Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma – An Insight into Pathogenesis

Vara, Joy Thomas; Gurudu, Vijay Srinivas; Ananthaneni, Anuradha; Bagalad, Bhavana S; Kuberappa, Puneeth Horatti; Ponnapalli, Hari Priya

doi:10.7860/jcdr/2017/24614.9840

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…PG frequently developed in pregnant women and the term “pregnancy tumor” had been used in these cases [ 1 ], which had high recurrence rate after treatment [ 27 ]. Another explanation was that PG were histologically highly vascular proliferative lesions and the vascular endothelial growth factor was related to the angiogenesis and rapid growth of PG [ 28 ]. Estrogen could enhance vascular endothelial growth factor production [ 29 ], therefore relating to the recurrence.…”

Section: Discussionmentioning

confidence: 99%

A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence

et al. 2023

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Background To analyze the clinicopathological features of different histological subtypes of epulis, and evaluate the risk factors associated with recurrence. Materials and methods A retrospective study including 2971 patients was performed. The patients’ sex, age, location, size, histological subtypes, recurrence information, oral hygiene habits, periodontitis symptoms and smoking history were retrieved from the patient medical records and follow-up information. Results Among the 2971 cases, focal fibrous hyperplasia (FFH) was the most common lesion (60.92%), followed by peripheral ossifying fibroma (POF) (29.32%), pyogenic granuloma (PG) (8.08%) and peripheral giant cell granuloma (PGCG) (1.68%). The peak incidence of epulis was in the third and fourth decade of life, with a mean age of 45.55 years. Female predominance was found in all types of lesions with a female to male ratio of 1.71:1. PG had the highest recurrence rate (17.18%), followed by POF (12.98%), FFH (9.55%) and PGCG (8.82%). Histological subtypes were significantly correlated with the recurrence of epulis (P = 0.013). Regular supportive periodontal therapy (P = 0.050) had a negative correlation with recurrence, whereas symptoms of periodontitis (P < 0.001) had a positive correlation with the recurrence of epulis. Conclusions Controlling the periodontal inflammation and regular supportive periodontal therapy might help reduce the recurrence of epulis.

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Section: Discussionmentioning

confidence: 99%

A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence

et al. 2023

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“…In PG, VEGF and FGF-2 have been shown to play vital roles in its angiogenesis, which could be produced mainly by endothelial cells and inflammatory cells. [10][11][12] Previously, some reports revealed that melanocytic nevus had no or low expression of VEGF. 13,14 As for FGF-2, Giehl et al 15 reported that 55% cases of melanocytic nevus expressed FGF-2, and the staining intensities were moderate except for one case with strong staining.…”

Section: Discussionmentioning

confidence: 99%

“…The gross findings and overall histological findings with epidermal collarettes and numerous blood vessels in the superficial dermis of the nodule in our case resembled PG, suggesting that a similar pathogenesis of PG may be involved in the angiogenesis of the ASN. In PG, VEGF and FGF‐2 have been shown to play vital roles in its angiogenesis, which could be produced mainly by endothelial cells and inflammatory cells . Previously, some reports revealed that melanocytic nevus had no or low expression of VEGF .…”

Section: Discussionmentioning

confidence: 99%

Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Anju

Nakamura

Okiyama

et al. 2020

The Journal of Dermatology

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Angiomatoid Spitz nevus (ASN) is a rare histological variant of Spitz nevus (SN) that is characterized by prominent blood vessel proliferation around the intradermal melanocytes of SN. In contrast, SN may have pagetoid components, which are characterized by epidermal proliferation of single melanocytes. However, cases of ASN with predominant pagetoid melanocytic proliferation in the epidermis have not been reported. Here, we report a case of ASN with surrounding pagetoid melanocytic proliferation without formation of tumor nests in the epidermis in the plantar region. A 12-year-old girl presented with a bright red nodule surrounded by a brown macule on the sole of her right foot. Histologically, the nodule showed tumor nests in the dermis, composed of spindle or epithelioid melanocytes containing abundant cytoplasm and large nuclei. Around the nests, numerous blood vessels were seen. In the overlying epidermis of the nodule, numerous eosinophilic Kamino bodies were found along the dermal-epidermal interface. In the macule, proliferation of oval melanocytes was present as single-cell units in the epidermis. Theses melanocytes had abundant cytoplasm with large nuclei, which were larger than those of the surrounding keratinocytes. From these findings, a diagnosis of ASN with surrounding pagetoid melanocytic proliferation was made. Vascular endothelial growth factor and fibroblast growth factor 2 were strongly expressed in the melanocytes as well as in the endothelial cells in our case. Therefore, angiogenic factors produced by the melanocytes of SN might have played important roles in the surrounding angiogenesis of this case.

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“…Branch retinal vein occlusion is associated with small collections of retinal neovascularization overlying visibly occluded veins [12]. In contrast, pyogenic granulomas form as an acute response to injury that will remain static as inflammation resolves, whereas diabetic retinopathy and retinopathy associated with branch retinal vein occlusion are chronic processes, with long-term increases in VEGF contributing to their progressive nature [10, 13]. …”

Section: Discussionmentioning

confidence: 99%

Pyogenic Granuloma of the Retina: A Case Series

2018

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Aim: To describe the clinicopathologic features of pyogenic granuloma (granulation tissue proliferation) extending from the retina. Methods: We describe 3 patients who underwent enucleation for endophthalmitis. The eyes were processed routinely for histopathologic examination. Results: All 3 enucleated eyes contained granulation tissue with reactive vascular channels and intervening stroma infiltrated with inflammatory cells. The vascular channels were arranged in a fan-like configuration and the tissue was classified as representing pyogenic granulomas. Conclusions: Pyogenic granulomas (granulation tissue) may emanate from the retina in cases of endophthalmitis. This is distinct from neovascularization that may occur in proliferative diabetic retinopathy, central retinal vein occlusion, or other etiologies.

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Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma – An Insight into Pathogenesis

Cited by 9 publications

References 11 publications

A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence

A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence

Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Pyogenic Granuloma of the Retina: A Case Series

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