Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease

Kim, Eun Ja; Baek, Joon Hyun; Shin, Dong Jin; Park, Hyeon-Mi; Lee, Yeong-Bae; Park, Kee-Hyung; Shin, Dong Hoon; Noh, Young; Sung, Young Hee

doi:10.14802/jmd.14003

Cited by 17 publications

(16 citation statements)

References 30 publications

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“…A recent study that included early, untreated patients with PD failed to find any difference in changes in sleepiness and sleep structure using polysomnography between the PD and control group, with the exception of significantly increased rapid eye movement sleep without atonia observed in PD group, which cannot be compared to our results because we did not include control group in our study (31). Contrary to the present study results, the recent study be Kim et al (32), which assessed the relationship between sleep disturbances and cognitive impairment using PDSS, PSQI, ESS, interstimulus intervals, MMSE and MoCA, failed to show a correlation of MoCA/MMSE with PSQI or ESS, but did find a significant correlation of MoCA/MMSE with sub-items of PDSS, PD-related sleep disturbances.…”

Section: Discussioncontrasting

confidence: 99%

Sleep Quality and Cognitive Impairment in Patients with Parkinson’s Disease in Iran

Sahebzadeh¹,

Baf²,

Homam³

2016

tnd

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Materials and Methods:In this analytical cross-sectional study, 120 patients with PD were selected from 22-Bahman and 17-Shahrivar hospitals. Demographic information was recorded on a form and Parkinson's severity was determined using the Hoehn and Yahr scale (HY). Pittsburgh Sleep Quality Index (PSQI) and Epworth sleepiness scale (ESS) were used for the assessment of sleep quality and excessive daytime sleepiness, respectively. Cognitive status was assessed using the Montreal Cognitive Assessment questionnaire. Results:The mean age of patients with PD was 65.9±11.7 years, and 67.5% were men. Cognitive impairment was found in 113 (94.2%) patients, poor sleep quality in 87 (72.5%), and excessive daytime sleepiness in 27 (22.5%) patients. The mean PSQI and ESS scores were 9.03±4.70 and 7.38±3.73, respectively. There was a significant association between cognitive status and sleep quality, as well as daytime sleepiness (independent sample t-test, p<0.0001 for both). Conclusion:There is a significant association between cognitive impairment and poor sleep quality as well as excessive daytime sleepiness. Bulgular: PH hastalarının yaş ortalaması 65,9±11,7 yıl idi ve bunların %67,5'i erkekti. Hastaların 27'sinde (%22,5) kognitif bozukluk, 87'sinde (%72,5) gündüz aşırı uykululuk ve 113'ünde (%94,2) kötü uyku kalitesi bulundu. PUKİ ortalama ve ESS skorları sırasıyla 9,03±4,70 ve 3,73±7,38 idi. Kognitif durum ve uyku kalitesi yanı sıra gündüz uykululuk arasında bir anlamlı ilişki saptandı (p<0,0001). Sonuç:Kognitif bozukluk ve kötü uyku kalitesi yanı sıra gündüz aşırı uykululuk arasında anlamlı bir ilişki vardır.

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Section: Discussioncontrasting

confidence: 99%

Sleep Quality and Cognitive Impairment in Patients with Parkinson’s Disease in Iran

Sahebzadeh¹,

Baf²,

Homam³

2016

tnd

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“…Moreover, it is difficult to conclude a specifically circadian role in cognition based only on actigraphic rest-activity data, which reflect not only circadian function, but also sleep and sleep-wake timing. Given the known relation between sleep and cognitive impairment in PD, 11,12 Whitehead et al's 10 finding may not, in fact, indicate an independent circadian association with cognition.…”

