Correlation of skeletal muscle blood oxygenation level‐dependent MRI and skin laser doppler flowmetry in patients with systemic sclerosis

Partovi, Sasan; Schulte, Anja‐Carina; Staub, Daniel; Jacobi, Bjoern; Aschwanden, Markus; Walker, Ulrich A.; Imfeld, Stephan; Brož, Pavel; Benz, David; Zipp, Lisa; Takes, Martin; Jäger, K; Huegli, Rolf W.; Bilecen, Deniz

doi:10.1002/jmri.24503

Cited by 11 publications

(3 citation statements)

References 21 publications

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“…2006b; Partovi et al. , ), and is in close agreement with near infrared spectroscopy (NIRS) measures of blood volume and saturation following maximal muscle contractions (Towse et al. ).…”

Section: Introductionsupporting

confidence: 64%

Comparison of regional skeletal muscle tissue oxygenation in college athletes and sedentary control subjects using quantitative BOLD MR imaging

et al. 2016

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Blood oxygen level‐dependent (BOLD) magnetic resonance (MR) imaging permits noninvasive assessment of tissue oxygenation. We hypothesized that BOLD imaging would allow for regional evaluation of differences in skeletal muscle oxygenation between athletes and sedentary control subjects, and dynamic BOLD responses to ischemia (i.e., proximal cuff occlusion) and reactive hyperemia (i.e., rapid cuff deflation) would relate to lower extremity function, as assessed by jumping ability. College football athletes (linemen, defensive backs/wide receivers) were compared to sedentary healthy controls. BOLD signal of the gastrocnemius, soleus, anterior tibialis, and peroneus longus was assessed for peak hyperemic value (PHV), time to peak (TTP), minimum ischemic value (MIV), and time to recovery (TTR). Significantly higher PHVs were identified in athletes versus controls for the gastrocnemius (linemen, 15.8 ± 9.1%; defensive backs/wide receivers, 17.9 ± 5.1%; controls, 7.4 ± 3.5%), soleus (linemen, 25.9 ± 11.5%; backs/receivers, 22.0 ± 9.4%; controls, 12.9 ± 5.8%), and anterior tibialis (linemen, 12.8 ± 5.3%; backs/receivers, 12.6 ± 3.9%; controls, 7.7 ± 4.0%), whereas no differences in PHV were found for the peroneus longus (linemen, 14.1 ± 6.9%; backs/receivers, 11.7 ± 4.6%; controls, 9.0 ± 4.9%). In all subject groups, the gastrocnemius and soleus muscles exhibited the lowest MIVs during cuff occlusion. No differences in TTR were found between muscles for any subject group. PHV of the gastrocnemius muscle was significantly and positively related to maximal vertical (r = 0.56, P = 0.002) and broad jump (r = 0.47, P = 0.01). These results suggest that BOLD MR imaging is a useful noninvasive tool for evaluating differences in tissue oxygenation of specific muscles between active and sedentary individuals, and peak BOLD responses may relate to functional capacity.

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“…2006b; Partovi et al. , ), and is in close agreement with near infrared spectroscopy (NIRS) measures of blood volume and saturation following maximal muscle contractions (Towse et al. ).…”

Section: Introductionsupporting

confidence: 64%

Comparison of regional skeletal muscle tissue oxygenation in college athletes and sedentary control subjects using quantitative BOLD MR imaging

et al. 2016

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“…A correlation of BOLD MRI and skin laser Doppler flowmetry has been reported (Partovi et al, 2014). In their study, arterial occlusion produced a similar time courses in LDF signals and BOLD signals with a rapid LDF signal dropout.…”

Section: Discussionmentioning

confidence: 85%

Relation between blood flow and tissue blood oxygenation in human fingertip skin

Ikawa

Karita

2015

Microvascular Research

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“…The reason for the difference in R2* values between the 2 groups was related to the imaging principle of the BOLD sequence. The BOLD signal in skeletal muscle tissues depends on the ratio between oxyhemoglobin and deoxyhemoglobin in small muscle vessels and can reflect the microcirculation of the tissues ( 24 ). Specifically, deoxyhemoglobin is paramagnetic, which leads to heterogeneity of the local magnetic field and can shorten the T2* value of tissues ( 20 ), while R2* and T2* have a reciprocal relationship with each other ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Functional magnetic resonance imaging reveals dysfunction of the paraspinal muscles in patients with chronic low back pain: a cross-sectional study

Chen¹,

Huang²,

Zhang³

et al. 2023

Quant Imaging Med Surg

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Background: Patients with chronic low back pain (CLBP) undergo structural changes of the paraspinal muscles; however, it is unclear if functional changes also occur. This study aimed to examine the metabolic and perfusion function changes in the paraspinal muscles of patients with CLBP as indirectly reflected by blood oxygen level-dependent (BOLD) imaging and T2 mapping.Methods: All participants were consecutively enrolled at our local hospital from December 2019 to November 2020. Patients were diagnosed with CLBP in the outpatient clinic, and asymptomatic participants were considered to be those with no CLBP or other diseases. This study was not registered on a clinical trial platform. Participants underwent BOLD imaging and T2 mapping scans at the L4-S1 disc level. The effective transverse relaxation rate (R2* values) and transverse relaxation time (T2 values) of the paraspinal muscles were measured on the central plane of the L4/5 and L5/S1 intervertebral discs. Finally, the independent samples t-test was used to assess the differences in R2* and T2 values between the 2 groups, while Pearson correlation analysis was used to determine their correlation with age.Results: A total of 60 patients with CLBP and 20 asymptomatic participants were enrolled. The paraspinal muscles of the CLBP group had higher total R2* values [46.7±2.9 vs.

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Correlation of skeletal muscle blood oxygenation level‐dependent MRI and skin laser doppler flowmetry in patients with systemic sclerosis

Abstract: Skeletal muscle BOLD T2* signal in SSc patients is closely correlated with changes of microperfusion as detected by LDF.

Cited by 11 publications

References 21 publications

Comparison of regional skeletal muscle tissue oxygenation in college athletes and sedentary control subjects using quantitative BOLD MR imaging

Comparison of regional skeletal muscle tissue oxygenation in college athletes and sedentary control subjects using quantitative BOLD MR imaging

Relation between blood flow and tissue blood oxygenation in human fingertip skin

Functional magnetic resonance imaging reveals dysfunction of the paraspinal muscles in patients with chronic low back pain: a cross-sectional study

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