Correlation of trace elements (serum zinc and copper) in type 2 diabetic patients with and without complications

Abstract

Introduction: Type 2 diabetes mellitus (DM) is supposed to be associated with alteration in the serum levels of trace elements. Conversely, research also suggests that imbalances of specific elements associated with the complications of diabetes mellitus. Copper plays important role in oxidative stress and it's one of the important factor contributes to aetiology of DM. And zinc involved with synthesis & secretion of insulin. So, we have choose copper and zinc to find association in diabetics patients. Materials and Methods:In this cross sectional observational study total of one hundred and twenty (120) subjects were included and categorized into 3 groups. On the basis of screening, 80 patients were divided into two study groups: Group I (40 patients with micro-or macrovascular complications) and Group II (40 diabetic patients without complications). Group III include the 40 age and sex matched non-diabetic healthy control subjects selected for comparison. Serum zinc, copper concentration and HbA1c% (glycated haemoglobin) were estimated in all three study groups. Result: Serum copper concentration and HbA1c% were significantly (p<0.05) higher in diabetic patients (with and without complication) compared to control group. And serum copper shows significant (p<0.01) positive correlation with HbA1c% in both diabetic study groups. Serum zinc concentration was significantly (p<0.05) lower in diabetic patients (with and without complication) compared to healthy control group. And serum zinc shows significant (p<0.01) negative correlation with HbA1c% in both diabetic groups. Conclusion: Alteration in levels of trace elements (like, Zn and Cu) are found to be important influencing factors for diabetic patients for developing complications. From the present study, it may be determined that altered levels of trace elements (like zinc and copper) may have contributory a role in the pathogenesis and progression of type 2 DM.

Fetuin-A, Preptin, and Ceruloplasmin: A Possible Link Between Chronic Periodontitis and Diabetes Mellitus: A Review

“…Coexistence of periodontitis in diabetic patients is attributed to failure of the body's immune system to completely eliminate the source of inflammation such as microorganisms, this in turn, keeps the inflammatory process continuously activated, therefore, a chronic inflammatory reaction is induced (9) .This chronic inflammatory response is the main etiologic factor of systemic upregulation of different pro-inflammatory cytokines such as interleukins (IL-1β, 4, 6, 8, and 10) as well as tumor necrosis factor-α (TNF-α) (10,11) .…”