Section: Abstract: Backgroundmentioning

confidence: 95%

Circadian Rest‐Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep

Gilbert

et al. 2018

Movement Disord Clin Pract

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Background Cognitive impairment is a common and debilitating symptom of Parkinson's disease (PD), and its etiology is likely multifactorial. One candidate mechanism is circadian disruption. Although there is evidence of circadian abnormalities in PD, no studies have directly assessed their association with cognitive impairment. Objectives Investigate whether circadian rest‐activity rhythm is associated with cognitive function in PD independently of sleep. Methods Thirty‐five participants with PD wore wrist actigraph monitors and completed sleep diaries for 7 to 10 days, then underwent neuropsychological testing. Rest‐activity rhythm was characterized using nonparametric circadian rhythm analysis of actigraphy data. Objective sleep parameters were also estimated using actigraphy data. Hierarchical regression models assessed the independent contributions of sleep and rest‐activity rhythm to cognitive performance. Results Less stable day‐to‐day rest‐activity rhythm was associated with poorer executive, visuospatial, and psychomotor functioning, but not with memory. Hierarchical regressions showed that interdaily stability's contribution to cognitive performance was independent of sleep's contributions. Whereas sleep contributed to executive function, but not psychomotor or visuospatial performance, rest‐activity rhythm stability significantly contributed to variance in all three of these domains, uniquely accounting for 14.4% to 17.6% of their performance variance. Conclusions Our findings indicate that circadian rest‐activity rhythm is associated with cognitive impairment independently of sleep. This suggests the possible utility of rest‐activity rhythm as a biomarker for circadian function in PD. Future research should explore interventions to stabilize behavioral rhythms in order to strengthen circadian function, which, in turn, may reduce cognitive impairment in PD.

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“…Sebuah penelitian menyatakan bahwa terdapat korelasi positif antara kejadian insomnia dengan gangguan fungsi kognitif pada penderita Parkinson (Kim, 2014). Penelitian lain juga menambahkan bahwa kekurangan tidur akan memberikan efek pada fungsi kognitif yang disebabkan kurangnya suplai oksigen dan nutrisi kedalam jaringan otak (Missildine, 2008).…”

Section: Pendahuluanunclassified

Insomnia is not a Risk Factor for Impaired Cognitive Function in Elderly

Sincihu

Kurniawati

2018

Qanun Medika

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Elderly are often considered as a burden because of their physical limitations. The reduced cognitive function is one of the important causes for this physical limitation. Quality of sleep used to be associated with changes in cognitive function. A comparative analytic research to assess insomnia as a risk factor for the incidence of cognitive function impairment in the elderly. A case-control study in elderly community at the nursing home St.Yosef, Surabaya. Fifty respondents were taken by consecutive sampling and meeting the inclusion criteria. This study also excluded people with depression, schizophrenia, and users of psychotropic drugs. Eighty four percent of respondents have impaired cognitive function. Not much difference in percentage of insomnia disturbance in control group (37,5%) and case group (35,8%). Fisher's Exact Test show Sig.0,609 and OR=0.926 on CI [(0,194),(4,425)]. It was concluded that insomnia alone was not a risk factor for impaired cognitive modalities. Elderly exposed to sleep disorders have the same tendency to suffer cognitive impairment with unexposed. Keywords: Elderly, Impaired cognitive function, Insomnia Correspondence to : tmnitakurniawati@gmail.com, yudhiakuari@ukwms.ac.id ABSTRAK Seringkali lansia dianggap sebagai beban karena berbagai keterbatasan fisik yang mereka derita. Penurunan fungsi kognitif menjadi salah satu penyebab kondisi tersebut. Kualitas tidur diduga berhubungan dengan perubahan fungsi kognitif. Penelitian analitik komparasi untuk menilai insomnia sebagai faktor resiko kejadian gangguan fungsi kognitif pada lansia. Penelitian ini merupakan studi kasus kontrol pada komunitas lansia di Panti Werdha St,Yosef, Surabaya. Sampel diambil dengan cara consecutive sampling. Ditemukan 50 responden yang sesuai kriteria inklusi. Penelitian ini mengekslusi penderita depresi, dan skizofrenia, serta pengguna obat psikotropika. Ditemukan 84% responden dengan gangguan fungsi kognitif. Tidak banyak perbedaan persentase gangguan insomnia pada kelompok kontrol (37,5%) maupun kelompok kasus (35,8%). Hasil Fisher's Exact Test menunjukan Sig.0,609 dan nilai OR=0,926 pada CI [(0,194), (4,425)]. Insomnia secara tunggal bukan faktor resiko terjadinya gangguan modalitas kognitif. Lansia yang terpapar gangguan tidur mempunyai kecenderungan yang sama untuk menderita gangguan kognitif bila dibandingkan dengan mereka yang tidak terpapar. Kata kunci: Gangguan fungsi kognitif, Insomnia, Lansia Korespondensi :

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Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease

Cited by 17 publications

References 30 publications

Sleep Quality and Cognitive Impairment in Patients with Parkinson’s Disease in Iran

Sleep Quality and Cognitive Impairment in Patients with Parkinson’s Disease in Iran

Circadian Rest‐Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep

Insomnia is not a Risk Factor for Impaired Cognitive Function in Elderly

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