Correlation of Zinc with Oxidative Stress Biomarkers

Abstract

Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual’s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20–59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson’s C = 0.639; p = 0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR = 2.80 (95%CI = 1.09–7.18) and AOR = 3.06 (95%CI = 0.96–9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.

Oxidative DNA damage level in relationship to zinc status in patients complaining hair fall, in Duhok city, Krg-Iraq: A case-control study

“…Moreover, the peak total oxidants in blood of hair fall-suffered objects could be correlated with lower levels of serum zinc that is remarkably influenced by oxidative stress. The same results were showed by Morales-Suárez-Varela et al (2015) who inspected the linkage between serum zinc and oxidative stress and measured minimal serum zinc levels respective with cellular senescence generated from oxidative exertion.…”

“…Murr et al (2012) indicated that the low concentration of serum zinc is usually associated with oxidative stress. Morales-Suárez-Varela et al (2015) detected the association between serum zinc and oxidative stress and revealed that the minimal serum zinc levels were strongly correlated with oxidative stress-generating cellular senescence. Mohammadi et al (2021) displayed that supplying adults with zinc created a reduction in oxidative stress and inflammatory markers.…”

CIMMYT Series on Carbohydrates, Wheat, Grains, and Health: Impact of Minerals, Phytochemicals, Specific Grain-Based Foods, and Dietary Patterns on Mild Cognitive Impairment, Alzheimer's Disease, and Parkinson's Disease

“…To add to the problem of inadequate intake, some elderly individuals have a reduced capacity to absorb or utilize zinc due to drugs or disease, which exacerbates the effects of low intakes (44). Low zinc levels in serum were correlated with oxidative stress and cellular aging (45).…”