Correlation of trans fatty acids with the severity of coronary artery disease lesions

Ahmed, Samia Hadj; Kharroubi, Wafa; Kaoubaa, Nadia; Zarrouk, Amira; Batbout, F.; Gamra, Habib; Najjar, Mohamed Fadhel; Lizard, Gérard; Hininger‐Favier, Isabelle; Hammami, Mohamed

doi:10.1186/s12944-018-0699-3

Cited by 49 publications

(25 citation statements)

References 51 publications

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“…Besides, likewise former findings all lipid profile and AIP showed a significantly positive correlation, while a significant negative correlation was found between HDL and AIP in both groups [ 41 , 42 ]. Dietary fatty acids, determine the risk and protection of chronic diseases due to the chain length, number, and position of the double bonds as well as their shape (cis or trans) [ 43 – 45 ]. Therefore, fat quality intake can directly or indirectly have a profound effect on blood pressure and atherosclerosis [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

The correlation between dietary fat quality indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study

et al. 2020

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Background and aim Abnormalities in lipid metabolism are commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices might affect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers. Methods This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n = 71 normal, Age: 38.90 ± 10.976 vs n = 86 overweight/obese, Age: 38.60 ± 9.394) in the age range of 18–65 years. Food intake was measured using FFQ, anthropometric indices (weight, height, body mass index and waist to hip ratio), body composition (visceral fat level, total body water, body fat mass), and lipid profile were measured. Results Based on the present results, comparable biochemical parameters including TC (P = 0.580), TG (P = 0.362), LDL (P = 0.687) and HDL (P = 0.151) among overweight/obese volunteers as compared to normal ones were noticed. Effects of dietary fat quality, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) showed significantly higher AI (P = 0.012) in the overweight/obese group as compared to the normal group. Whereas, h/H (P = 0.034) and ω-6/ω-3 ratio (P = 0.004) were significantly higher in normal-weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. Despite the significances of these correlations no strong relation was observed by doing multiple regression among normal and overweight/obese groups (R2 = 0.210, R2 = 0.387). Conclusions In summary, the present work proposes a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. Nevertheless, further large-scale studies are required to sustain a clear conclusion in this wish.

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Section: Discussionmentioning

confidence: 99%

The correlation between dietary fat quality indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study

et al. 2020

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“…According to Cabiddu et al [37], animals fed diets based on herbage only, similar to the pasture-fed group of our study, had a significantly lower level of UTFA (0.29 mg/100 g of FA) compared with L (0.49 mg/100 g of FA) and F (0.73 mg/100 g of FA) (p < 0.01), probably because linseeds are rich in the precursors of these putatively noxious FAs. Several studies have highlighted the importance of not only increasing the content of health-promoting FAs but also decreasing the level of potentially harmful saturated and trans FAs, such as UTFAs (C18:1 t9 + C18:2 t9, t12) when developing human health care products [27,37,54]. A positive association between increased circulating low-density lipoprotein (LDL) levels and UTFA intake has been shown to alter or promote the relationship between the LDL atherosclerosis and coronary artery disease [54].…”

Section: Intramuscular Fatty Acid Compositionmentioning

confidence: 99%

“…Several studies have highlighted the importance of not only increasing the content of health-promoting FAs but also decreasing the level of potentially harmful saturated and trans FAs, such as UTFAs (C18:1 t9 + C18:2 t9, t12) when developing human health care products [27,37,54]. A positive association between increased circulating low-density lipoprotein (LDL) levels and UTFA intake has been shown to alter or promote the relationship between the LDL atherosclerosis and coronary artery disease [54].…”

Section: Intramuscular Fatty Acid Compositionmentioning

confidence: 99%

Effect of Ewe Diet on Milk and Muscle Fatty Acid Composition of Suckling Lambs of the Protected Geographical Origin Abbacchio Romano

Fusaro

Giammarco

Chincarini

et al. 2019

Animals

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Consumers increasingly pay more attention to the lipid profile of meat products and consume less meat to reduce cholesterol and heart disease. In Italy, sheep producers are increasingly feeding sheep fresh forage. We investigated whether the supplementation of dam diet with extruded linseed would be an alternative strategy to pasture for improving the intramuscular and subcutaneous FA compositions of their suckling lambs. The ewe diets were enriched with either extruded linseed (L), un-supplemented farm diet (F), or pasture (P). Milk saturated fatty acids (SFA) decreased in P and L compared with F, while the opposite pattern was observed for polyunsaturated FA (PUFA) and conjugated linoleic acids after seven days. The FA composition of lamb meat was similar to that of their dam’s milk, showing higher PUFA in P and L compared to F, while SFA was higher in F. Regarding the lamb meat obtained from barn-held ewes, L had lower n-6/n-3 content compared to F, while an intermediate content was found in P. These results indicate a better n-3 FA profile in milk and lamb’s meat from pasture and linseed-enriched diets. No changes in lamb performance were observed.

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“…Among saturated fatty acids (FAs) only palmitic acid increased mortality in patients with cardiovascular disease [ 14 ]. High levels of trans fatty acids have been associated with inflammation and oxidative stress in coronary heart disease [ 15 ]. Many findings suggest the role of long-chain polyunsaturated fatty acids belonging to n-3 and n-6 series in the membrane modulation, eicosanoid metabolism, gene expression, and cellular signaling [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of rosuvastatin on the concentration of each fatty acid in the fraction of free fatty acids and total lipids in human plasma: The role of cholesterol homeostasis

Ciucanu

Olariu

Vlad

et al. 2020

Biochemistry and Biophysics Reports

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Each fatty acid (FA) or class of FAs has a different behavior in the pathologies of atherosclerosis. The aim of this study was to investigate changes in the concentration of each fatty acid in the fraction of free fatty acids (FFAs) and total lipids in human plasma after short-term therapy with rosuvastatin as a cholesterol-lowering statin drug. Six hypercholesterolemic men on a habitual diet were studied in a randomized, double-blind, and crossover process. They received 20 mg rosuvastatin or placebo in random order, each for 4 weeks and after 2 weeks of washout period, they received another medication (placebo or rosuvastatin) for another period of 4 weeks. Rosuvastatin treatment significantly decreased the absolute concentrations of saturated and monounsaturated FAs in the total FAs as well as in FFAs. Long chain polyunsaturated fatty acids with 20 and 22 carbon atoms in the molecule had no significant change in the fraction of FFAs. Rosuvastatin is directly involved in cholesterol biosynthesis and indirectly through cholesterol homeostasis in the biosynthesis of other plasma lipids. In conclusion, our findings show that rosuvastatin treatment leads to significant changes in the concentration of each fatty acid, except for long-chain polyunsaturated fatty acids in FFAs. Our observations indicate that cholesterol homeostasis through its regulatory mechanisms appears to be the main cause of changes in the concentration of each plasma fatty acid during rosuvastatin treatment. These changes can be a source of beneficial consequences, in addition to lowering low-density lipoprotein cholesterol in cardiovascular diseases.

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Correlation of trans fatty acids with the severity of coronary artery disease lesions

Cited by 49 publications

References 51 publications

The correlation between dietary fat quality indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study

The correlation between dietary fat quality indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study

Effect of Ewe Diet on Milk and Muscle Fatty Acid Composition of Suckling Lambs of the Protected Geographical Origin Abbacchio Romano

Effect of rosuvastatin on the concentration of each fatty acid in the fraction of free fatty acids and total lipids in human plasma: The role of cholesterol homeostasis

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