Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome

Abstract

ABSTRACT. Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development and plaque rupture. In this study, the correlation of hs-CRP and IL-6 was investigated in patients with acute coronary syndrome (ACS). Sixty cases of ACS, including 33 cases of acute myocardial infarction (AMI) and 27 cases of unstable angina pectoris (UAP), 45 cases of stable angina pectoris (SAP), and 45 healthy people (HG) were enrolled in study. The serum hs-CRP and serum IL-6 levels were tested by the immune turbidimetric method and enzyme-linked immunosorbent assay (ELISA), respectively. The differences among groups and their correlations were evaluated. Results showed that the serum hs-CRP and IL-6 concentrations of the AMI and UAP groups were significantly higher than those of the SAP and HG groups, respectively (P < 0.01), and those of the AMI group were significantly higher than those of the UAP group (P < 0.05). The serum hs-CRP and IL-6 levels of the ACS Correlation of C-reactive protein and interleukin-6 group were positively correlated (r = 0.836). The serum hs-CRP and IL-6 levels could be used to determine the stability of plaque, and have some relevance in the ACS process, showing great value in judgments of ACS prognosis.

Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

“…CRP and IL‐6 are plasma inflammatory markers that increase with aging heart (Franceschi & Campisi, ). Usually, their secretion could be predictive of subsequent cardiovascular events such as acute coronary syndrome (Wang, Liu, Wang, & Jin, ). It has been demonstrated that resveratrol suppresses the secretion of proinflammatory cytokines in murine macrophages by modulating NF‐κB signaling pathway (Ma, Wang, Dong, Li, & Cai, ).…”

Diagnostic and prognostic value of biomarkers in acute myocardial infarction

“…The former is involved in inflammatory cell activation and recruitment, and stimulates the liver to produce acute-phase proteins such as CRP while exerting a negative inotropic effect through myocardial nitric oxide synthase (NOS). Wang et al 55 found that IL-6 was related to the procession of ACS and had prognostic use. Serum IL-6 was shown to be useful for predicting mortality in patients with ACS51 and identifying individuals who could benefit from targeted interventional or intensive therapy 56.…”

High-resolution imaging of complex aortic plaques in ischemic stroke patients using 3.0 Tesla MRI with VISTA

“…In this study, the following results were assessed: correlation of high signal resolution along the vessel wall with hs-CRP and the frequent tendency of CAP and high CAM score in the high signal lesion positive group. The high value of hs-CRP in the positive group might reflect inflammatory change focused on the plaque lesions [7]. The high frequency of CAP and high CAM score were also evidence of an association of CAP and high signal resolution along the thoracic aorta on MRI.…”