Correlation of ventricular asymmetry with metabolic asymmetry in frontotemporal dementia

Jeong, Yoong Ki; Ym, Song; Pw, Chung; Ej, Kim; Kang, Sung-Jin; Jm, Kim; Ss, Cho; Se, Kim; Byun, Hongsik; Dl, Na

doi:10.1016/s0150-9861(05)83145-1

Cited by 9 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, other investigators of bvFTD show a left-sided frontotemporal role in social concepts (Pobric, Lambon Ralph, & Zahn, 2016) and in empathic concern or emotional processing (Dermody et al, 2016;Kamminga et al, 2015;Sturm et al, 2015). The common bilateral asymmetry of the frontal and temporal atrophy in bvFTD (Jeong et al, 2005), and the findings of a direction-independent asymmetry effect in this study, can explain this discrepancy in the literature.…”

Section: Discussioncontrasting

confidence: 72%

“…either left>right or right>left, asymmetry of the frontal or frontotemporal regions in patients with behavioral variant frontotemporal dementia (bvFTD) (Rascovsky et al, 2011). In early stages, bvFTD can affect one hemisphere more (Jeong et al, 2005). Reports show that right-sided predominant bvFTD results in impaired social conduct (Boccardi et al, 2005;Eslinger et al, 2007;B.…”

Section: Introductionmentioning

confidence: 99%

“…In a neuropathological examination with an asymmetry index (i.e., left-right asymmetry independent of direction) of advanced bvFTD patients, there was significant asymmetric pathology in frontotemporal regions (Irwin et al, 2018). However, some studies in bvFTD have not found asymmetric degeneration (Whitwell et al, 2013), and others report socioemotional dysfunction with either bilateral or focal left-sided involvement (Dermody et al, 2016;Jeong et al, 2005;Kamminga et al, 2015;Salmon et al, 2006;Tosun, Rosen, Miller, Weiner, & Schuff, 2012). These discrepancies may be due to the degree of directionindependent interhemispheric asymmetry present in patients with early or mid-stage bvFTD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Frontotemporal asymmetry in socioemotional behavior: A pilot study in frontotemporal dementia

Carr

Jimenez

Thompson

et al. 2019

Social Neuroscience

View full text Add to dashboard Cite

Clinical studies report abnormal socioemotional behavior in patients with right frontotemporal disease, but neuroimaging studies of socioemotional behavior usually show bilateral activations in normal subjects. This discrepancy suggests that impaired interhemispheric collaboration for socioemotional functions results from asymmetric frontotemporal disease. Behavioral variant frontotemporal dementia (bvFTD) is a good model for evaluating the contribution of directionindependent frontotemporal asymmetry. In a two-part study, we evaluated patients who met Clinical Consensus Criteria for bvFTD using socioemotional scales and magnetic and resonance imaging measures. Part A compared 18 patients on scales of social dysfunction and emotional intelligence with degree of asymmetry in frontal lobe volumes and analyzed differences between lower and higher asymmetry groups. Part B compared 24 patients on scales of social observation and emotional blunting with degree of asymmetry in frontotemporal cortical thickness using multiple linear regression. Both results showed that left or right hemispheric-specific contributions did not account for all socioemotional differences and that frontal lobe and frontotemporal differences in atrophy between the hemispheres accounted for significant variance in abnormalities in social and emotional behavior. These preliminary results indicate that the degree of frontal lobe and frontotemporal asymmetric involvement, regardless of direction or laterality, significantly contribute to socioemotional dysfunction and support the hypothesis that interhemispheric collaboration is important for complex socioemotional behavior.

show abstract

Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frontotemporal asymmetry in socioemotional behavior: A pilot study in frontotemporal dementia

Carr

Jimenez

Thompson

et al. 2019

Social Neuroscience

View full text Add to dashboard Cite

show abstract

“…In other studies, hippocampal asymmetry was found to be reduced in subjects suffering from dementia (Barnes et al, 2005), specific regional hippocampal atrophy patterns were found in MCI and particularly in the left hippocampus (Apostolova et al, 2010), and in a meta-analysis Shi et al (2009) demonstrated that left hippocampi were smaller than right hippocampi in MCI and AD. Moreover, ventricular asymmetry has been shown to be associated with metabolic asymmetry in fronto-temporal dementia (Jeong et al, 2005), asymmetry in cortical metabolic activity in AD patients was correlated with cerebellar and basal ganglia metabolic asymmetry indexes (Akiyama et al, 1989), and amygdalar asymmetry discriminated between Alzheimer's disease and fronto-temporal lobar degeneration (Barnes et al, 2006). …”

Section: Introductionmentioning

confidence: 99%

Mild cognitive disorders are associated with different patterns of brain asymmetry than normal aging: the PATH through life study

et al. 2010

View full text Add to dashboard Cite

Background and Purpose: Defining how brain structures differ in pre-clinical dementia is important to better understand the pathological processes involved and to inform clinical practice. The aim of this study was to identify significant brain correlates (volume and asymmetry in volume) of mild cognitive disorders when compared to normal controls in a large community-based sample of young-old individuals who were assessed for cognitive impairment. Methods: Cortical and sub-cortical volumes were measured using a semi-automated method in 398 participants aged 64–70 years who were selected from a larger randomly sampled cohort and who agreed to undergo an MRI scan. Diagnoses were reached based on established protocols for MCI and a more inclusive category of any Mild Cognitive Disorder (any-MCD: which includes AAMI, AACD, OCD, MNC, CDR, MCI). Logistic regression analyses were used to assess the relationship between volume and asymmetry of theoretically relevant cerebral structures (predictors) and MCI or any-MCD while controlling for age, sex, and intra-cranial volume. Results: The main correlates of cognitive impairment assessed in multivariate analyses were hippocampal asymmetry (more to left, MCI: OR 0.83, 95%CI 0.71–0.96, p = 0.013; MCD: OR 0.86, 95%CI 0.77–0.97, p = 0.011), lateral ventricle asymmetry (more to left, MCI: OR 0.95, 95%CI 0.91–0.99, p = 0.009; MCD: OR 0.95, 95%CI 0.92–0.98, p = 0.004), and cerebellar cortex asymmetry (more to right, MCI: OR 1.51, 95%CI 1.13–2.01, p = 0.005). Conclusions: In this population-based cohort stronger associations were found between asymmetry measures, rather than raw volumes in cerebral structures, and mild cognitive disorders.

show abstract

“…In the late stages a significant hypometabolism is found mostly in extensive prefrontal areas, cingulate gyri, anterior temporal regions and the left inferior parietal lobule. Frontal hypometabolism is usually more prominent in the left hemisphere than in the right -in 79% of patients [21]. Therefore sociopathy in FTD may result from right frontotemporal dysfunction.…”

Section: Fronto-temporal Dementiamentioning

confidence: 99%

Nuclear Medicine in Psychiatry

Otte¹,

Audenaert²,

Peremans³

et al. 2004

View full text Add to dashboard Cite

show abstract

Correlation of ventricular asymmetry with metabolic asymmetry in frontotemporal dementia

Cited by 9 publications

References 30 publications

Frontotemporal asymmetry in socioemotional behavior: A pilot study in frontotemporal dementia

Frontotemporal asymmetry in socioemotional behavior: A pilot study in frontotemporal dementia

Mild cognitive disorders are associated with different patterns of brain asymmetry than normal aging: the PATH through life study

Nuclear Medicine in Psychiatry

Contact Info

Product

Resources

About