Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Bi, Xiaoning

doi:10.1186/s13018-018-0959-y

Cited by 36 publications

(43 citation statements)

References 35 publications

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“…The baseline analysis and biochemical parameters revealed that OA patients have signi cant higher concentration of CRP, COMP, MMP-13, TGF-β1 and Gas6 compared to control group (Table 1). These ndings are inline of several other studies indicate that these biochemical parameters involved in osteoarthritis development and treatments [25][26][27][28][29]. In addition, we observed that serum AXL level in OA patients was signi cantly higher compared with that in the healthy control (Fig.…”

Section: Discussionsupporting

confidence: 91%

Increased Serum AXL Is Associated With Knee Osteoarthritis Severity

Zhenghai¹

2021

Preprint

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Objective: Serum AXL expression and clinical significance in patients with knee osteoarthritis (KOA). Methods: 183 patients with knee osteoarthritis were selected and divided based on the Kellgren-Lawrence (KL) score into KL 0 subgroups (n = 42), KL I-II subgroups (n = 90), and KL III-IV subgroups (n = 51). Healthy volunteers (n= 170) in our hospital were selected as the control group. AXL level in serum was detected by enzyme-linked immunosorbent assay (ELISA). The correlation between serum AXL with severity and clinical indicators of osteoarthritis was analyzed. Results: The level of serum AXL was significantly higher in the osteoarthritis group than that in the control group (P<0.05). In the osteoarthritis patients, serum AXL level was increased with the increase of KL score. Serum AXL level was positively correlated with age, body mass index (BMI), erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), cartilage oligomeric protein (COMP), matrix metalloproteinase-13 (MMP-13), and transforming growth factor-β1 (TGF-β1) levels. The cut-off value for serum AXL was determined as 33.375 ng/mL by receiver operating curve (ROC) analysis. Conclusion: The level of serum AXL in patients with osteoarthritis is abnormally high, which is closely related to the severity of osteoarthritis.

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Section: Discussionsupporting

confidence: 91%

Increased Serum AXL Is Associated With Knee Osteoarthritis Severity

Zhenghai¹

2021

Preprint

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“…The serum COMP is one of the most extensively studied cartilage markers so far and researchers have found an association between increased COMP & progression in rheumatoid arthritis. Increased cartilage turnover is re lected upon as raised serum COMP levels, therefore used as a prognostic marker of cartilage breakdown in con irmed RA patients (Bi, 2018). But different from these observations in our study, there is not much signi icant change in the amount of COMP in RA patients when compared with controls, shows the degree of uncertainty on the role of COMP in RA pathogenesis.…”

Section: Cartilage Oligomeric Matrix Protein ( Comp)contrasting

confidence: 86%

Study of serum traditional and nontraditional biomarkers in Rheumatoid arthritis patients

Vinod¹,

Chand²,

Preeti³

et al. 2020

ijrps

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The study of biomarkers in Rheumatoid arthritis (RA) is highly indispensable to understand mechanisms of pathogenesis, diagnosis, prognosis, and treatment of disease. The role of traditional biomarkers like Anti-CCP, RF, and inflammatory markers like ESR and CRP is well established. In this study, we aimed to measure nontraditional biomarkers like Hyaluronic acid (HA), Cartilage oligomeric matrix protein (COMP), and Osteocalcin in the serum of RA patients and also to establish an association with traditional markers. It was a cross-sectional study involving 152 RA patients based on the 1987 ACR criteria for the diagnosis of RA and 68 age‑ and sex-matched healthy controls. After the clinical examination, traditional markers were assessed to measure the disease activity along with non traditional markers in RA patients. All the values were expressed as median (25th–75th percentile). In our study, there was a significant increase in serum HA levels in RA patients compared to healthy controls (p < 0.03), whereas no significant difference in serum COMP and osteocalcin levels. The traditional inflammatory markers were significantly increased in RA patients than controls with (p < 0.001). The serum HA levels were significantly correlated with traditional markers in RA patients. Conclusion: Significant increase in serum HA level in RA patients indicating synovial inflammation, but there were no notable changes in COMP and osteocalcin level in serum presuming the combination of these markers may be useful along with traditional markers in the different stages of RA.

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“…COMP is a logical consideration for a biomarker of OA as it is a noncollagenous glycoprotein, is expressed in articular cartilage, 32 and serum levels of COMP have been shown to be significantly elevated in patients with knee OA. 33,34 COMP is mechanosensitive 11 and believed to play a role in supporting extracellular matrix interactions in cartilage needed for its load-bearing function. 35 COMP is released in response to damage in the cartilage matrix, and it has been suggested that OA may result in more active cartilage turnover, resulting in higher serum COMP levels.…”

Section: Discussionmentioning

confidence: 99%

Changes in knee adduction moment wearing a variable‐stiffness shoe correlate with changes in pain and mechanically stimulated cartilage oligomeric matrix levels

Erhart‐Hledik

Mahtani

Asay

et al. 2020

Journal Orthopaedic Research

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This study aimed to determine if changes in knee adduction moment (KAM) after 6 months of variable‐stiffness shoe wear are associated with changes in symptoms or serum levels of cartilage oligomeric matrix protein (COMP) following a mechanical stimulus in subjects with medial knee osteoarthritis (OA). Twenty‐five subjects were enrolled in the study and assigned a variable‐stiffness shoe, and 19 subjects completed the 6‐month follow‐up. At baseline and follow‐up subjects underwent gait analysis in control and variable‐stiffness shoes, completed Western Ontario and McMaster Universities (WOMAC) questionnaires, and serum COMP concentrations were measured immediately before, 3.5 and 5.5 hours after a 30‐minute walking activity. Relationships between changes in KAM (first peak and impulse) and changes in (a) COMP levels in response to the 30‐minute walking activity and (b) WOMAC scores from baseline to 6‐month follow‐up were assessed by Pearson correlation coefficients. Changes in first peak KAM were associated with changes in COMP levels 5.5 hours postactivity from baseline to follow‐up (R = .564, P = .045). Subjects with greater reductions in KAM had larger decreases in COMP (expressed as a percent of preactivity levels) at follow‐up. Subjects with greater reductions in KAM impulse had significantly greater improvements in WOMAC Pain (R = −.56, P = .015) and Function (R = −.52, P = .028) scores at follow‐up. The study results demonstrated the magnitude of reduction in the KAM wearing a variable‐stiffness shoe is associated with decreases in mechanically stimulated COMP levels and pain/function. This work suggests that interactions between COMP and joint loading during walking should be further investigated in future studies of treatment outcomes in OA.

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Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Cited by 36 publications

References 35 publications

Increased Serum AXL Is Associated With Knee Osteoarthritis Severity

Increased Serum AXL Is Associated With Knee Osteoarthritis Severity

Study of serum traditional and nontraditional biomarkers in Rheumatoid arthritis patients

Changes in knee adduction moment wearing a variable‐stiffness shoe correlate with changes in pain and mechanically stimulated cartilage oligomeric matrix levels

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