Correlation of Seizure Increase and COVID-19 Outbreak in Adult Patients with Epilepsy: Findings and Suggestions from a Nationwide Multi-centre Survey in China

Zeng, Chang; Meng, Hongmei; Zhu, Yulan; Yao, Lifen; Lian, Yajun; Zhu, Yanmei; Zhang, Min; Dai, Yuwei; Wang, Kang; Han, Xing; Li, Ling; Zhang, Lifang; Xu, Hongbo; Yao, Dongai; Liu, Xiang; Jiang, Wen; Wang, Xiahong; Zhao, Chuansheng; Chen, Yangmei; Deng, Xuejun; Liu, Chaorong; Feng, Li; Song, Yue; Wu, Yuan; Liao, Wei‐Ping; Wang, Furong; Zhu, Suiqiang; Xiao, Bo; Wang, Qun; Long, Lili

doi:10.1016/j.seizure.2021.03.029

Cited by 22 publications

(23 citation statements)

References 31 publications

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“…Epilepsy patients constituted a small proportion in both groups, and the majority of them had cerebral involvement. Increased seizure frequency and new-onset seizures during COVID-19 have been reported previously, and our data were similar to these [ 30 , 31 ].…”

Section: Discussionsupporting

confidence: 93%

Analysis of neurology consultations in hospitalized patients with COVID-19

et al. 2022

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Objective The aim of this study was to evaluate patients who were hospitalized with a diagnosis of COVID-19 and were consulted by neurology during their hospital stay. Methods All files of patients with COVID-19 who were admitted to Cerrahpasa Medical Faculty Hospital between March 11th and December 31st, 2020 were retrospectively reviewed, and files of patients who consulted by neurology during their stay were included. Demographic and clinical characteristics, neurologic diagnosis, outcome and related laboratory data were extracted from electronic medical records and analyzed. Patients were categorized into the first wave and second wave according to the date of hospitalization. Results A total of 2257 patients were hospitalized for COVID-19; among them, 127 were consulted by a neurologist during their hospital stay. Fifteen patients received a consultation for possible drug interactions. Among the remaining 112 patients, the reason for neurology consultation was i. exacerbation of a neurological comorbidity vs ii. new-onset neurological manifestations. The median age was 68.5 ± 14.2 years, and 60.7% were men. Dementia and stroke were the leading neurological comorbidities. COVID-19 disease was more severe in the patients with the new-onset neurological comorbidity than in patients with exacerbation of a neurological comorbidity ( p = 0.07). Serum creatinine kinase levels were higher in the new-onset patient group ( p < 0.05). Exacerbation of previous neurological disease or new neurological impairment were jointly and severely related to high mortality (overall 35/112 vs 275/2145, p < 0.001; exacerbation 12/45 vs 275/2145 p < 0.01; new-onset 23/67 vs 275/2145, p < 0.001). Conclusion Serious neurological involvement is relatively uncommon in hospitalized patients with COVID-19 and is associated with increased mortality.

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Section: Discussionsupporting

confidence: 93%

Analysis of neurology consultations in hospitalized patients with COVID-19

et al. 2022

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“…Tre studier viste at henholdsvis 8 %, 25 % og 27 % av deltagerne opplevde økt anfallsfrekvens under pandemien. Stress, angst, søvnmangel, depresjon, mindre fysisk aktivitet, dårligere livskvalitet og bekymring for å bli hospitalisert eller for å oppleve mangel på legemidler ble anført som grunn (7)(8)(9).…”

Section: Kan Epilepsi Forverres Av Covid-19?unclassified

Covid-19 og epilepsi

Berger¹,

Henning²,

Svalheim³

et al. 2021

Tidsskriftet

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Kjell Heuser er ph.d., overlege og forsker ved Nevrologisk avdeling, Oslo universitetssykehus, Rikshospitalet. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. TONI CHRISTOPH BERGER Toni Christoph Berger er lege ved Nevrologisk avdeling, Oslo universitetssykehus, Rikshospitalet og ph.d.-stipendiat ved Universitetet i Oslo. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. OLIVER HENNING Oliver Henning er ph.d. og overlege ved Spesialsykehuset for epilepsi, Oslo universitetssykehus. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. SIGRID SVALHEIM Sigrid Svalheim er ph.d. og overlege ved Nevrologisk avdeling, Oslo universitetssykehus, Rikshospitalet. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. JØRN MANDLA SIBEKO Jørn Mandla Sibeko er assisterende generalsekretaer i Epilepsiforbundet. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. KARL O. NAKKEN Karl O. Nakken er pensjonert nevrolog. Han var i mange år medisinsk ansvarlig ved Spesialsykehuset for epilepsi, Oslo universitetssykehus. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. ERIK TAUBØLL Erik Taubøll er professor, overlege og forskningsleder ved Nevrologisk avdeling, Oslo universitetssykehus, Rikshospitalet. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.Kan covid-19 forårsake epilepsi eller øke anfallstendensen hos dem som har epilepsi? Og er det trygt for personer med epilepsi å ta vaksine mot covid-19?

