Correlation of the time course of development and decay of tolerance to morphine with alterations in sodium pump protein isoform abundance

Maguma, Hercules T.; Thayne, Kathleen; Davis, Barbara J.; Taylor, David A.

doi:10.1016/j.bcp.2009.11.003

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…These results were not unexpected, as chronic opioid agonist administration has previously been shown to decrease body weight (Binsack et al 2006; Levine et al 1998; Li et al 2010; Mitzelfelt et al 2011), and suggest that fentanyl has a greater effect on older individuals than younger individuals, which is a concern in a clinical setting.…”

Section: Discussionmentioning

confidence: 51%

Thermal sensitivity across ages and during chronic fentanyl administration in rats

2013

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Rationale Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals. As such, prescribed use of opioids is on the rise, even though the efficacy for pain management in older individuals is unclear. Objectives Thus the present preclinical study assessed the effectiveness of chronic fentanyl administration to produce antinociception in aging rats (16, 20, 24 months). Methods Animals were tested in a thermal sensitivity procedure known to involve neural circuits implicated in chronic pain in humans. Sensitivity to heat and cold thermal stimulation was assessed during 28 days of fentanyl administration (1.0 mg/kg/day), and 28 days of withdrawal. Results Fentanyl resulted in decreased thermal sensitivity to heat but not cold stimulation indicated by more time spent in the hot compartment relative to time spent in the cold or neutral compartments. Unlike previous findings using a hot-water tail withdrawal procedure, tolerance did not develop to the antinociceptive effects of fentanyl over a 28-day period of drug administration. The oldest animals were least sensitive, and the youngest animals most sensitive to the locomotor-stimulating effects of fentanyl. The effect on the antinociceptive response to fentanyl in the oldest group of rats was difficult to interpret due to profound changes in the behavior of saline-treated animals. Conclusions Overall, aging modifies the behavioral effects of opioids, a finding that may inform future studies for devising appropriate treatment strategies.

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Section: Discussionmentioning

confidence: 51%

Thermal sensitivity across ages and during chronic fentanyl administration in rats

2013

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“…Since animal studies show that TENS activates opioids receptors to produce analgesia, repeated TENS applications could cause analgesic tolerance similar to long-term use of opioids [43]. Although analgesic tolerance to TENS has been demonstrated in rats [9,17,19], this is the first study designed to address specifically the analgesic tolerance to TENS in humans.…”

Section: Discussionmentioning

confidence: 99%

“…Repeated stimulation of opioid receptors by repeated administration of morphine or opioid analgesics can lead to an analgesic tolerance defined as a decrease in analgesic effectiveness with repeated use [43]. In a similar way, repeated utilization of therapeutic electrophysical agents that reduce pain through release of endogenous opioids could have a gradual diminution of their analgesic effect.…”

Section: Introductionmentioning

confidence: 99%

An investigation of the development of analgesic tolerance to TENS in humans

Liebano

Rakel

Vance

et al. 2011

Pain

116

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“…Bodnar, 2004), and in general it is known that acute administration of opioid agonists increases food consumption in rats (Sanger & McCarthy, 1981) while opioid antagonists decrease food consumption (Glass et al, 1999; McLaughlin & Baile, 1983; Yuan et al, 2009). However, studies looking at chronic administration of morphine show decreases in food intake and body weight (Binsack et al, 2006; Levine et al, 1988; Li et al, 2010), while chronic opioid antagonist administration increases food consumption and weight gain (Chen et al, 2004). As hypothesized, chronic fentanyl administration resulted in a decreased food consumption within the first week, and animals became tolerant to this effect as food consumption had returned to baseline after four weeks of fentanyl administration.…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic fentanyl administration on physical performance of aged rats

Mitzelfelt

DuPree

Seo

et al. 2011

Experimental Gerontology

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There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fentanyl administration (1.0 mg/kg/day) on various physiological and behavioral measures. Continuous fentanyl administration resulted in an initial decrease in food consumption, followed by the development of tolerance to this effect over a 4-week period and a subsequent increase in food consumption during withdrawal. This change in food consumption was associated with decreases in body weight (predominantly due to a loss of fat mass) that was maintained through early withdrawal. After one month of withdrawal, only the 12-month old animals had fully regained body weight. Fentanyl administration resulted in a decrease in grip strength and an increase in locomotor activity that did not differ across age groups. There was no effect of fentanyl administration on rotarod performance. These results demonstrate that while there is a delayed recovery of body mass with age, the observed changes in behavioral responses are uniform across ages.

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Correlation of the time course of development and decay of tolerance to morphine with alterations in sodium pump protein isoform abundance

Cited by 10 publications

References 26 publications

Thermal sensitivity across ages and during chronic fentanyl administration in rats

Thermal sensitivity across ages and during chronic fentanyl administration in rats

An investigation of the development of analgesic tolerance to TENS in humans

Effects of chronic fentanyl administration on physical performance of aged rats

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