Correlation of social cognition and neurocognition on psychotic outcome: a naturalistic follow-up study of subjects with attenuated psychosis syndrome

Abstract

Neurocognitive decline has been observed in patients with psychosis as well as attenuated psychosis syndrome (APS). We tested the hypothesis that APS increases dependence on neurocognition during the interpretation of others’ mental states and that a combination index of Theory of Mind (ToM) and neurocognition improves the predictive accuracy of psychosis conversion. A sample of 83 APS individuals and 90 healthy controls (HC) were assessed by comprehensive cognitive tests. The cohort also completed a one-year follow-up. In the APS group, ToM was associated with an apparent increase in neurocognition, but this trend was not evident in the HC group. Using the new index of combined neurocognition and ToM scores, the sensitivity for predicting psychosis-proneness was 75% and the specificity was 69%. Our data suggest that the correlations between ToM function and neurocognition in APS subjects were stronger than those in healthy controls. A composite index of neurocognition and ToM could improve the predictive validity of a future conversion to psychosis.

Clinical Validity ofDSM-5Attenuated Psychosis Syndrome

“…Neurocognitive 47,50,51 , social cognitive 50 and metacognitive 47 dysfunction, although not diagnostically required, are also frequent, while neurobiological research into DSM-5-APS/APSS is too limited to draw reliable conclusions.…”

Prediction of psychosis in prodrome: development and validation of a simple, personalized risk calculator

“…Clinicians in particular recognize the importance of discerning accurately how much ‘real’ risk is faced by those CHRs, because this information may affect treatment and monitoring strategies. Extensive research suggests that there are differences in baseline clinical characteristics, such as greater severity of thought disorder symptoms (DeVylder et al ., 2014; Perkins et al ., 2015), functional decline (Thompson et al ., 2011; Li et al ., 2017), and deficits in neurocognition (Seidman et al ., 2010, 2016) and social cognition (Zhang et al ., 2016, 2018 a ), between CHR individuals who converted to psychosis and those who did not. Existing literature concerning these predictors offers the hope of developing multivariable models (Michel et al ., 2014; Cornblatt et al ., 2015) with a wide set of clinical factors to improve the power of prediction.…”

Comparing the Self-Reported Personality Disorder Traits and Childhood Traumatic Experiences Between Patients With Schizophrenia Vs. Major Depressive Disorder

“…Second, PD traits and CTE were assessed using a self-report, retrospective measure. Self-report measures assume reliable reporting, which may be a concern in our patient populations, especially in patients with SZ, who are more likely to have cognitive impairment ( 32 – 34 ). Furthermore, the data are cross-sectional, cohort studies are more valuable for establishing a temporal link between CTE, PD traits, and later psychiatric disorders.…”