Correlation of TET‐2 Levels with Disease Evaluation in AMI Patients

Abstract

Objective. To investigate the expression levels of Ten-Eleven Translocation-2 (TET-2) in patients with acute myocardial infarction (AMI) and correlations of TET-2 levels with disease severity. Methods. A total of 150 patients with confirmed AMI were included in this study. According to the number of coronary artery lesions, the patients were divided into a single lesion group, two lesion group, and three lesion group. According to the Gensini scores, these patients were also assigned into three groups: the low-risk group, middle-risk group, and high-risk group. 150 patients without AMI confirmed by coronary angiography were included in the control group in the same period. TET-2 and cardiac troponin T (cTNT) levels were detected by ELISA analysis and compared among different groups. Pearson’s correlation analysis was used to evaluate the correlations of TET-2 levels and cTNT levels/Gensini scores. The levels of TET-2 in AMI patients increased remarkably with the increase of disease severity. Patients in the single lesion group or low-risk group had the lowest levels of TET-2. Pearson correlation analysis indicated that TET-2 levels were positively associated with cTNT levels and Gensini scores, respectively (all P < 0.001 ). Conclusion. The levels of TET-2 were upregulated in AMI patients and positively correlated with cTNT levels or Gensini scores, suggesting that the examination of TET-2 expression levels could be exploited for predicting the disease severity.

The Role of Selected Epigenetic Pathways in Cardiovascular Diseases as a Potential Therapeutic Target

“…It is currently unknown whether extranuclear Tet compartmentalization occurs in the heart of diabetic patients and whether this phenomenon plays a role in this context. In contrast, a study from 2022 with n = 150 patients with AMI [ 148 ] showed a significant increase in Tet-2 levels, positive correlation of Tet2 with infarct size, cTNT levels and Gensini score (all, p < 0.001). The researchers included the representation of people with CV-risk factors, including diabetes, in the control and study groups, noting the lowest Tet2 levels in the group with the lowest CV risk.…”