months of treatment, salivary neopterin levels showed a statistical significant reduction (p&lt;0.001) in all the study groups. Neopterin could serve as an effective tool to assess the inflammatory process related to periodontitis and diabetes mellitus and also predict future cardiovascular events in diabetic patients.</jats:p>

Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

“…After periodontal treatment in individuals with moderate to severe periodontitis, a drastic decrease (from 51 nmol/l to 1.77 nmol/l) in the level of GCF neopterin concentrations was observed [89]. Similar results have also been reported in other studies on patients with periodontitis [607, 608], as well as in patients with a combination of periodontitis and/or DM [609]. On the other hand, a study by Bodur et al (2003) [610] reported no significant differences in both pre- and post-periodontal treatment-GCF neopterin levels between the group of patients with AgP and periodontally healthy controls.…”

Neopterin Levels in Periodontitis and after Nonsurgical Periodontal Therapy: Evaluation of Gingival Crevicular Fluid, Oral Fluid, Serum and Urinary Samples—A Case-Control Study

“…OF samples revealed a significant increase in Np levels after periodontal therapy. This is in contradiction with previous studies [ 8 , 13 , 14 , 30 ]. Ozmeric et al [ 8 ] suggested that Np in OF may originate mainly from the salivary gland as a result of nitric oxide production.…”

“…OF samples revealed a significant increase in Np levels after periodontal therapy. This is in contradiction with previous studies [8,13,14,30].…”

“…Several previous studies found significantly higher Np concentrations in the GCF [ 9 , 11 , 12 ] and oral fluid of subjects with periodontitis [ 15 , 30 ]. Periodontal therapy was associated with a decrease in Np levels [ 9 , 11 , 14 , 18 , 30 ].…”

“…Several previous studies found significantly higher Np concentrations in the GCF [ 9 , 11 , 12 ] and oral fluid of subjects with periodontitis [ 15 , 30 ]. Periodontal therapy was associated with a decrease in Np levels [ 9 , 11 , 14 , 18 , 30 ]. In our study, when the Np levels in the study group before periodontal treatment were compared with the control group, only GCF TA and urinary NC were significantly higher in the study group.…”