Correlation of Vital Lung Capacity with Body Weight, Longitudinal and Circumference Dimensions

Pavlica, Tatjana; Božić-Krstić, Verica; Rakić, Rada

doi:10.1080/13102818.2010.10817856

Cited by 8 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Height has an impact on the lung function, as the vital capacity (VC) is affected by height [23]. With increasing age it is known that height decreases, in our study we found an annual decrease of 0.19 cm/year in females and 0.14 cm/year in males.…”

Section: Discussionsupporting

confidence: 49%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Erelund

Karp

Arvidsson

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function, stressing the importance of selecting consistant and reliable clinical reference data. This study aims to evaluate the results of lung function testing in subjects without known heart or pulmonary disease living in Northern Sweden, with a focus on a comparison with previously published reference materials. Methods The study is based on 285 (148 males) healthy adults, 20-90 years of age. The subjects had been randomly selected and included in a study of cardiac function in heart-healthy subjects and were also assessed with dynamic spirometry, where 16 subjects presented with pulmonary functional impairments and were excluded. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations are derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. A comparison was made with the reference values given by the original LMS model that is suggested by the Global Lung Initiative (GLI), and with the reference values from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, which is also based on subjects from Northern Sweden. Results No differences were found in the age-dependency of pulmonary function between the new LMS model and the OLIN model. The original GLI reference values suggested significantly lower normal values, and consequently resulted in fewer subjects with both FEV1 and FVC values below the lower limit of normality, than both the new model and the OLIN model. Conclusions Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model with values that are specific for Swedish citizens. For optimal accuracy the final coefficients should be verified in a larger cohort.

show abstract

Section: Discussionsupporting

confidence: 49%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Erelund

Karp

Arvidsson

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…With age, there are anatomical, physiological, and immunological changes that occur [ 13 , 14 , 15 ], ranging from decreased respiratory muscle strength to elasticity, which may affect the inhaled drug from effectively reaching the deep lungs. With gender differences, females have a 10–12% smaller lung volume than males of the same height and age [ 16 ]; for both sexes, taller individuals have a larger vital lung capacity [ 17 , 18 ]. With certain respiratory diseases such as COPD with severe airflow obstruction and hyperinflation, respiratory muscle function may be significantly impaired [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder

Gauani

Baker

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Treprostinil palmitil (TP), a prodrug of treprostinil, is being developed as an inhalation powder (TPIP) for the treatment of patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension due to interstitial lung disease (PH-ILD). In ongoing human clinical trials, TPIP is administered via a commercially available high resistance (HR) RS01 capsule-based dry powder inhaler (DPI) device manufactured by Berry Global (formerly Plastiape), which utilizes the patient’s inspiratory flow to provide the required energy to deagglomerate and disperse the powder for delivery to their lungs. In this study, we characterized the aerosol performance of TPIP in response to changes in inhalation profiles to model more realistic use scenarios, i.e., for reduced inspiratory volumes and with inhalation acceleration rates that differ from those described in the compendia. The emitted dose of TP for all combinations of inhalation profiles and volumes ranged narrowly between 79 and 89% for the 16 and 32 mg TPIP capsules at the 60 LPM inspiratory flow rate but was reduced to 72–76% for the 16 mg TPIP capsule under the scenarios at the 30 LPM peak inspiratory flow rate. There were no meaningful differences in the fine particle dose (FPD) at all conditions at 60 LPM with the 4 L inhalation volume. The FPD values for the 16 mg TPIP capsule ranged narrowly between 60 and 65% of the loaded dose for all inhalation ramp rates with a 4 L volume and at both extremes of ramp rates for inhalation volumes down to 1 L, while the FPD values for the 32 mg TPIP capsule ranged between 53 and 65% of the loaded dose for all inhalation ramp rates with a 4 L volume and at both extremes of ramp rates for inhalation volumes down to 1 L for the 60 LPM flow rate. At the 30 LPM peak flow rate, the FPD values for the 16 mg TPIP capsule ranged narrowly between 54 and 58% of the loaded dose at both extremes of the ramp rates for inhalation volumes down to 1 L. Based on these in vitro findings, the TPIP delivery system appears not to be affected by the changes in inspiratory flow profiles or inspiratory volumes that might be expected to occur in patients with PAH or PH associated with underlying lung conditions such as ILD.

show abstract

“…Both the LMS and OLIN models have introduced more complex non-linear models that provide a more reliable result of gender-specific spirometry outcomes, while also accounting for the subject’s age and height. Height has an impact on the lung function, as the vital capacity (VC) is affected by height [ 23 ]. With increasing age it is known that height decreases, in our study we found an annual decrease of 0.19 cm/year in females and 0.14 cm/year in males.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

et al. 2023

View full text Add to dashboard Cite

Background Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects. Methods The study population consisted of 285 healthy adults (148 males, 52%) between 20–90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model. Results No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV1 (forced expiratory volume) and FVC (forced vital capacity), and consequently fewer subjects below the lower limit of normality, than both the rederived LMS and OLIN models. Conclusions Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model based on a larger cohort of Swedish citizens than was available in this study.

show abstract

Correlation of Vital Lung Capacity with Body Weight, Longitudinal and Circumference Dimensions

Cited by 8 publications

References 1 publication

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden - A comparison of reference values

Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder

Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values

Contact Info

Product

Resources

About