Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients

Owczarek, Witold; Słowińska, Monika; Walecka, Irena; Ciążyńska, Magdalena; Nowicka, Dorota; Walczak, Leszek; Paluchowska, Elwira

doi:10.3390/life11020146

Cited by 9 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PDT has been reported to be effective in the inactivation of mammalian viruses, such as human immunodeficiency virus (HIV), human papillomavirus (HPV), hepatitis A, B, and C viruses, herpes viruses, human parvovirus B19, human cytomegalovirus, enteroviruses, and adenoviruses [145][146][147]. PDT started to be intensively researched in the pandemic context as an alternative or complementary treatment strategy to target SARS-CoV-2 [34,[148][149][150][151][152].…”

Section: Non-malignant Diseasesmentioning

confidence: 99%

Photodynamic Therapy—An Up-to-Date Review

2021

View full text Add to dashboard Cite

The healing power of light has attracted interest for thousands of years. Scientific discoveries and technological advancements in the field have eventually led to the emergence of photodynamic therapy, which soon became a promising approach in treating a broad range of diseases. Based on the interaction between light, molecular oxygen, and various photosensitizers, photodynamic therapy represents a non-invasive, non-toxic, repeatable procedure for tumor treatment, wound healing, and pathogens inactivation. However, classic photosensitizing compounds impose limitations on their clinical applications. Aiming to overcome these drawbacks, nanotechnology came as a solution for improving targeting efficiency, release control, and solubility of traditional photosensitizers. This paper proposes a comprehensive path, starting with the photodynamic therapy mechanism, evolution over the years, integration of nanotechnology, and ending with a detailed review of the most important applications of this therapeutic approach.

show abstract

Section: Non-malignant Diseasesmentioning

confidence: 99%

Photodynamic Therapy—An Up-to-Date Review

2021

View full text Add to dashboard Cite

show abstract

“…PDT has been revealed to be effective in the inactivation of mammalian viruses like hepatitis A, B, and C viruses, human papillomavirus (HPV), human immunodeficiency virus (HIV), herpes viruses, human parvovirus B19, human cytomegalovirus, adenoviruses, and enteroviruses [96][97][98]. PDT is widely used in pandemic research as an alternative or complementary therapy approach to target SARS-CoV-2 [99,100].…”

Section: Infectionmentioning

confidence: 99%

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

et al. 2022

View full text Add to dashboard Cite

Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between ROS production and removal. A little raise of ROS results in cell proliferation enhancement, survival, and soft immune responses, while a high level of ROS could lead to cellular damage consequently protein, nucleic acid, and lipid damages and finally cell death. ROS play an important role in various pathological circumstances. On the contrary, ROS can show selective toxicity which is used against cancer cells and pathogens. Photodynamic therapy (PDT) is based on three important components including a photosensitizer (PS), oxygen, and light. Upon excitation of the PS at a specific wavelength, the PDT process begins which leads to ROS generation. ROS produced during PDT could induce two different pathways. If PDT produces control and low ROS, it can lead to cell proliferation and differentiation. However, excess production of ROS by PDT causes cellular photo damage which is the main mechanism used in cancer treatment. This review summarizes the functions of ROS in living systems and describes role of PDT in production of controllable ROS and finally a special focus on current ROS-generating therapeutic protocols for regeneration and wound healing.

show abstract

“…Successful treatment can still be challenging. Traditional forms of treatment for condyloma acuminata that are effective at removing wart tissue including topical approaches, carbon dioxide laser (CO 2 laser), cryotherapy, or electrosurgery [55], or medical treatment with topical agents (imiquimod, podofilox, podophyllin, trichloroacetic acid, sinecatechins ointment) [56,57].…”

Section: Pt For Viral Stismentioning

confidence: 99%

Phototherapy-Based Treatment for Sexually Transmitted Infections—Shining Light into Unexplored Territory

Hamblin

Rauger²,

Boyer

et al. 2022

Venereology

View full text Add to dashboard Cite

New therapeutic strategies are urgently needed to overcome drawbacks in the treatment of some infections, particularly sexually transmitted infections (STI). STIs are easily spread by the transmission of various bacteria, viruses, and parasites with some of the infections being incurable or even lethal, leading to a serious impact on reproductive health worldwide. Phototherapy (PT) is a major therapeutic approach based on the controlled administration of light in the visible, near infrared, or UV spectrum, with or without the application of an external photosensitizer. Despite the fact that PT has not been explored to its full potential in the control of STIs, it has already demonstrated good clinical response rates and lower recurrence rates in genital infections. For instance, increasing evidence has demonstrated that 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) is effective in the treatment of condyloma acuminatum (CA), by eliminating the causative latent human papillomavirus (HPV) infection, and also in the antiviral treatment of recurrent genital herpes simplex virus (HSV) infections. The clinical application of PDT is a new treatment for oral fungal infection caused by Candida albicans in adult acquired immune deficiency syndrome (AIDS) patients, with human immunodeficiency virus (HIV), and could also be used for genital fungal infections. Another antimicrobial PT strategy, water-filtered infrared A combined with visible light irradiation, has been shown to be effective against genital Chlamydia trachomatis bacterial infection, and an optical nano-genosensor has been designed for the diagnosis of trichomoniasis, a parasitic Trichomonas vaginalis infection. This review aims to summarize the published evidence for the effectiveness of PT in the treatment of STIs, and for the suppression of STI-related pathogens of various types.

show abstract

Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients

Cited by 9 publications

References 24 publications

Photodynamic Therapy—An Up-to-Date Review

Photodynamic Therapy—An Up-to-Date Review

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

Phototherapy-Based Treatment for Sexually Transmitted Infections—Shining Light into Unexplored Territory

Contact Info

Product

Resources

About