Correlation study between serum neuro-specific enolase and gastric and colorectal cancers

Abstract

This study investigated the diagnostic value of preoperative serum neuro-specific enolase (NSE) in gastric cancer (GC) and colorectal cancer (CRC), and the diagnostic viability of combined serum NSE, carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, and CA242. Patients with GC and CRC, and a healthy control group (n = 666 and 266, respectively) were compared with regard to NSE, CEA, CA19-9, and CA242 serum levels. NSE was analyzed for associations with clinicopathological parameters. To estimate the diagnostic potential of NSE, a receiver operating characteristic curve was constructed and the area under the curve (AUCs) was calculated for different patient subgroups. The median serum NSE level of the tumor group (20.925 ng/mL) was significantly higher than that of the control (15.190 ng/mL). Serum NSE was associated with pathological tumor-node-metastasis staging, lymph node metastasis, distant metastasis, vascular invasion, and nerve infiltration. The area under the receiver operating characteristic curve (AUC) for NSE in GC and CRC (0.769) was higher than for the other 3 markers (0.571–0.680). The AUC of the combined markers was higher than for any of the markers individually (0.778–0.810). The AUC for NSE alone suggests it may be an independent tumor marker, and useful for diagnosis of GC and CRC. However, the AUC for combined NSE, CEA, CA19-9, and CA242 was higher and thus potentially more diagnostic value.

Cancer‐related thrombotic microangiopathy and disseminated intravascular coagulation in a patient with bone marrow carcinomatosis of unknown primary origin: A case report

“…On the other hand, decreased CDX2 expression is associated with poor differentiation and MMR deficiency in colorectal cancer 17 . In addition, it has been reported that elevated neuron‐specific enolase levels are seen in patients with advanced colorectal cancer 18 . Thus, although the patient had to be diagnosed with cancer of unknown primary origin, as lower gastrointestinal endoscopy was not performed, and the results of MMR deficiency‐related staining were inconclusive, it was assumed that colorectal cancer was likely to be the primary disease.…”

The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer

“…Our previous study showed sCEA is not independent factor while tCEA is for CRC ofⅠ~Ⅲ stage by multivariate analysis [8].Because the role of only preoperative serum for CRC has controversial issues, combined preoperative CEA and other tumor biomarkers are suggested [17,19,[34][35][36][37][38][39][40]. In this study of more recruited patients in 0&Ⅰ~Ⅳ, sCEA and tCEA are prognostic factors but not independent factors in CRC of Ⅲ~Ⅳ stages while combined CEA is an independent factor in advanced CRC by univariate and multivariate analysis.…”

Gastric cancer with brain metastasis: from molecular characteristics and treatment

“…During EMT, epithelial-like cancer cells transform to migratory and invasive mesenchymal-like cancer cells, acquiring a variety of characteristics such as self-renewal, self replication, differentiation and invasion of stroma ( 22 ). Neuroendocrine differentiation characterizes GC, and NSE, an enzyme specific to neuroendocrine cells, is a predictive and sensitive biomarker in GC ( 23 ). Studies have shown that down-regulating the expression of NSE gene can increase the expression of NM23 and E-cadherin, thereby inhibiting the proliferation and invasion of GC.…”