Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns

Palcevska-Kocevska, Snezana; Aluloska, Natasa; Krstevska, Marija; Shukarova-Angelovska, Elena; Kojik, Ljiljana; Zisovska, Elizabeta; Kocevski, Dragoslav; Kočova, Mirjana

doi:10.2298/sarh1210595p

Cited by 17 publications

(8 citation statements)

References 21 publications

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“…The positive association detected in this study between the leptin concentration in the maternal serum and umbilical cord and neonatal anthropometric measurements confirms what was reported in the previous studies [9,17,30,50]. Schubring et al [30] detected a significant correlation between leptin levels in the umbilical vein and artery and birth weight of the neonates.…”

Section: Discussionsupporting

confidence: 91%

“…As other studies have reported, in our study the mean leptin concentrations were also higher in female neonates than in male neonates even though the birth weight in both sexes was similar. This may suggest participation of sex hormones in leptin secretion [17,50,51]. This is contrary to the study results published by Palcevska-Kocevsa et al [50], who found no differences in the leptin concentrations between the male and female infants.…”

Section: Discussioncontrasting

confidence: 58%

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Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Skórzyńska-Dziduszko

et al. 2019

IJMS

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Two-thirds of pregnant women exceed gestational weight gain recommendations. Excessive gestational weight gain (EGWG) appears to be associated with offspring’s complications induced by mechanisms that are still unclear. The aim of this study was to investigate whether umbilical cord leptin (UCL) and ghrelin (UCG) concentrations are altered in full-term neonates born to EGWG mothers and whether neonatal anthropometric measurements correlate with UCL and UCG levels and maternal serum ghrelin and leptin as well as urine ghrelin concentrations. The study subjects were divided into two groups, 28 healthy controls and 38 patients with EGWG. Lower UCL and UCG levels were observed in neonates born to healthy mothers but only in male newborns. In the control group UCG concentrations correlated positively with neonatal birth weight, body length and head circumference. In the control group maternal serum ghrelin levels correlated negatively with neonatal birth weight, body length and head circumference as well as positively with chest circumference. In the EGWG group UCG concentrations correlated negatively with neonatal birth weight and birth body length. UCL correlated positively with birth body length in EGWG group and negatively with head circumference in the control group. In conclusion, EGWG is associated with disturbances in UCL and UCG concentrations.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 58%

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Skórzyńska-Dziduszko

et al. 2019

IJMS

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“…Our study in newborns showed that leptin and adiponectin levels were positively correlated with all anthropometric parameters: body weight, body length, BW/BL, BMI, and the pondered index (p<0.01). These results indicate that the stage of body growth maturity is positively correlated to adipocytokines involved in fetal growth regulation, as previously reported ( 27 , 36 , 37 ). SGA newborns have the riskiest metabolic profile among all other newborn groups.…”

Section: Discussionsupporting

confidence: 90%

Metabolic Setup and Risks in Obese Children/Metabolički Profil I Rizici Kod Gojazne Dece

Kočova¹,

Sukarova-Angelovska²,

Tanaskoska³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackgroundIn the past decades, the obesity epidemic in children of all ages has been an important research field for detecting the metabolic causes and consequences of obesity, the major focus being on insulin and adipocytokine levels. Metabolic work-up in obese children is recommended in the age group as young as 2–6 years. There is evidence that birth weight can be a factor causing obesity later in life accompanied by metabolic complications.MethodsInsulin, leptin, and adiponectin levels were analyzed in 269 obese children and 60 controls, as well as 110 newborn children with different birth weight and different length of gestation, using standard methods.ResultsIn 53.6% of the obese children, complications of obesity such as diabetes mellitus, obesity, hyperlipidemia, heart attack or stroke were found in family members. The peak insulinemia on OGTT was significantly higher in the pubertal compared to the prepubertal group (110.5± 75.9 μU/mL versus 72.2±62.7 μU/mL) (p<0.005). Glucose intolerance was confirmed in 24%. The leptin level was significantly higher and the adiponectin level was lower in pubertal obese children compared to the prepubertal children and controls (p<0.05). In newborns the leptin and adiponectin levels were in correlation with anthropometric parameters: body weight (BW), body length (BL), BW/BL, BMI, and the pondered index (p<0.05).ConclusionObese children have high insulinemia in all ages, reaching its peak towards puberty. The leptin and adiponectin levels might be indicators of the metabolic syndrome. Our findings in newborns might influence the nutritional approach in the future in order to prevent complications of obesity.

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“…Child adiponectin levels at birth and birth weight have been examined in the previous studies however, were inconsistent. Volberg et al reported no relations (Volberg et al 2013), while the others reported positive association between cord MINATOYA 5 blood adiponectin levels with birth weight (Mantzoros et al 2009) and the association between lower adiponectin and small for gestational age (SGA) and preterm birth (Palcevska-Kocevska et al 2012;Yeung et al 2015). A progressively significant negative association between adiponectin and BMI at 2, 5, and 9 years of age has been reported (Volberg et al 2013).…”

Section: Minatoyamentioning

confidence: 99%

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Minatoya

Itoh

Miyashita

et al. 2017

Environmental Research

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Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4ng/mL, respectively. The median total adiponectin and leptin levels were 19.4μg/mL and 6.2ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.

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Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns

Abstract: Significantly higher adiponectin levels were found in AGA neonates compared to SGA neonates. Leptin and adiponectine levels were positively correlated with birth weight. These findings suggest that these adipocytokines may be involved in fetal growth regulation.

Cited by 17 publications

References 21 publications

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Metabolic Setup and Risks in Obese Children/Metabolički Profil I Rizici Kod Gojazne Dece

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

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