Correlation of the Body Mass Index and Calcium Nephrolithiasis in Adult Population

Miličević, Snježana; Bijelic, Radojka; Krivokuca, Vladimir; Bojić, Mirjana; Popović-Pejičić, Snježana; Bojanic, Nebojsa

doi:10.5455/medarh.2013.67.423-427

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Our research demonstrates that the average BMI of patients with bilateral kidney stones (26.23 ± 3.53kg/m 2 ) is signi cantly higher than that of patients with unilateral kidney stones (25.82 ± 3.52kg/m 2 ). This is consistent with reports written by Milicevic, S et al and Scales CD Jr et al 1,7 . That is, obesity, overweight, and kidney stones are related, and as BMI increases, urinary calcium and uric acid excretion increases, and the incidence and recurrence rate of urolithiasis are also rising.…”

Section: Discussionsupporting

confidence: 93%

“…In recent years, an increasing number of studies have illustrated that chronic diseases such as metabolic syndrome (MetS), hypertension, diabetes mellitus (DM), obesity, gout, and chronic kidney disease are signi cantly related to kidney stones' occurrence and development [6][7][8][9][10] . Shimizu, T et al reported that hyperuricemia is the leading cause of gout.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

Yang

Zhi

et al. 2021

Preprint

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To determine the incidence and risk factors of bilateral kidney stones. Utilized the retrospective analysis method on demographic characteristics and clinical data of patients with renal stones in the Second Hospital of Tianjin Medical University. Grouped patients into unilateral and bilateral renal stones according to preoperative imaging and ultrasound examination. Univariate and multivariate analysis methods were used to evaluate the factors that may cause bilateral stones. The study included 7587 patients with kidney stones in total, of whom 4983 had unilateral kidney stones (including 2719 left stones and 2264 right stones), and 2604 had bilateral kidney stones (34.3%). By comparing the unilateral stones group with the bilateral stones group, the univariate analysis demonstrated that weight, body mass index (BMI), history of nephrolithiasis, diabetes mellitus (DM), hypertension, gout, and the maximal stone diameter had statistical significance. Binary logistic regression multivariate analysis demonstrated that BMI, history of nephrolithiasis, diabetes mellitus, hypertension, gout, and the maximal stone diameter were independent risk factors for bilateral urinary stones. This study shows that 34.3% of patients with kidney stones were diagnosed as having bilateral kidney stones; BMI and the maximal stone diameter are positively correlated with the incidence of bilateral kidney stones; Patients with a history of nephrolithiasis, diabetes, hypertension, and gout have a significantly higher risk of having bilateral kidney stones.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

Yang

Zhi

et al. 2021

Preprint

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“…For years overweight and obesity have been considered protective factors for bones and osteoporosis development. Nevertheless, new studies show that obesity, being one of main components of metabolic syndrome, has negative eff ects on bones despite normal values of bone mineral density (BMD) measured by DEXA method, which is considered to be the consequence of increased mechanical pressure on the bone (28,29). Ong et al think that higher BMD is not protective factor for osteoporotic fractures, for signifi cant number of such fractures occurs in obese women due to body habitus or mechanism of injury (30).…”

Section: Overweight and Obesitymentioning

confidence: 99%

Association of Urolithiasis With Osteoporosis in Postmenopausal Women: Risk Predictors for the Disease

Bijelic¹,

Miličević²

2020

QOL

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Urolithiasis and osteoporosis are two significant multifactorial diseases that cause the constant increase in the number of affected persons due to the increased age of population and negative effects of environmental factors, i.e. unhealthy lifestyle. Those affected by urolithiasis have an increased risk for osteoporosis. Association of urolithiasis and osteoporosis in postmenopausal women is still not completely understood, but it is certain that those diseases may cause serious consequences leading to the permanent disability and even death due to osteoporotic hip fractures. This is why those disorders remain very significant social, economic and health problems not only for those affected but for the whole society, due to very high treatment costs. Identification of risk factors for menopausal women aims at decreasing the rate of disease and improving of preventive measures. Since both disorders are preventable, preventive measures should be applied from young age, with identification of risk factors being extremely important for significant decrease of morbidity rate.

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“…“Radiopaque” includes calcium stones (calcium oxalate dihydrate, calcium oxalate monohydrate, calcium phosphate), “poor radiopacity” magnesium ammonium phosphate, apatite and cystine, while “radiolucent” includes urine acid, ammonium urate, xanthine, 2,8-dihydroxyadenine and drug-stones ( 5 ). The sensitivity and specificity of KUB radiography is 44-77% and 80-87% ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation of Parathormone and the Serum Values of Acidum Uricum with Calcium Nephrolithiasis Examined by Three Different Methods of Diagnostics

Miličević¹,

Bijelic²,

Jakovljević³

2015

Acta Inform Med

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Introduction.Urolithiasis is a multifactorial disease. Changes in social and economic living conditions have generated changes in chemical composition of urolith too. Although calcium is a predominant crystalline constituent of kidney stones in 80% of cases, metabolic disorders are not the main reason for their formation. Hyperparathyroidism may be a cause of occurrence of calcium lithiasis, however, the biggest number of its occurrence is not a consequence of elevated values of parathormone. Acid uric has a pervasive presence in all body fluids. The serum level of acid uric is determined by its rate of synthesis, rate of excretion by kidney and gastrointestinal tract, and metabolism.Goal.The goal of our study is to determine a correlation of calcium lithiasis of the upper part of the urinary tract with the parathormone values and the concomitant values of acidum uricum.Material and methods.The study was prospective and included 120 patients with calcium lithiasis of the upper part of urinary tract, divided in three age categories, 20-40 years, 40-60 years and older than 60 years. The diagnosis of calcium lithiasis of the upper part of the urinary tract was made on the basis of urinary tract ultrasonography, and kidney-ureter-bladder radiography (KUB) /intravenous urography (IVU), urine culture and chemical analysis of stone with patients who had a spontaneous emission of stone or following some of the methods for active removal of stone; with some patients non-contrast (NCCT) was carried out too. All patients were subjected to the laboratory analysis of the serum level of acidum uricum and parathormone.Results.With observed 120 patients suffering from calcium urolithiasis, who belonged to adult population, no patient had an elevated value of parathormone, while three patients (2.5%) had the values of acidum uricum higher than the reference values. The average value (for both parameters) was the lowest with the youngest patients and vice versa, and only in the group of 40 to 60 years of age there were patients whose values of the acidum uricum parameter was outside the interval of reference values; the other age groups did not have such values. Based on the analysis of the variance, as a statistical method, it was determined that the average values of acidum uricum in different age groups were statistically significantly different, which is not the case for the parameter parathormone. (p>0,05).Conclusion.The biggest number of nephrolithiasis is not a consequence of elevated values of parathormone. Hyperuricosemia may be present with calcium urolithiasis, without participation in forming kidney stones, most probably as an indirect sign of the existence of the initial insulin resistance and metabolic disease.

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Correlation of the Body Mass Index and Calcium Nephrolithiasis in Adult Population

Cited by 10 publications

References 15 publications

Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

Association of Urolithiasis With Osteoporosis in Postmenopausal Women: Risk Predictors for the Disease

Correlation of Parathormone and the Serum Values of Acidum Uricum with Calcium Nephrolithiasis Examined by Three Different Methods of Diagnostics

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