Correlation of Subjective Symptoms in Patients with Benign Prostatic Hyperplasia and Erectile Dysfunction

Kardasevic, Amel; Miličević, Snježana

doi:10.5455/medarh.2017.71.32-36

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Several studies have shown that DM-2 is associated with a significantly low serum total PSA level than in non-diabetic individuals due to lower androgen levels found in diabetic men ( 2 ). Likewise, another study by Muller et al ( 3 , 4 ) reported that men with very high level of hemoglobin A1c (like in our patient) had 29% lower serum levels of PSA at later stages of diabetes. There have been additional reports on the decrease in testosterone level in men with DM-2 due to hypogonadism evident with low PSA values ( 4 ).…”

Section: Discussionsupporting

confidence: 82%

Diabetes mellitus-induced lower urinary tract symptoms and hepatic steatosis in an older male

Opara

2022

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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Summary Diabetes mellitus type 2 (DM-2) is one of the important causes of low-grade chronic inflammation (meta inflammation) seen in almost all tissues in the body. Other possible mechanisms involved in the development of lower urinary tract symptoms (LUTS) with DM-2 are the hypertonicity of the peripheral sympathetic nerves and hyperinsulinemia effects on the autonomous nervous system activity. These further suggests that abnormalities in glucose homeostasis influence the hyperproliferation of the prostate cells resulting in benign prostatic hyperplasia (BPH). Similarly, hepatic steatosis, a form of non-alcoholic fatty liver disease (NAFLD) prevalence among patients with DM-2, is as high as 75%. NAFLD has no symptoms in most diabetic patients. In this study, we present a case of a 64-year-old Black male who had worsening urinary urgency and hesitancy for 4 months, with increasing abdominal girth. Patient was found to have symptoms, diagnostic studies, and physical exam findings indicative of BPH and fatty liver disease. He was treated with hepato-protective medications, tighter control of his blood glucose levels, and blood pressure meds for 13 months. Upon follow-up, most of his symptoms were resolved. Timeline of BPH resolution and decrease in liver size following treatment suggest that DM-2 has a strong correlation with the development of BPH and fatty liver disease in most patients living with diabetes. Learning points Men with type 2 diabetes mellitus (DM-2) tend to have significantly lower serum PSA level, lower testosterone levels, and larger prostate volume compared to non-diabetic male patients. Patients with DM-2 have higher prevalence of hepatic steatosis, liver cirrhosis, and end-stage liver failure. The role of metformin in reducing hepatic steatosis as stated by several studies is yet to be validated as our patient has been on metformin for 22 years for the management of DM-2 with fatty liver disease.

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Section: Discussionsupporting

confidence: 82%

Diabetes mellitus-induced lower urinary tract symptoms and hepatic steatosis in an older male

Opara

2022

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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“…Finally, prostate hyperplasia was found in every third ED patient undergoing CTA. The connection between prostate hyperplasia and ED is quite complex and it was previously reported that 70% of men with prostate hyperplasia have an associated ED [32][33][34]. Thus, our imaging study confirms a close interrelation of prostate hyperplasia and ED.…”

Section: Original Articlesupporting

confidence: 86%

Incidental findings during computed tomographic angiography diagnostic work-up in patients with arteriogenic erectile dysfunction

Schönhofen¹,

Mohan

Schumacher

et al. 2019

Swiss Med Wkly

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AIM: To analyse the incidental findings during computed tomographic angiography (CTA) diagnostic work-up in patients with arteriogenic erectile dysfunction (ED). PATIENTS AND METHODS:The medical records of all patients with suspected arteriogenic ED were entered into a database. Risk factors and underlying comorbidities were also collected. Pathological CTA findings were extracted from the CT readings and entered into the database. Incidental findings on CTA were classified as those requiring immediate medical treatment, requiring deferred medical treatment or of no clinical importance. RESULTS: A total of 200 patients underwent CTA for suspected arteriogenic ED. Mean patient age was 59.6 ± 11.7 years. Of these, 181 patients (90.5%) had obstructions of erection-related arteries. In 168 patients (84.0%), CTA showed multiple incidental pathological findings. Eightyfive of 200 patients (42.5%) exhibited incidental findings requiring immediate further medical workup and/or treatment: coronary artery calcification was diagnosed in 75/ 200 (37.5%), aorto-iliac aneurysms in 8/200 (4%) of patients and incidentally detected embolism in 1/200 patient. Pancreatic and liver tumours were less frequent (incidence 1.5% and 1%, respectively). Incidental findings requiring deferred medical workup and/or treatment were detected in 175/200 patients (87.5%). The findings with the highest prevalence were liver steatosis followed by colon diverticulosis and prostate hyperplasia. Findings of little to no clinical importance were reported in 117 (58.5%) patients. These included uncomplicated renal cysts, spinal degeneration and renal vascular anomalies. Almost every second patient presenting with ED had an incidental finding which required immediate treatment. CONCLUSIONS: Incidental findings not directly related to ED were common among patients undergoing CTA scans for suspected arterial obstructions. Coronary artery calcification was the leading finding requiring further medical workup and/or treatment. Thus, the benefit of CTA investigations extends beyond the anatomic description of arterial obstructions of erection-related arteries.

