Correlation of the eluting strengths of solvents in adsorption chromatography with solvatochromic parameters

Luehrs, Dean C.; Chesney, David; Godbole, Kalpana A.

doi:10.1016/0021-9673(92)87184-a

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…The linear solvation energy relationship (LSER) system of the Kamlet and Taft group has the following advantages: it is relatively easy to use, it can be applied to a wide range of problems from electronic spectra to toxicity to fish, the results can be interpreted to give chemical information, and the parameters are not highly correlated (21)(22)(23). In particular, the LSER approach has had considerable success in application to adsorption equilibria (8,24,25). Kamlet et al (8) showed how well the LSER approach could be applied to adsorption on activated carbon.…”

Section: Introductionmentioning

confidence: 99%

Linear Solvation Energy Relationship of the Limiting Partition Coefficient of Organic Solutes between Water and Activated Carbon

Luehrs

Hickey

Nilsen

et al. 1995

Environ. Sci. Technol.

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A linear solvation energy relationship has been found for 353 values of the limiting adsorption coefficients of diverse chemicals: log K = −0.37 + 0.0341Vi − 1.07β + D + 0.65P with R = 0.951, s = 0.51, n = 353, and F = 818.0, where Vi is the intrinsic molar volume; β is a measure of the hydrogen bond acceptor strength of the solute; D is an index parameter for the research group which includes the effects of the different types of carbon used, the temperature, and the length of time allowed for the adsorption equilibrium to be established; and P is an index parameter for the flatness of the molecule. P is defined to be unity if there is an aromatic system in the molecule or if there is a double bond or series of conjugated double bonds with no more that one non-hydrogen atom beyond the double bond and zero otherwise. A slightly better fit is obtained if the two-thirds power of Vi is used as a measure of the surface area in place of the volume term: log K = −1.75 + 0.227V 2/3 − 1.10β + D + 0.60P with R = 0.954, s = 0.49, n = 353, and F = 895.39. This is the first quantitative measure of the effect of the shape of the molecule on its tendency to be adsorbed on activated carbon.

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Section: Introductionmentioning

confidence: 99%

Linear Solvation Energy Relationship of the Limiting Partition Coefficient of Organic Solutes between Water and Activated Carbon

Luehrs

Hickey

Nilsen

et al. 1995

Environ. Sci. Technol.

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“…Selectivity factors for each of the phenylalanine analogs were calculated from the peak maxima and are given in Table 4. From these data it is evident that the mobile phase 18,19 The subscript M is used to differentiate the modifier hydrogen bond donating ability (␣ M ) from the selectivity factor (␣).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the specific intermolecular interactions responsible for chiral selectivity for phenylalanine analogs in subcritical fluid chromatography

Blackwell

Stringham

1999

Chirality

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“…The solvent strength parameters for different solvents on alumina [1,3,5,15] and silica [3,5,9,25] were gathered from the references indicated. These are the most recent values and considered to be the most reliable based on opinions expressed in the sources quoted.…”

Section: Calculation Methodsmentioning

confidence: 99%

“…This is reasonable in practice since alkane solvents have minimal elution power on inorganic oxides. Dimethyl sulfoxide has a recommended value of 0.78 on alumina [15] and methyl t-butyl ether 0.48 on silica [3]. The solvation parameter model predicts small values for the solvent strength parameter for the alkane solvents (pentane = 0.06, hexane = 0.02, heptane = 0.01 andisooctane = 0.06 on alumina and pentane = 0.06 and hexane = 0.02 on silica) and a decrease in elution strength with increasing solvent volume.…”

Section: S-164mentioning

confidence: 99%

“…Application of the above method requires that the solute adsorption cross-sectional area and adsorbent activity are available by measurement or calculation. Although the solvent strength parameter is an empirical parameter, it has been correlated to more general solvent strength scales, such as Reichardt's ET (30 ) scale [13] and Kamlet-Taft's solvatochromic model [14,15]. A general equation has been given for the solvent strength of binary (and higher order) solvent mixtures which relates the mole fraction of solvents in the mobile phase to the solvent strength parameter for the pure solvents [3, 5 7, 12].…”

Section: Introductionmentioning

confidence: 99%

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A method for estimating the solvent strength parameter in liquid-solid chromatography

Poole

2001

Chromatographia

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The intermolecular interactions responsible for the adsoprtion of solvents on alumina and silica are chracterized using the solvation parameter model. Both adsorbents retain solvents by strong hydrogen bond and dipoledype interactions. Alumina is significantly more hydrogenbond basic and less hydrogen-bond acidic than silica, while both adsorbents are reasonably dipolar/polarizable. Increasing solvent size reduces polar adsorbent interactions. Models are presented that enable the solvent strength parameter, ~o, to be estimated for a wide range of solvents on alumina and silica to about 0.045 and 0.037 units, respectively. These models can be used to estimate from structure additional solvent strength parameter values for useful liquid-solid chromatographic solvents that lack consensus experimental values.

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Correlation of the eluting strengths of solvents in adsorption chromatography with solvatochromic parameters

Cited by 5 publications

References 24 publications

Linear Solvation Energy Relationship of the Limiting Partition Coefficient of Organic Solutes between Water and Activated Carbon

Linear Solvation Energy Relationship of the Limiting Partition Coefficient of Organic Solutes between Water and Activated Carbon

Evaluation of the specific intermolecular interactions responsible for chiral selectivity for phenylalanine analogs in subcritical fluid chromatography

A method for estimating the solvent strength parameter in liquid-solid chromatography

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