The paper assessed the impact of the heat treatment of spruce wood, the (radial and tangential) side of the specimens exposed to fire, and the type of material (prism—higher density, floor—lower density) on the combustion process and the rate of fire spread. Five groups of specimens were used—untreated spruce wood specimens, two groups of heat-treated spruce wood specimens from the prism (higher density specimens), and two groups of heat-treated spruce wood specimens from the floor (lower density specimens). In one group, the flame was applied to the radial side, and in the other group to the tangential side of the specimens. The effect on the combustion process was assessed based on the parameters of mass loss and mass loss rate over time. The effect on the rate of fire spread across the specimens was assessed by the parameter fire spread rate. These parameters were determined using a simple test method where the specimens were exposed to a direct flame at an angle of 45°. To complement the results and to assess the processes involved, the temperatures at the specimen surfaces were also measured during the experiment. The main achieved results of the study are the findings on how the heat treatment, the density, and the side of the wood along which the fire spreads affect the burning process of the wood. The results indicated a significant effect of the density of the spruce thermowood on its combustion process. The higher density radial specimens exhibited a higher mass loss rate, and the overall average mass loss of the higher density samples was 27% of the original mass higher than that of the lower density samples. Additionally, the results suggested that the heat treatment of lower-density spruce wood (floor) does not significantly affect the mass loss and the mass loss rate. The difference in the overall average mass loss of the thermowood of floor and untreated wood samples was less than 2%, which is statistically insignificant. It was also found that for thermowood, fire will spread faster on the tangential side, where the fire spread rate is 29% higher compared with the radial side (for the floor samples). Based on the findings of other authors in a similar field, the results confirm that heat-treated spruce wood is more easily ignitable than untreated wood, which was proven by the spontaneous combustion of most of the thermowood samples during the experiment compared with the untreated wood samples.