Correlation of serum ANA and direct immunofluorescence studies in elderly Thai patients with red and white oral lesions

Abstract

Elderly patients with red and white oral lesions who were taking medications had a higher serum ANA frequency than group I and the control group.

Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

“…17 Indeed, in our experience, red and white lesions that are similar to OLP lesions could be manifestations of other uncommon oral diseases. Therefore, lesions with the characteristics, as reported by oral pathologists, compatible with a diagnosis of OLP and a DIF evaluation with negative findings should be paid careful attention.…”

Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

“…However, it can be very challenging to diagnose and treat lesions, particularly when a patient takes multiple medications and when the oral lesion erupted is unclear. Therefore, history taking and complete oral examination, including direct immunofluorescence (DIF), are useful for the differential diagnosis of OLP or OLL from other red and white oral lesions . In OLP, immunoreactants with fibrinogen at the basement membrane zone (BMZ) show a shaggy pattern whereas immunoglobulin (Ig)M, IgA or C3 deposit in cytoid or colloid bodies .…”

“…Therefore, DIF assays need to be evaluated to clarify their use in obtaining a definitive diagnosis or prognosis. A previous study showed that red and white oral lesions in elderly patients could be diagnosed as OLP/LE, chronic ulcerative stomatitis (CUS)‐like lesion or immune complex‐mediated diseases …”

“…Most Thai patients with OLDR take multiple medications, such as hypolipidemics and antihypertensives . Oral hypoglycemics, non‐steroidal anti‐inflammatory drugs (NSAIDs) and antimalarials can also cause OLDR .…”

Challenges in using topical calcineurin inhibitors as a treatment for recalcitrant oral lichen planus

“…6 In a recent study, most recalcitrant OLP presented with red and white lesions that, using direct immunofluorescence, could possibly be diagnosed as lichen planus/lupus erythematous (lupus erythematous could not be ruled out), chronic ulcerative stomatitis-like lesions or immune complex mediated disease. 7 Therefore, long-term follow-up of recalcitrant OLP is recommended because the initial diagnosis of OLP may develop into another overlapping disease diagnosis in the future. Given that OLP is a common chronic disease in middle and old age, attention should be paid to the medications being taken in the context of oral lesions.…”