Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study

Chutani, Arun; Pande, Sonali

doi:10.5455/njppp.2017.7.0515606052017

Cited by 28 publications

(30 citation statements)

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“…Therefore, the elevated levels of serum urea were likely due to the glomerular and tubular damage. Similar results were revealed by other studies [ 36 , 38 ] where serum urea was significantly raised in diabetic subjects. Conversely, the administration of AD, diminished serum concentration of urea in treated diabetic rats, especially the 400 mg/KgBW treatment which reduced serum urea by 22.5%.…”

Section: Discussionsupporting

confidence: 92%

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Alabi

Brooks

Oguntibeju

2021

Plants

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Kidney disease in diabetes is one of the common microvascular complications of diabetes mellitus implicated in end-stage renal failure. This study explored the ability of Anchomanes difformis to ameliorate kidney and pancreatic damage in type 2 diabetes mellitus using male Wistar rats. Two weeks of fructose (10%) administration followed by streptozotocin (40 mg/kg) were used to induce type 2 diabetes. Leaf extract (aqueous) of Anchomanes difformis (200 mg and 400 mg/kgBW) was administered orally for six weeks. Body weights were monitored, urea and creatinine were measured. Interleukins (IL)-1β, IL-6, IL-10, IL-18, and TNFα were measured in the kidney lysate. CAT, SOD, ORAC, FRAP, and MDA levels were also evaluated in the kidney. Transcription factors (Nrf2 and NF-ĸB/p65) and apoptotic markers (Bcl2 and caspase 3) were investigated in the kidney. Histological sections of the pancreas and kidney tissues were examined for any visible pathology. Supplementation with Anchomanesdifformis enhanced antioxidant status, modulated inflammatory response, and reduced apoptosis in the kidney. It also restored the kidney and pancreatic histoarchitecture of the treated diabetic rats. The pathophysiology associated with diabetic nephropathy and pancreatic damage showcase the importance of exploring the use of antidiabetic, nephroprotective agents such as Anchomanes difformis to kidney damage in type 2 diabetes.

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Section: Discussionsupporting

confidence: 92%

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Alabi

Brooks

Oguntibeju

2021

Plants

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“…For example, in 2009, Harita et al [75] confirmed that low serum creatinine levels were associated with an increased risk of type 2 diabetes mellitus and dysglycemia. This was also confirmed in the recent studies conducted by Takeuchi et al [76] and Chutani and Pande [77]. Creatinine is produced after the pyrophosphate cleavage of phosphocreatine to produce energy for muscle activity.…”

Section: Discussionsupporting

confidence: 75%

A Preliminary Study Showing the Impact of Genetic and Dietary Factors on GC–MS-Based Plasma Metabolome of Patients with and without PROX1-Genetic Predisposition to T2DM up to 5 Years Prior to Prediabetes Appearance

Mojsak

Miniewska

Godlewski

et al. 2021

CIMB

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Risk factors for type 2 diabetes mellitus (T2DM) consist of a combination of an unhealthy, imbalanced diet and genetic factors that may interact with each other. Single nucleotide polymorphism (SNP) in the prospero homeobox 1 (PROX1) gene is a strong genetic susceptibility factor for this metabolic disorder and impaired β-cell function. As the role of this gene in T2DM development remains unclear, novel approaches are needed to advance the understanding of the mechanisms of T2DM development. Therefore, in this study, for the first time, postprandial changes in plasma metabolites were analysed by GC–MS in nondiabetic men with different PROX1 genotypes up to 5 years prior to prediabetes appearance. Eighteen contestants (12 with high risk (HR) and 6 with low risk (LR) genotype) participated in high-carbohydrate (HC) and normo-carbohydrate (NC) meal-challenge tests. Our study concluded that both meal-challenge tests provoked changes in 15 plasma metabolites (amino acids, carbohydrates, fatty acids and others) in HR, but not LR genotype carriers. Postprandial changes in the levels of some of the detected metabolites may be a source of potential specific early disturbances possibly associated with the future development of T2DM. Thus, accurate determination of these metabolites can be important for the early diagnosis of this metabolic disease.

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“…This can occur because an increase in blood sugar levels usually begins after the age of forty when the kidneys are unable to filter glucose in the long term and other chronic kidney triggers, such as hypertension, dyslipidemia, and obesity. This study is in accordance with research conducted by Arun Chutani and Sonali Pande in 2017 which states there is no correlation between HbA1c levels with cardar ureum and there is no correlation between HbA1c levels with creatinine levels [9].…”

Section: Discussionsupporting

confidence: 92%

The Correlation between the levels of HbA1c with Ureum and Creatinine in Patient with Type 2 Diabetes Mellitus

Prasetyorini

Sudiro

Mujianto

et al. 2019

AJAS

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Introduction and Aims : Untransmitted diseases is the leading cause of death globally. Diabetes mellitus is one of the four priorities of untransmitted diseases. This disease is a chronic disease characterized by blood glucose levels that exceed normal values. High blood sugar levels (hyperglycemia) will cause various complications, one of which is chronic complications that can attack various organs such as eyes, kidneys, nerves and blood vessels. This study aims to find out the correlation between the results of the examination of HbA1c, urea and creatinine levels which is an indicator of complications of Chronic Kidney Failure in Type 2 DM patients.Â Methods : This research is a survey research using cross-sectional study design. The respondents in this study are Type 2 DM patients who filled out the questionnaire and examined levels of HbA1c, ureum, and creatinine. Analysis of the data performed by using the SPEARMEN test SPSS for Windows 17.Â Result : The result of the SPEARMEN analysis is p = 0,016 (p < 0.05) which means there is a relationship between the levels of HbA1c with age of respondent. Meanwhile, p = 0,84 (p>0,05) which means there is no relationship between HbA1c levels of type 2 DM with urea levels of type 2 DM patients. While, there is no relationship between HbA1c levels of type 2 DM with creatinine levels of type 2 DM with p = 0.693 (p > 0,05).Â Conclusions : There is a correlation between HbA1c levels of type 2 diabetes mellitus with the age of the respondent, but there is no correlation between HbA1c levels of type 2 diabetes mellitus with ureum levels of type 2 diabetes mellitus and there is no correlation between HbA1c levels with Creatinine levels of Â type 2 diabetes mellitus patients.

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Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study

Cited by 28 publications

References 0 publications

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

A Preliminary Study Showing the Impact of Genetic and Dietary Factors on GC–MS-Based Plasma Metabolome of Patients with and without PROX1-Genetic Predisposition to T2DM up to 5 Years Prior to Prediabetes Appearance

The Correlation between the levels of HbA1c with Ureum and Creatinine in Patient with Type 2 Diabetes Mellitus

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