Correlation of Serum Procalcitonin, Lactate Levels With Microbial Pattern in Patients With Sepsis

Abstract

Sepsis is defined as life -threatening organ dysfunction due to dysregulated host response to infection. To ensure a better outcome early identification of sepsis and a goal directed therapy is must .The objective of the study is to identify the correlation between levels of Serum Procalcitonin and Blood lactate with culture positive sepsis. This is a Retrospective and Prospective study that included 78patients admitted in Chettinad Hospital And Research Institute withSepsis . Procalcitonin with a cut off value of 2.4 ng/ml shows a significant correlation with culture positive bacterial infection, AUROC (0.759, p value of 0.002) sensitivity, specificity of 69.8%, 73.3% respectively. Blood samples were drawn at time of admission before initiation of treatment and were processed within 30 minutes of collection using an autoanalyser. Serum Procalcitonin, Lactate was done to all subjects included in the study. Analysis of Serum Procalcitonin was done using immunochromatographic test. The findings suggested that higher procalciton in levels are found to be significantly correlated with bacterial infection, especially Gram negative bacterial infection, when compared with Lactate. Procalcitonin levels can be used as predictor of bacterial infection; especially Gram negative bacterial infection even before obtaining culture results, so early effective empirical antibiotics can be started.