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“…Subjektif olan bu anamnezlerin daha objektif olması için ve nöbetlerin doğasındaki değişkenlik nedeni ile COVID-19 sonrasında, öncesine göre nöbet sıklığında ≥%50 artış olan hastalar, nöbet sıklığında artış olan grupta değerlendirildi. [14,15] Nöbet şiddetinin artışında hastanın COVID-19 hastalığı sonrasında öncesine göre artış olup olmadığı subjektif olarak araştırıldı. [16] Aynı şekilde subjektif olan bu hasta değerlendirmesinin daha objektif olması için fokal başlangıçlı nöbetlerde fokalden bilateral tonik klonik nöbete geçiş olması ve myoklonik ve absans nöbetlerde jeneralize tonik klonik nöbete geçiş hikayesi olması, nöbet şiddetinde artış olarak kabul edildi.…”

Section: Gereç Ve Yöntemunclassified

“…Cinsiyet, yaş ve nö-bet sınıflamasının da COVID-19 sürecinde epilepsi hastalığının seyri üzerine etkisi bulunmadığı tespit edilmiştir ve bu durum literatür ile uyumludur. [14,16] Çalışmanın limitasyonları, retrospektif planlanması nedeni ile, hastaların COVID-19 sürecinde elektroensefalograf bulgularının olmayışı, uzun süreli verilerin henüz hastalık süresinin yeni olması nedeni elde edilememiş olması, uykusuzluk, anksiyete gibi nöbet üzerine etkisi olabilecek faktörlerin değerlendirilmemiş olması ve tarif edilen nöbetlerin hasta ve yakınlarından elde edilen anamneze göre değerlendirilmesi nedeni ile subjektif değerlendirilmiş olmasıdır. Ancak daha önceki çalışmalar dikkate alınarak veriler objektif olarak değerlendirilmeye çalışılmıştır.…”

Section: İstatiksel Analiz-unclassified

“…Ancak daha önceki çalışmalar dikkate alınarak veriler objektif olarak değerlendirilmeye çalışılmıştır. [14][15][16][17] Literatürde, COVID-19 sonrası nöbetlerin seyri ile ilgili bilgi, hastalığın yeni olması nedeni ile henüz yoktur. Genellikle pandemi süresinde COVID-19 geçirmemiş epilepsi hastalarının nöbetlerinin seyri ile ilgili bilgiler mevcuttur.…”

Section: İstatiksel Analiz-unclassified

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COVID-19 Geçiren Epilepsi Hastalarında Nöbet Sıklığı ve Şiddetinin İncelenmesi

Altun¹,

Ílknur²,

Güray³

et al. 2021

Epilepsi

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Objectives: Coronavirus disease (COVID-19) causes various neurological manifestations such as seizure and alteration of consciousness. The effect of COVID-19 on epilepsy is limited. For this reason, it was aimed to investigate the effect of COVID-19 on seizure frequency and severity of patients with epilepsy and the effect of COVID-19 treatment on seizures. Methods: Patients followed by the epilepsy outpatient unit were evaluated for COVID-19 between April 2020 and April 2021 and the patients who had COVID-19 were undertaken to the study. The age, gender, epilepsy type, duration of epilepsy, seizures in the past year, comorbidity disease, the date of COVID-19, COVID-19 treatment, inpatient care, need of intensive care, seizures in the meantime, treatment of antiepileptic drugs (AED), and seizure frequency and severity after COVID-19 were evaluated retrospectively. Results: A total of 141 patients who were diagnosed with COVID-19 were recruited for the study. When evaluating the factors which affect seizure occurrence risk during COVID-19, it was found that COVID-19 treatment protocol did not affect, but the existence of seizure in the past year increased 4.002 times, need for inpatient care increased 12.481 times, and number of AED increased 1.974 times seizure risk. It was found that having seizure during COVID-19 increased after COVID-19 seizure frequency and severity. Conclusion:As a result, the data of the study showed that the factors which affect having seizure during COVID-19 were inpatient care, the number of AED, and existence of seizure in the past year. The studies which included larger patients and longer follow-up time data are needed to evaluate the longer effect of COVID-19 on epilepsy.

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Correlation of Seizure Increase and COVID-19 Outbreak in Adult Patients with Epilepsy: Findings and Suggestions from a Nationwide Multi-centre Survey in China

Cited by 22 publications

References 31 publications

Analysis of neurology consultations in hospitalized patients with COVID-19

Analysis of neurology consultations in hospitalized patients with COVID-19

Covid-19 og epilepsi

COVID-19 Geçiren Epilepsi Hastalarında Nöbet Sıklığı ve Şiddetinin İncelenmesi

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