Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome

Kumar, Arun; Barki, Satish; Raghav, Vinod; Chaturvedi, Ashutosh; Kumar, K V S Hari

doi:10.4103/2249-4863.214985

Cited by 30 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this issue, Hahn et al proposed that low vitamin D levels might be a primeval factor in the initiation and progression of PCOS, and that dietary abundance of vitamin D could help to restore normal menses in female with this syndrome (21). Several studies also assumed that vitamin D deficiency might be a causal factor in the pathogenesis of IR and the metabolic disturbance found in PCOS (22,23). In addition, recent studies which concluded that low vitamin D levels may aggravate the symptoms of PCOS, including IR, ovulatory dysfunction, irregular menses, impaired fertility, and hydperandrogenism (24,25).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Hamdi

Abdul-Qahar

Kadhum³

et al. 2018

JFacMedBagdad

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women ofreproductive age with primary features of infertility, menstrual irregularity, and clinical or biochemicalevidence of hyperandrogenism (hirsutism, acne and high androgen level). Vitamin D has a role in thedevelopment of metabolic and endocrine abnormalities in PCOS mediated by insulin resistance.Objective: Measure serum 25-hydroxy vitamin D levels in women with polycystic ovary syndrome andcompare their levels with age and body mass index matched healthy controls. Also, assess thecorrelation between insulin resistance and 25-hydroxy vitamin D among women with PCOS.Subjects and Methods: Eighty eight women were involved in this study with age range (18-34 years).Subjects were divided into two groups: Group 1- forty five women with PCOS and Group 2- forty threewomen without PCOS (as controls).Serum 25-hydroxy vitamin D, insulin, free testosterone, Luteinizing hormone (LH), Follicle stimulatinghormone (FSH) were measured by enzyme linked immunosorbent assay (ELISA), while serum calciumand fasting serum glucose were measured by spectrophotometer.Results: Significant increase in mean value of fasting serum glucose, insulin, homeostatic modelassessment of insulin resistance (HOMA-IR), LH, LH/FSH ratio, and free testosterone with significantdecrease in mean value of serum FSH, 25-hydroxy vitamin D, and calcium for patients with PCOScomparing to age and body mass index match controls. Additionally, significant negative correlationswere found between serum 25-hydroxy vitamin D levels with fasting serum glucose (r= -0.484, p=0.01),fasting serum insulin (r= -0.422, p=0.04), and HOMA-IR (r= -0.542, p=0.0001) in women with PCOS.Conclusion: Vitamin D has a role in metabolic and hormonal disturbance seen in PCOS through impactof vitamin D on insulin releasing and function.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Hamdi

Abdul-Qahar

Kadhum³

et al. 2018

JFacMedBagdad

View full text Add to dashboard Cite

show abstract

“…( 46 ) 44 PCOS women Data not available Negative correlation with HOMA-IR and insulin, positive correlation with HDL-cholesterol No correlation with testosterone Kumar et al . ( 50 ) 100 PCOS women 28.6 ± 6.3 years No correlation No correlation No correlation Data are given as mean ± s.d. or median (IQR) unless otherwise stated.…”

Section: Vitamin D and Pcosmentioning

confidence: 99%

Vitamin D, PCOS and androgens in men: a systematic review

Trummer¹,

Pilz²,

Schwetz³

et al. 2018

Endocrine Connections

View full text Add to dashboard Cite

BackgroundAccumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders.AimThe aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men.MethodsWe performed a systematic literature search in PubMed for relevant English language publications published from January 2012 until September 2017.Results and discussionThe vitamin D receptor and vitamin D-metabolizing enzymes are found in reproductive tissues of women and men. In women, vitamin D status has been associated with several features of PCOS. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin resistance as well as hyperandrogenism. Moreover, results from randomized controlled trials (RCTs) suggest that vitamin D supplementation may be beneficial for metabolic, endocrine and fertility aspects in PCOS. In men, vitamin D status has been associated with androgen levels and hypogonadism. Further, there is some evidence for a favorable effect of vitamin D supplementation on testosterone concentrations, although others failed to show a significant effect on testosterone levels.ConclusionIn summary, vitamin D deficiency is associated with adverse fertility outcomes including PCOS and hypogonadism, but the evidence is insufficient to establish causality. High-quality RCTs are needed to further evaluate the effects of vitamin D supplementation in PCOS women as well as on androgen levels in men.

show abstract

“…A study done by Zhang et al suggested that a low Vitamin D level is inversely related to HOMA-IR [35]. Studies done by Wher et al and Kumar et al showed the association of hypovitaminosis D with IR and obesity in women with PCOS [27,36]. VDR complex regulates more than 300 genes including the genes responsible for glucose and lipid metabolism.…”

Section: (Oh)mentioning

confidence: 99%

Role of Vitamin D in Etiopathogenesis and Metabolic Abnormalities Seen in Polycystic Ovarian Syndrome

Sukul

Bahinipati

Das

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Polycystic ovarian syndrome (PCOS) is a common cause of ovarian dysfunction in women in reproductive age group. It is now the leading cause of infertility among premenopausal women. PCOS women usually suffer from metabolic disturbances and insulin resistance (IR). Vitamin D has shown a significant role in glucose and insulin metabolism. Correlation studies have been done to examine the role of vitamin D in PCOS. However, still, Vitamin D status in PCOS remains varied. This study is an attempt to find out the association of Vitamin D with etiopathogenesis and metabolic risk factors seen in PCOS. Methods: Hundred subjects (50 PCOS and 50 age-matched normal control) were recruited for the study. Difference in biochemical parameters in PCOS women and normal group was measured, and association of Vitamin D with etiological and biochemical parameters in PCOS was seen. Results: There was a significant (p<0.001) increase in body mass index, serum insulin, fasting blood sugar (FBS), serum cholesterol, triglyceride, and low-density lipoprotein in PCOS. IR was observed in PCOS cases (homeostatic model assessment for β-cell function and IR = 6.40±1.96) compared to the control group (2.43±0.53). Serum 25(OH) Vitamin D3 was significantly decreased in PCOS (9.04±2.60 ng/ml) compared to control group (20.06±3.28 ng/ml). Negative correlation of serum Vitamin D was found with FBS, serum insulin, IR, HI, and serum testosterone. Vitamin D with metabolic parameters also showed a statistically significant negative correlation. Conclusion: Vitamin D deficiency may be a common comorbid manifestation of PCOS. Hence, Vitamin D supplementation may decrease the potential risk of morbidity and mortality associated with PCOS. However, further studies are needed which should include assessment of Vitamin D in women at various stages of PCOS to enhance the temporal order of Vitamin D deficiency in relation to PCOS.

show abstract

Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome

Cited by 30 publications

References 25 publications

Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Vitamin D, PCOS and androgens in men: a systematic review

Role of Vitamin D in Etiopathogenesis and Metabolic Abnormalities Seen in Polycystic Ovarian Syndrome

Contact Info

Product

Resources

About