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“…Heterogeneity across studies was high (I 2 = 90%, P < 0.001). Six studies (17,19,27,(36)(37)(38) reported scores of assessment tools for sexual dysfunction as a measurement of sexual dysfunction in participants with different severities of LUTS. The result suggested that men with higher severity of LUTS had lower scores of assessment tools for sexual dysfunction compared with those with lower severity (WMD = −5.49, 95%CI: −7.25 to −3.27, P < 0.001, Figure 3).…”

Section: Overall Assessment Of Sexual Dysfunctionmentioning

confidence: 99%

“…In those studies which reported scores of assessment tools for sexual dysfunction, 4 assessment tools had been used to measure sexual dysfunction. Five-item International Index of Erectile Function (IIEF-5), IIEF, Brief Male Sexual Function Inventory (BMSFI) and Epstein Inventory were used to assess sexual dysfunction in two studies (17,37), two studies (19,27), one study (36) and one study (38), respectively. The results showed that participants with higher severity of LUTS had lower scores of the assessment tools than participants with lower severity of LUTS in all groups (IIEF-5 group: WMD = −6.42, 95%CI: −8.26 to −4.58, P < 0.001, I 2 = 92%; IIEF group: WMD = −5.80, 95%CI: −9.70 to −1.91, P = 0.003, I 2 = 37%; BMSFI group: WMD = −2.60, 95%CI: −3.10 to −2.10, P < 0.001; Epstein inventory group: WMD = −5.98, 95%CI: −6.75 to −5.21, P < 0.001).…”

Section: Subgroup Analysismentioning

confidence: 99%

Lower Urinary Tract Symptoms and Sexual Dysfunction in Male: A Systematic Review and Meta-Analysis

et al. 2021

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Background: An association between lower urinary tract symptoms (LUTS) and risk of sexual dysfunction in male remains controversial in recent decades.Materials and Methods: PubMed and Web of Science were searched up to October 28, 2020, for articles reporting the prevalence of sexual dysfunction in men with LUTS. The main outcomes were results from sexual dysfunction assessments. Pooled odds ratio (OR) and weighted mean difference (WMD) with 95% confidence interval (CI) were calculated. The quality assessment of the included studies was performed by using The Newcastle-Ottawa Scale (NOS) or JBI Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI).Results: A total of 24 full-manuscript papers met the inclusion criteria. The pooled OR for 21 studies suggested that patients with severer LUTS had a higher risk of sexual dysfunction (OR = 3.31, 95% CI: 2.43 to 4.49, p < 0.001, I2 = 90%). A significant decrease in scores of assessment tools for sexual dysfunction was observed in the patients with higher severity of LUTS compared with those patients with lower severity (WMD = −5.49, 95%CI: −7.25 to −3.27, P < 0.001, I2 = 96%). Similar outcomes were also found in subgroup analyses. In a detailed analysis of specific sexual function domains, the severity of LUTS was associated with erectile dysfunction, intercourse satisfaction, and overall satisfaction, except for sexual desire.Conclusion: The study demonstrates an association between exposure of lower urinary tract symptoms and risk of sexual dysfunction in male. Assessment of sexual function is necessary for patients with lower urinary tract symptoms.Systematic Review Registration:http://www.crd.york.ac.uk/prospero, identifier: CRD42020208747.

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Correlation of Subjective Symptoms in Patients with Benign Prostatic Hyperplasia and Erectile Dysfunction

Cited by 7 publications

References 26 publications

Diabetes mellitus-induced lower urinary tract symptoms and hepatic steatosis in an older male

Diabetes mellitus-induced lower urinary tract symptoms and hepatic steatosis in an older male

Incidental findings during computed tomographic angiography diagnostic work-up in patients with arteriogenic erectile dysfunction

Lower Urinary Tract Symptoms and Sexual Dysfunction in Male: A Systematic Review and Meta-Analysis

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