Correlation of <scp>ALDH</scp>1, <scp>CD</scp>44, <scp>OCT</scp>4 and <scp>SOX</scp>2 in tongue squamous cell carcinoma and their association with disease progression and prognosis

Huang, Cong-Fa; Xu, Xiaorong; Wu, Tianfu; Sun, Zhi‐Jun; Zhang, Wenfeng

doi:10.1111/jop.12159

Cited by 87 publications

(117 citation statements)

References 36 publications

(44 reference statements)

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“…[ [15][16][17][18] Etiological differences may have contributed to this result. In addition, majority of the tumors in the present study sample contained buccal mucosal cancers; while the literature quoted above have focused on tongue cancers.…”

Section: Discussionmentioning

confidence: 69%

“…In addition, majority of the tumors in the present study sample contained buccal mucosal cancers; while the literature quoted above have focused on tongue cancers. [16,18] Furthermore, Sox-2 expression has been shown to be related to poor survival at sites such as esophagus and bladder as well. [19,20] In addition, problems highlighted below concerning survival data may have also contributed to this result.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Jayasooriya¹,

Fernando²,

Suraweera³

et al. 2017

SDS

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Jayasooriya¹,

Fernando²,

Suraweera³

et al. 2017

SDS

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“…These findings are not in agreement with the results of this study showing that CD44 and CD44v9 were abundantly expressed in OSCC. Many reports investigated the CD44 expression rate (50~80%) and relationship between CD44s expression and clinicopathological factors (28,29). However, the results of these studies have been conflicting.…”

Section: Discussionmentioning

confidence: 99%

Expression of CD44, CD44v9, ABCG2, CD24, Bmi‑1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors

et al. 2018

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Abstract. Cancer stem cells (CSCs) exhibit self-replication, self-differentiation, drug resistance and immune evasion activities. In recent years CSCs have become increasingly important for the treatment of malignant tumors. CSCs express specific markers, including cluster of differentiation (CD)44, CD44 variant 9 (CD44v9), ATP-binding cassette sub-family G member 2 (ABCG2), CD24, B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) and aldehyde dehydrogenase 1 (ALDH1). However, the prognostic value of their expression in patients with oral squamous cell carcinoma (OSCC) are not well known. The present study evaluated these markers in stage I and II patients with OSCC and examined the association between T classification, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. Tissue specimens were obtained from 70 patients with stage I or II OSCC following either surgery or biopsy. Immunohistochemistry was performed and positive staining was defiend as 10% positive cells. CD44 and CD44v9 expressions were strongly detected in all OSCC tissues compared with normal epithelial cells. A total of 22 (31.4%) cases expressed ABCG2 and there was a significant association between ABCG2 expression and invasion. A total of 41 cases (59.0%) expressed CD24 and there was a significant association between CD24 expression and invasion. A total of 33 cases (47.1%) expressed BMI-1 and there was a significant association between BMI-1 expression and the disease-free survival rate. A total of 18 cases (25.7%) expressed ALDH1.Although there was no association between ALDH1 expression and T classification, there were significant associations between ALDH1 expression and histological differentiation, invasion mode, metastasis and the disease-free survival rate. Multivariate analysis revealed that ALDH1 expression was the only prognostic factor for disease-free survival rate. The results of the present study suggest that the positivity of ALDH1 detected in patients with OSCC correlates with the number of cells undergoing epithelial mesenchymal transition and metastasis. These findings indicated that the expression of ALDH1 may be an effective prognostic marker indicating the survival of patients with stage I and II OSCC. IntroductionCancer stem cells (CSCs) are functionally defined by their extensive self-renewal capacity. CSC confers increased radioand chemoresistance in tumors, resulting in tumor recurrence and metastatic spread. Therefore, identification of the regulators that control the tumorigenic potential of CSCs might provide new therapeutic strategies against CSCs to improve cancer treatment. The CSC theory suggests that only a few cancer cells with a capacity for high tumorigenicity, self-renewal, and differentiation are responsible for the maintenance and growth of tumors. Similar to normal tissue stem cells, CSCs can also exist within a supportive niche (1).Oral squamous cell carcinoma (OSCC) patients in stage I and II are mainly treated by surgery and almost all...

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“…Several studies have revealed that the SOX2 proteins were overexpressed in the TSCC, and demonstrated that SOX2, recurrence and distant metastasis were independent prognostic factors of overall survival in patients with TSCC. Therefore the studies concluded that the expression of SOX2 may be used as a prognostic indicator of TSCC (82). SOX2 was exclusively expressed in the CSCs of OSCC patients and the expression of SOX2 was significantly associated with a poor prognosis of OSCC and lymph node status, which indicates the potential prognostic value of SOX2 in OSCC.…”

Section: Sox2 In Osccmentioning

confidence: 99%

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Ren

Zhang

2016

Oncology Letters

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Abstract. Oral squamous cell carcinomas (OSCCs) are a growing problem in the world. The various existing treatments have not markedly improved the survival rate of patients with OSCC during the past three decades. Novel treatment strategies are required. Sex determining region Y-box 2 (SOX2) is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. SOX2 expression was indicated to act as a prognostic factor in various types of tumors, including breast, colorectal, gastric and lung cancer and glioblastoma, and as a link between malignancy and stemness. Cancer stem cells (CSCs) may be responsible for the genesis, growth and metastatic spread of tumors. The poor survival outcomes for OSCC patients may be attributable to a poor selection of target cells for treatment, as current oral cancer therapies are generally aimed at the global mass of tumor. Therefore, the consideration that novel approaches to oral cancer may be targeted using SOX2 and CSCs appears reasonable. In order to better understand the oncogenic roles and the corresponding signal transduction pathways of the SOX2 protein, the present study emphasizes the role of SOX2 in OSCC, including the proteins associated with OSCC, and reviews the literature regarding the role of SOX2 in lymph node metastasis. The aim of the present study is to provide a reference for future studies that engage in research on the aforementioned subject.

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Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis

Abstract: Taken together, these data suggest that the stem cell markers ALDH1, CD44, OCT4 and SOX2 are closely related in TSCC, and the expression of SOX2 can be used as a prognostic indicator of TSCC.

Cited by 87 publications

References 36 publications

Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Stem cell markers as a resource to predict prognosis of betel quid induced oral squamous cell carcinoma: an immunohistochemical investigation

Expression of CD44, CD44v9, ABCG2, CD24, Bmi‑1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

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