Correlation of serum levels of Vitamin D3 with serum parathormone in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan

Mustafa, Ghulam; Khalid, Muhammad; Ahmed, Ijaz; Talib, Muhammad Abu

doi:10.12669/pjms.36.5.2150

Cited by 2 publications

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“…In our study, we found that among euglycemic obese women, though PTH and calcium levels were negatively correlated significantly ( r = −0.267, P = 0.008), their individual negative correlation with vitamin D was not significant. Such noncustomary relation between vitamin D, PTH, and calcium is also reported among Pakistani women in other studies [ 13 , 14 ].…”

Section: Discussionsupporting

confidence: 81%

“…Vitamin D deficiency and increased concentration of PTH [ 11 ] as well as calcium [ 12 ] are implicated in the augmented risk of diabetes. This is especially relevant to Pakistani subjects as they are reported to have low vitamin D, high PTH, and increased calcium level with nonconventional relation between vitamin D, PTH, and calcium [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose

Saleem

Rizvi

Elahi

2021

BioMed Research International

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Background and Objective. Association of vitamin D (25-hydroxyvitamin-D; 25(OH)D), with glucose metabolism is ethnic dependent. We study the relation of vitamin D and its metabolites with the glycemic profile of obese women. Patients and Methods. Informed consent and demographic information was collected from obese ( BMI ≥ 30 kg / m 2 ) and nonobese women. A blood sample in fasting was obtained and analyzed for fasting glucose, fasting insulin, serum 25(OH)D, serum parathyroid hormone (PTH), and calcium levels. Insulin resistance (IR), detected by Matthews’ method (1985), was considered in women with HOMA − IR ≥ 2.5 . Vitamin D concentrations < 12 ng / ml were considered vitamin D deficiency. Results. A total of 264 obese and 133 normal BMI women (controls) of age range 20-50 years were selected. Obese women had significantly lower vitamin D compared to control women ( P < 0.05 ). Among euglycemic ( fasting glucose < 100 mg / dl ) obese women ( n = 221 ), 90 (40.7%) were vitamin D deficient. Serum PTH and calcium levels were negatively correlated, though nonsignificantly with vitamin D ( r = − 0.172 , P = 0.090 , and r = − 0.051 , P = 0.557 , respectively). The mean age, BMI, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), fasting glucose, fasting insulin, PTH, and calcium were not significantly different in vitamin D-deficient as compared to nondeficient obese women. IR was detected in 109 (49.3%) obese women. Mean HOMA-IR in vitamin D-deficient women was significantly higher than that in the nondeficient obese women ( 3.03 ± 1.64 vs. 2.40 ± 1.02 ; P = 0.041 ), but the percentage of women with IR was comparable in both groups (51.1% vs. 45.8%; P = 0.745 ). Univariate analysis revealed that HOMA-IR was negatively correlated with vitamin D and positively with BMI and PTH. A multivariate regression analysis, stepwise method revealed that BMI and PTH were independent determinants of HOMA-IR instead of vitamin D. Conclusion. More than 40% of obese women were vitamin D deficient. Among euglycemic obese women, 49% were insulin resistant. Prevalence of insulin resistance, though negatively correlated with vitamin D, could be better explained by BMI and PTH levels.

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Section: Discussionsupporting

confidence: 81%