Correlation of skin, nasal and inhalation tests with the IgE in the serum, nasal fluid and sputum

Abstract

In the course of developing a planned treatment by hyposensitization, still undergoing clinical trials, a system was devised which might be used in assessing respiratory allergies. The sensitivity of the patient assessed by skin, topical nasal instillation and inhalation tests was related to the appearance of IgE-staining cells in the nasal secretion and sputum after a successful challenge test, and the correlation of IgE in the serum and nasal fluid.The presence of increased eosinophil cell content and the demonstration of IgE in the nasal secretion or sputum associated with a positive clinical response after the challenge test, confirmed the sensitivity to a particular allergen. Raised levels of IgE in the serum of allergic patients corresponded to the size of the skin test reactions but not necessarily to the quantity of IgE appearing in the nasal fluid or sputum.

Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation

“…IgE antibodies have a central role in allergic disease, with elevated levels of both total and allergen-specific IgE in serum of atopic patients [1,2]. This is frequently paralleled by high levels of total and allergen-specific IgG4 [3].…”

A Trial of House Dust Mite adsorbed on Tyrosine in General Practice

“…Furthermore, only patients who were demonstrated to have positive skin reactions to solutions of D. pteronyssinus were included. The correlation, however, between skin test reactions and other tests of hypersensitivity is not complete (Gronemeyer and Fuchs, 1959; Houri et al 1972; Aas, 1970). However, no other skin tests were undertaken in the majority of these patients, who may therefore have multiple sensitivities.…”

Prevalence of antigen‐specific immunoglobulin E on mucosal brush biopsy of the inferior turbinates in patients with nonallergic rhinitis

“…It has previously been shown that antigen‐specific IgE can be produced in the sinonasal mucosa of people with seasonal and perennial allergic rhinitis (AR), and increases rapidly in the epithelium and nasal secretions of people with AR who are challenged with an antigen to which they are sensitized . It has also been demonstrated that locally‐produced IgE can be present in nasal secretions even though skin testing and in vitro testing are negative. Based on these findings, it has been suggested that people diagnosed with idiopathic NAR may actually have allergic sensitization exclusively in the local region where symptoms are most active.…”