Correlation of serum parathyroid hormone with mineral bone disease in chronic kidney disease patients

Vhora, Rajeshwari S; Munde, Anil; Bale, Charan; Kakrani, Arjun Lal

doi:10.4103/0975-2870.169947

Cited by 3 publications

(5 citation statements)

References 1 publication

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“…No statistically significant association was seen between anemia and the level of microcytosis and the development of SHPT that was similar to the results of Vhora et al [22]. Again, as with anemia; there was no statistically significant association between gender and the SHPT, and this was similar to Levin et al [18].…”

Section: Discussionsupporting

confidence: 80%

“…We could not deduce any significant relationship between age and the future SHPT that may be due to our small sample size. Vhora [22] and Kumchev et al [23][24][25] had the same results of nonsignificant correlation of age to the SHPT and investigated similar age ranges and means, concluding that it was statistically not significant when compared with the prevalence of SHPT in other study groups.…”

Section: Discussionsupporting

confidence: 56%

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Predictors of Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 4

Mansour¹,

Swaid²

2017

Endocrinol Metab Syndr

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 56%

Predictors of Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 4

Mansour¹,

Swaid²

2017

Endocrinol Metab Syndr

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“…In a similar study of 60 patients conducted by Rajeshwari S. Vhora et al, 96% of the patients showed increased parathyroid hormone levels. 8 Mean value of parathyroid hormone in all patients of CKD was 131.2±59 pg/ml and mean value in patients with hyperparathyroidism was 156.68±51 pg/ml. In a similar study conducted by by Luca De Nicola et al, mean value of serum parathyroid hormone in CKD patients was 102 pg/ml.…”

Section: Parathyroid Hormone Statusmentioning

confidence: 87%

“…9 In another study conducted by Rajeshwari S. Vhora et al, mean value of serum parathyroid hormone in patients of secondary hyperparathyroidism was 162±37 pg/ml. 8 This indicates secondary hyperparathyroidism is very common in CKD patients.…”

Section: Parathyroid Hormone Statusmentioning

confidence: 99%

Study of evaluation and correlation of calcium and phosphorus in chronic kidney disease with reference to parathyroid hormone

et al. 2020

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Background: Recent guidelines for bone metabolism and disease in CKD recommend that, the target levels for calcium (Ca), phosphorus (P), calcium x phosphorus product(Ca × P) and parathyroid hormone (PTH) levels should be maintained at 8.8-10.2 mg/dl, 2.1-5.6 mg/dl, < 57.1mg2/dl2 and 8.7-79.6 pg/ml, respectively in patients of CKD.Methods: This was an observational study done in 70 patients, presenting in outpatient and inpatient department of tertiary care multi-specialty teaching hospital. Study was carried out at Dhiraj Hospital, Vadodara, Gujarat, in interval of one and half year.The study was investigation based, in the age group of 18 years and above who presented with chronic kidney disease. Serum Ca and serum P levels were measured by Fully Automated Colorimetry and Parathyroid hormone was measured by FLIA-fluoroscence linked immunoassay.Results: Among the 70 patients of chronic kidney disease, 55.7% showed abnormal calcium levels, 41.4% showed abnormal phosphorus levels,72.9% showed abnormal PTH levels,11.4% showed abnormal Ca x P levels.Conclusions: The correlation between the phosphorus and PTH was linear and statistically significant. But the correlation between calcium and PTH was statistically insignificant and between Ca x P and PTH was very weak and statistically insignificant in CKD patients.

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“…Vhora et al [21] observed that out of 60 CKD patients, 55% had hypertension and diabetic nephropathy together.…”

Section: Resultsmentioning

confidence: 99%

“Alterations in Parathormone, Calcium and Phosphorus Levels in CKD Patients on Maintenance Haemodialysis in a Hospital Setting in Punjab.”

Bansal

Gahlot

Prasher

et al. 2017

Asian J Pharm Clin Res

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Objective: Many people who have severe chronic kidney disease (CKD) will eventually develop kidney failure and will require dialysis. The control of parathormone (PTH), phosphorus, and calcium metabolism is one of the objectives in an adequate dialysis protocol. Therefore, we conducted this study to describe alterations in PTH, calcium, and phosphorous homeostasis in patients with CKD on hemodialysis in our center. Our study also aimed to find an association between hormonal and biochemical abnormalities in CKD patients, who have been on hemodialysis for ≥5 months and comparing the results obtained with that recommended by Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Methods:This was a hospital-based cross-sectional observational study. The study population of 330 patients (>18 years) on maintenance hemodialysis coming to dialysis Unit of Department of Medicine of Gian Sagar Hospital, Ramnagar (Patiala), over a period of 3 years (2012)(2013)(2014)(2015), were enrolled in the study. Each patient was considered only once for the study. In addition, biochemical analysis of serum intact PTH (iPTH), corrected calcium, phosphorus, total alkaline phosphatase (tALP), serum creatinine, blood urea, serum albumin, and hemoglobin of all cases was done using fully automated equipment. All statistical analyses were performed using SPSS statistical software, version 17. Results:The study population of 330 patients comprised adults, mainly illiterate (54.5%) predominantly belonging to the rural (66.4%) strata with a mean age of 52.67±15.05 (range: 25-98 years). The abnormality in the laboratory profile of the patients was found to be hyperparathyroidism in 40.3% as compared to hypoparathyroidism in 33.5% and normal iPTH levels in 26.2%. Hypocalcaemia was detected in 50.6% and hyperphosphatemia in 62.1% of the patients. There was statistically significant association of serum iPTH, with corrected calcium and phosphorus (P=0.032 and P=0.035, respectively). Corrected calcium was also significantly associated with phosphorus (P=0.001) and tALP (P=0.007). Conclusion:We showed in the present study that disorders of mineral metabolism are common in hemodialysis patients and that only a small proportion adheres to the targets as advised in the KDIGO guidelines for bone metabolism and disease in CKD. We demonstrated that these disorders are associated with important negative clinical outcomes, such as increased all-cause lack survival, more muscle and bone problems. Our findings, therefore, support a strict control of mineral metabolism in dialysis patients. Further research and progress in this area are required to establish a more rational approach with a view toward improving patient outcomes.

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Correlation of serum parathyroid hormone with mineral bone disease in chronic kidney disease patients

Cited by 3 publications

References 1 publication

Predictors of Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 4

Predictors of Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 4

Study of evaluation and correlation of calcium and phosphorus in chronic kidney disease with reference to parathyroid hormone

“Alterations in Parathormone, Calcium and Phosphorus Levels in CKD Patients on Maintenance Haemodialysis in a Hospital Setting in Punjab.”

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