Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer

Kim, Sung Hyun; Seo, Bo Kyoung; Lee, Jun-Young; Kim, Seok Jin; Cho, Kyu Ran; Lee, Ki Yeol; Je, Bo Kyung; Kim, Hee Young; Kim, Young Sik; Lee, Ju Han

doi:10.1080/02841860801971413

Cited by 77 publications

(85 citation statements)

References 18 publications

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“…Our results are consistent with prior studies (Kim et al, 2008;Ko et al, 2010) , which reported that expression of the HER2 oncogene strongly correlated with presence of calcification on ultrasound or mammography that may be related to prognosis. In addition, we found that the ultrasound findings among HER2 positive cancers were most commonly a mass without echogenic halo, which is defined as one of back scattering in US.…”

Section: 8057 Ultrasound Utility For Predicting the Biological Behavsupporting

confidence: 83%

“…Some studies also have discussed the features of triple-negative breast cancers (negativity of ER, PR, and HER2) (Dogan et al, 2010;Ko et al, 2010;Dogan et al, 2012;Krizmanich et al, 2012;Wojcinski et al, 2012;Li et al, 2014). However, correlations between ER, PR, HER2 and ultrasound findings in previous studies were varied and none had calculated the logistic regression model for reliable identification of molecular status (Kim et al, 2008;Wang et al, 2008;Au et al, 2009;Dogan et al, 2010;Ko et al, 2010a;2010b;Dogan et al, 2012;Krizmanich et al, 2012;Wojcinski et al, 2012;Irshad et al, 2013). The aim of this retrospective study was thus to 1)evaluating the correlation of images findings with the corresponding molecular features, 2)characterizing the various ultrasound features in breast cancer by using logistic regression models, in order to identify the factors that might help in predicting the status of molecular.…”

Section: Ultrasound Utility For Predicting Biological Behavior Of Invmentioning

confidence: 99%

“…Lei Zhang, Yu-Jie Liu, Shuang-Quan Jiang, Hao Cui, Zi-Yao Li, Jia-Wei Tian* ultrasound features and certain types of biologic behavior (Kim et al, 2008;Wang et al, 2008;Au et al, 2009;Ko et al, 2010;Irshad et al, 2013). Some studies also have discussed the features of triple-negative breast cancers (negativity of ER, PR, and HER2) (Dogan et al, 2010;Ko et al, 2010;Dogan et al, 2012;Krizmanich et al, 2012;Wojcinski et al, 2012;Li et al, 2014).…”

Section: Ultrasound Utility For Predicting Biological Behavior Of Invmentioning

confidence: 99%

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Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Zhang

Liu²,

Jiang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (19), 8057-8062 IntroductionDetermination of the molecular status of invasive breast cancer is useful as a prognostic and predictive factor, and it has become standard practice in the management of breast cancer because estrogen receptor (ER) and human epidermal growth factor receptor2 (HER2) positivity predict response to endocrine therapy or targeted therapy with monoclonal antibodies directed against HER2 (Bauer et al., 2007;Doreen et al., 2011). If it is possible to predict molecular status on the basis of imaging characteristics, it could assist in both pretreatment planning and prognosis, as well as add to our understanding of the biologic behavior of this disease.Breast ultrasound has gained widespread acceptance as an adjunct to mammography in diagnosis of evaluating clinical or radiological suspected abnormalities (Gordon et al., 1995;Rizzatto et al., 2001). Stavros et al. reported that it has high sensitivity (98.4%) and negative predictive (99.5%) value for diagnosing breast cancers (Stavros et al., 1995). Ultrasound (US), with its merits of safety and low cost, is becoming a preferred method for both physicians and patients. Hence, more attention is needed toward US imaging to determine whether certain type of tumor biologic factors can be predicted from imaging appearances.A few studies have looked into correlation between

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Section: 8057 Ultrasound Utility For Predicting the Biological Behavsupporting

confidence: 83%

Section: Ultrasound Utility For Predicting Biological Behavior Of Invmentioning

confidence: 99%

Section: Ultrasound Utility For Predicting Biological Behavior Of Invmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Zhang

