Correlation of visual functions with macular thickness in primary open angle glaucoma

Agrawal, Siddharth; Singh, Vinita; Bhasker, Shashi Kumar; Sharma, B.S.

doi:10.4103/0974-620x.116640

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…This shows that, other than clinically measured vision status, macular and GCIPL thickness also potentially contributes to good visual functioning. In healthy eyes, macular thickness can possibly aid in other areas crucial for visual functioning such as depth perception, contrast sensitivity, stereo-acuity, and visual fields, further supporting the role of macular thickness as a factor associated with better visual functioning 18,29 . Overall, despite the statistically significant associations observed between macular parameters and visual functions, it should also be noted that the observed effect estimates were generally small.…”

Section: Discussionmentioning

confidence: 87%

Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

Poh

Tham

Chee

et al. 2020

Sci Rep

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This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurements of best-corrected visual acuity (BCVA) and 11-item visual functioning questionnaire (VF-11) were performed. Associations between macular thickness parameters, with BCVA and Rasch-transformed VF-11 scores (in logits) were assessed using multivariable linear regression models with generalized estimating equations, adjusted for relevant confounders. 4,540 subjects (7,744 eyes) with a mean age of 58.8 ± 8.6 years were included. The mean BCVA (LogMAR) was 0.10 ± 0.11 and mean VF-11 score was 5.20 ± 1.29. In multivariable regression analysis, thicker macula (per 20 µm; β = −0.009) and GCIPL (per 20 µm; β = −0.031) were associated with better BCVA (all p ≤ 0.001), while thicker macula (per 20 µm; β = 0.04) and GCIPL (per 20 µm, β = 0.05) were significantly associated with higher VF-11 scores (all p < 0.05). In conclusion, among healthy Asian eyes, thicker macula and GCIPL were associated with better vision and self-reported visual functioning. These findings provide further understanding on the potential influence of macular thickness on visual function.

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Section: Discussionmentioning

confidence: 87%

Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

Poh

Tham

Chee

et al. 2020

Sci Rep

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“…Agrawal and colleagues found that CS and BCVA were strongly related to macular thickness with Cirrus HD-OCT in patients with primary open angle glaucoma. 32 Because of the redundancy of retinal ganglion cells in the human visual system, visual field damage tends to emerge when at least 25–30% retinal ganglion cells are lost. 33–36 A puzzling finding of our study was that the magnitude of the correlations between GC/IPL thickness measures and CS was not as high as the correlations of the latter with FT thickness measurements.…”

Section: Discussionmentioning

confidence: 99%

Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma

Fatehi

Nowroozizadeh

Henry

et al. 2017

American Journal of Ophthalmology

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PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6×3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p<0.001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ =−0.306, −0.348 and −0.241, p<0.013, respectively). CONCLUSIONS Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.

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“…There have not yet been any studies of the relationship between the thickness of each layer of the macula and visual acuity, although a previous study has reported that mean total macular thickness was significantly decreased in patients with poor BCVA [ 16 ]. Our study now confirms that both macular RNFLT and GCCT are also correlated with BCVA ( r value: approximately −0.4~0.5), although being weakly correlated.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma

Kobayashi

Kunikata

Omodaka

et al. 2015

Journal of Ophthalmology

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Purpose. To determine the correlation of reduced retinal thickness in the central papillomacular bundle (CPB) to central visual function, including central retinal sensitivity and visual acuity, in glaucoma patients. Methods. This study enrolled 50 eyes of 50 patients with open-angle glaucoma who were carefully screened for comorbid conditions that can cause decreased central visual function, such as cataracts or macular diseases. We used a novel CPB analysis comprising a program for optical coherence tomography that measured RNFL thickness and GCC thickness in the CPB and divided lengthwise into three parts (upper, middle, and lower CPB). The relationship of these parameters, including conventional macular thickness, to visual field sensitivity in four central standard automated perimetry points (the central four thresholds) and BCVA was analyzed. Results. The two parameters most highly correlated with central four thresholds were macular GCCT and macular RNFLT. The two parameters most highly correlated with BCVA were middle CPB (mid-CPB) GCCT and mid-CPB RNFLT. A multiple regression analysis revealed that mid-CPB GCCT was an independent factor impacting central retinal thresholds and BCVA. Conclusions. Our results suggest that mid-CPB RNFLT and GCCT, parameters of a novel papillomacular bundle analysis, are candidate biomarkers of decreased central visual function in glaucomatous eyes.

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Correlation of visual functions with macular thickness in primary open angle glaucoma

Cited by 4 publications

References 9 publications

Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma

Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma

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