Correlation of tetradecylmaltoside induced increases in nasal peptide drug delivery with morphological changes in nasal epithelial cells

Arnold, John J.; Ahsan, Fakhrul; Meezan, Elias; Pillion, Dennis J.

doi:10.1002/jps.20123

Cited by 38 publications

(29 citation statements)

References 22 publications

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“…This holds particularly true if the latter are intended to eventually enhance drug absorption. For example, Vllasaliu et al reported that alkyglycoside surfactant shows a significant toxicity in Calu-3 cells [41], probably due to the fact that alkylglycosides open the tight junctions in bronchial epithelium, as observed by the increased paracellular movement of mannitol [42,43]. In contrast, when Calu-3 cells were incubated with alkylglycosides in medium containing serum or under ALI conditions, cytotoxicity was reduced compared to submerged conditions.…”

Section: In Vitro Models Based On Cells and Reconstructed Tissuesmentioning

confidence: 88%

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Hittinger

Juntke

Kletting

et al. 2015

Advanced Drug Delivery Reviews

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Section: In Vitro Models Based On Cells and Reconstructed Tissuesmentioning

confidence: 88%

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Hittinger

Juntke

Kletting

et al. 2015

Advanced Drug Delivery Reviews

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“…These agents, which were initially developed at the University of Alabama at Birmingham, are a group of medium chain alkylglycosides including dodecylmaltoside and tetradecylmaltoside. Enhanced nasal bioavailabilities of calcitonin, insulin, and human growth hormone were demonstrated in rats (35), and the enabling excipients are said to be well tolerated (36). In a study in healthy human subjects, nasal bioavailability of calcitonin was improved from 6.6% with a control formulation to 35.9% with dodecylmaltoside (37).…”

Section: Products In Developmentmentioning

confidence: 99%

Absorption Enhancers: Applications and Advances

Aungst¹

2011

AAPS J

262

119

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Abstract. Absorption enhancers are functional excipients included in formulations to improve the absorption of a pharmacologically active drug. The term absorption enhancer usually refers to an agent whose function is to increase absorption by enhancing membrane permeation, rather than increasing solubility, so such agents are sometimes more specifically termed permeation enhancers. Absorption enhancers have been investigated for at least two decades, particularly in efforts to develop non-injection formulations for peptides, proteins, and other pharmacologically active compounds that have poor membrane permeability. While at least one product utilizing an absorption enhancer for transdermal use has reached the market, quite a few more appear to be at the threshold of becoming products, and these include oral and transmucosal applications. This paper will review some of the most advanced absorption enhancers currently in development and the formulation technologies employed that have led to their success. In addition, a more basic review of the barriers to absorption and the mechanisms by which those barriers can be surmounted is presented. Factors influencing the success of absorption-enhancing formulations are discussed. If ultimately successful, the products now in development should offer noninjection alternatives for several peptide or protein drugs currently only administered by injection. The introduction of new absorption enhancers as accepted pharmaceutical excipients, and the development of formulation technologies that afford the greatest benefit/risk ratio for their use, may create opportunities to apply these enabling technologies more broadly to existing drugs with non-optimal delivery properties.

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“…Achieving pain control in acute pain situations such as battlefield injury, EMS first responders, emergency department cases and breakthrough cancer pain has quite often proved challenging [1][2][3]. Although opioid medications are effective at acute pain relief, current delivery methods can fail or prove inadequate in many circumstances.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Nasal Hydromorphone with High Bioavailability for Rapid Onset and Non-Dissociative Acute Pain Control: A Feasibility Study

Cunningham¹,

Et²

2018

J Bioequiv Availab

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Correlation of tetradecylmaltoside induced increases in nasal peptide drug delivery with morphological changes in nasal epithelial cells

Cited by 38 publications

References 22 publications

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Absorption Enhancers: Applications and Advances

Non-Invasive Nasal Hydromorphone with High Bioavailability for Rapid Onset and Non-Dissociative Acute Pain Control: A Feasibility Study

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