Liu²,

Jiang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Several studies have previously correlated ultrasound features with the traditional prognostic markers, including histological tumour type [12][13][14][15][16], grade [16,17] and BRCA1 and BRCA2 mutations [18,19] as well as molec- Data are presented as number of occurrences (percentages in parentheses). Significant findings in bold *p=0.01; **p=0.05; ***p=0.04; ****p=0.007 ular markers (oestrogen receptor, progesterone receptor and HER2/neu) [16]. This study is to our knowledge the first to correlate ultrasound features of breast cancer with the new molecular classification groups [10].…”

Section: Discussionmentioning

confidence: 99%

Sonographic correlations with the new molecular classification of invasive breast cancer

et al. 2009

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Ultrasound is a useful adjunct to mammography for the characterisation and biopsy of solid breast lesions. Protein expression profiling of breast cancer has identified specific subgroups with potential clinical, biological and therapeutic implications. The aim of this study was to determine the ultrasound correlates of these novel molecular classes of invasive breast cancer. The ultrasound findings in 358 patients with operable breast cancer were correlated with the previously described protein expression classes identified by our group using immunohistochemical (IHC) assessment of a large series of breast cancer cases in which 25 proteins of known relevance in breast cancer were assessed, including hormone receptors, HER2 status, basal and luminal markers, p53 and e-cadherin. The proportion of occult lesions was not significantly different in the two groups. Significant differences were noted between the two groups expressing luminal epithelial markers and hormone receptors (1 and 2), including a greater proportion of ill-defined, irregular and distally attenuating tumours in group 2. Tumours characterised by c-erbB2/MUC1 expression, with weak hormone receptor positivity (group 3) were also more likely to be ill defined. Tumours expressing basal markers (group 5) were less likely to have an echogenic halo. The ultrasound features of breast cancer show areas of significant correlation with molecular classes of invasive breast cancer identified by IHC analysis. The biological reasons for these findings and their implications regarding imaging protocols require further study and may enable improved detection of these lesions.

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“…There are several studies assessing the correlations between various imaging findings for breast cancer diagnosis, including mammography, US, and magnetic resonance imaging, along with the clinical features and immunohistopathological markers (11)(12)(13). In this study, we focused on investigating the immuohistochemical characteristics of upgraded malignancy from highrisk and borderline lesions and to correlate the upgrade rates with clinical findings.…”

Section: Discussionmentioning

confidence: 99%

Upgraded Malignancy from High-Risk and Borderline Breast Lesions: Immunohistochemical and Clinical Characteristics

Park

Kang

Baek

et al. 2018

J Korean Soc Radiol

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Purpose:The purpose of this study was to investigate the immune-histochemical characteristics of upgraded malignancy from high-risk and borderline breast lesions, and to correlate the upgrade rates with clinical findings. Materials and Methods:We scrutinized image-guided biopsy records retrospectively, and included all women afflicted with high-risk and borderline breast lesions during the period, 2011 to 2015, inclusive. A total of 340 high-risk and borderline lesions were identified by the pathologist in biopsy samples and thereafter, surgical excision and/or image follow-up for at least 24 months was performed. We compared the clinical emanating from both high-risk and borderline lesions, and with and without cancer upgrade. In the instances of lesions with cancer upgrade, histologic and immuohistochemical reviews were performed. Results: Of the 340 high-risk or borderline lesions, 18.8% (64/340) were upgraded. The upgrade rates were higher in patients of more advanced age, larger body habitus and afflicted with atypical ductal hyperplasia rather than with other pathology (p < 0.05). In the lesions with cancer upgrade (n = 64), there was no lymph node metastasis. The estrogen receptor-positive (93.8%), progesterone receptor-positive (87.5%), human epidermal growth factor receptor type 2-negative (90.6%), Ki-67-negative (82.8%), and Luminal A (76.6%) types were seen more frequently. Conclusion: Most upgraded malignancies arising from high-risk and borderline breast lesions were found to be Luminal A-type with good prognostic factors, and the upgrade rates correlated with clinical characteristics.

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Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer

Cited by 77 publications

References 18 publications

Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Sonographic correlations with the new molecular classification of invasive breast cancer

Upgraded Malignancy from High-Risk and Borderline Breast Lesions: Immunohistochemical and Clinical Characteristics

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