Correlation of tissue constituents with the acoustic properties of skin and wound

Olerud, John E.; O’Brien, William D.; Riederer-Henderson, Mary Ann; Steiger, Dianne L.; Debel, Judith R.; Odland, George F.

doi:10.1016/0301-5629(90)90086-r

Cited by 40 publications

(13 citation statements)

References 12 publications

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“…This relationship is consistent with previous results showing that the nonlinearity parameter can also be predicted using mixture laws [Apfel, 1986;Sehgal et al, 1986]. The weakly linear (marginally significant) relationship between attenuation coefficient and density found here is also consistent with a previous study, which showed that in canine skin and wound tissue the correlation between attenuation coefficient and collagen content was substantially smaller than the correlation between sound speed and collagen content [Olerud et al, 1990].…”

Section: Discussionsupporting

confidence: 94%

“…Since the bulk acoustic properties of tissue are fairly wellcharacterized by mixture laws [Apfel, 1986;Sehgal et al, 1986;Hachiya and Ohtsuke, 1994], it seems reasonable to conclude that the present empirical linear relationships relate straightforwardly to tissue composition. Proteins such as collagen have a sound speed and density higher than water [Goss and Dunn, 1980], so that tissues with higher concentrations of collagen and other proteins have relatively higher density and sound speed [O'Brien, 1977;Goss et al, 1980a;Olerud et al, 1990]. Similarly, lipids have lower sound speeds and density than water, so that tissues with greater fat content have relatively lower sound speeds and densities.…”

Section: Discussionmentioning

confidence: 97%

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Empirical relationships between acoustic parameters in human soft tissues

Mast

2000

Acoustics Research Letters Online

333

215

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Previously published summaries of sound speed, density, attenuation coefficient, and nonlinearity parameter, B/A, in human soft tissues are quantitatively analyzed. A highly significant empirical linear relationship is found to hold between sound speed and density for a wide range of soft tissues, including adipose, parenchymal, muscular, and connective tissues as well as body fluids. Even higher correlations occur between nondimensional parameters describing density variations and compressibility variations. Values for the nonlinearity parameter correlate significantly with sound speed and density, while the attenuation coefficient is found not to correlate significantly with any of the other parameters considered. Implications for tissue modeling and quantitative ultrasonic imaging are discussed.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Empirical relationships between acoustic parameters in human soft tissues

Mast

2000

Acoustics Research Letters Online

333

215

View full text Add to dashboard Cite

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“…Collagen synthesis and deposition are important for wound healing and development of wound strength (Falanga 2005). Various studies have shown that collagen production could be promoted by some mechanical stimuli, such as ultrasound (Olerud et al 1990), pulsating electromagnetic field (Murray and Farndale 1985) and mechanical pressure or stretch force (Chan et al 2010). In this study, we observed that the enhanced wound breaking strength correlated well with the increased hydroxyproline content in both ESWT groups.…”

Section: Discussionsupporting

confidence: 55%

Extracorporeal Shock Wave Treatment Improves Incisional Wound Healing in Diabetic Rats

Yang

Luo

Yan

et al. 2011

Tohoku J. Exp. Med.

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Impaired wound healing in surgical patients with diabetes increases the incidence of infection, prolongs hospitalization, and even increases the rate of mortality. Low-energy extracorporeal shock wave treatment (ESWT) was reported to accelerate chronic wound healing by promoting revascularization and tissue regeneration; however, it is not known if ESWT could also improve healing of acute surgical incisional wounds in diabetes. In this study, using a rat model of diabetes, we investigated the effect of low-energy ESWT on collagen content in wound tissues and its efficacy in incisional wound healing. A single dorsal incisional wound was inflicted in streptozotocin-induced diabetic rats, and they received ESWT at different time post-wounding. Rats were sacrificed on days 7 and 14 post-wounding. Wound breaking strength, hydroxyproline content, histological characteristics and the expression of transforming growth factor beta 1 (TGF-β1) were analyzed. As a result, the wound breaking strength was significantly enhanced and the hydroxyproline content in wound tissues was increased at each time point examined. The number of fibroblasts was significantly increased, and the new collagen fibers were more abundant at the wound site after ESWT. Furthermore, the expression of TGF-β1 was up-regulated after ESWT on day 7 post-wounding. These results suggest that low-energy ESWT can increase collagen content, enhance wound breaking strength and improve the healing of incisional wound in diabetic rats. The increased collagen content may be attributed, at least in part, to the up-regulation of TGF-β1 expression in wound tissues.

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“…We observed homogenous hypoechoic areas when raphae wound was healed completely. Similar result has been reported by Olerud et al (1990). They had demonstrated the disordered collagen fibres of a 3-month-old scar as echo-poor image.…”

Section: Resultssupporting

confidence: 79%

Ultrasonographic monitoring of abdominal wound healing in ewes

et al. 2017

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Objective: The present study was done to monitor the progress of abdominal wound healing after experimental laparotomy in ewes using Doppler ultrasonography. Materials and methods: Laparotomy was performed in seven apparently healthy indigenous ewes for collection and transfer of embryos. Wound morphology was studied in terms of width of sutured area of internal wound (ventral raphae) and swelling of suture areas, width and contraction rate of external wound. Internal wound healing process was monitor at two days interval by real time B-mode ultrasonography using transabdominal (13 MHz frequency) transducer. The echoes focus or zone of best resolution was adjusted to the point of interest on the screen. Results: The average widths of raphae wounds declined from 7.7±0.18 mm on day 0 to 0.9±0.34 mm on day 20 and were completely healed on day 22 in all ewes. The average widths of skin wound decreased to 0.36±0.14 mm on day 26 from 8.6±0.33 mm on day 0. Conclusion: It was observed that internal wound healed rapidly than external wound.

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Correlation of tissue constituents with the acoustic properties of skin and wound

Cited by 40 publications

References 12 publications

Empirical relationships between acoustic parameters in human soft tissues

Empirical relationships between acoustic parameters in human soft tissues

Extracorporeal Shock Wave Treatment Improves Incisional Wound Healing in Diabetic Rats

Ultrasonographic monitoring of abdominal wound healing in ewes

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