Correlation of Uric Acid with Disease Severity, Prognosis, and Complications in Patients with Severe Acute Pancreatitis

Abstract

This study aimed to investigate the role of serum uric acid (UA) in early identification of the severity, prognosis and complications in patients with severe acute pancreatitis (SAP). The clinical data of SAP patients were collected retrospectively (n=268), and patients were divided into high UA group and low UA group based on the median UA level. Propensity score matching was used to make the baseline data comparable, and 85 patients were selected in each group. Spearman correlation analysis was performed to assess the relationship between UA level and severity and prognosis. The ROC curve was designed to evaluate the ability of UA to predict complications. In the high UA group, disease severity scores were higher, ICU stay and total hospital days were longer. UA levels were found to be positively associated to disease severity scores, ICU stay and total hospital days. The ROC curve revealed that the UA level had an useful predictive value for infectious pancreatic necrosis (IFN). UA level can be used as a convenient indicator of disease severity and IFN risk in SAP patients.